hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03937.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| UFL1 | E3 UFM1-protein ligase 1 (EC 2.3.2.-) (E3 UFM1-protein transferase 1) (Multiple alpha-helix protein located at ER) (Novel LZAP-binding protein) (Regulator of C53/LZAP and DDRGK1) | 5 | UniProt NCBI |
| UFM1 | Ubiquitin-fold modifier 1 | 5 | UniProt NCBI |
| CDK5RAP3 | CDK5 regulatory subunit-associated protein 3 (CDK5 activator-binding protein C53) (LXXLL/leucine-zipper-containing ARF-binding protein) (Protein HSF-27) | 5 | UniProt NCBI |
| DDRGK1 | DDRGK domain-containing protein 1 (Dashurin) (UFM1-binding and PCI domain-containing protein 1) | 5 | UniProt NCBI |
| UFC1 | Ubiquitin-fold modifier-conjugating enzyme 1 (Ufm1-conjugating enzyme 1) | 5 | UniProt NCBI |
| UBA5 | Ubiquitin-like modifier-activating enzyme 5 (Ubiquitin-activating enzyme 5) (ThiFP1) (UFM1-activating enzyme) (Ubiquitin-activating enzyme E1 domain-containing protein 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0071569 | 3.6979017959e-18 | 1.0 | DDRGK1 CDK5RAP3 UBA5 UFL1 UFM1 UFC1 | protein ufmylation |
| GO:1990592 | 5.40263452382e-14 | 0.833333333333 | UFM1 UBA5 UFC1 UFL1 DDRGK1 | protein K69-linked ufmylation |
| GO:1990564 | 5.40263452382e-14 | 0.833333333333 | UFM1 UBA5 UFC1 UFL1 DDRGK1 | protein polyufmylation |
| GO:0061709 | 3.34086198171e-10 | 0.833333333333 | UFM1 UBA5 UFC1 UFL1 DDRGK1 | reticulophagy |
| GO:0034976 | 8.14042722046e-08 | 1.0 | DDRGK1 CDK5RAP3 UBA5 UFL1 UFM1 UFC1 | response to endoplasmic reticulum stress |
| GO:0033146 | 3.48770721675e-06 | 0.666666666667 | UFM1 UBA5 UFL1 DDRGK1 | regulation of intracellular estrogen receptor signaling pathway |
| GO:0022411 | 2.21646445431e-05 | 1.0 | DDRGK1 CDK5RAP3 UBA5 UFL1 UFM1 UFC1 | cellular component disassembly |
| GO:1903008 | 2.57810974632e-05 | 0.833333333333 | UFM1 UBA5 UFC1 UFL1 DDRGK1 | organelle disassembly |
| GO:0030520 | 3.23392996598e-05 | 0.666666666667 | UFM1 UBA5 UFL1 DDRGK1 | intracellular estrogen receptor signaling pathway |
| GO:0033143 | 0.000114955637204 | 0.666666666667 | UFM1 UBA5 UFL1 DDRGK1 | regulation of intracellular steroid hormone receptor signaling pathway |
| GO:0032446 | 0.000206906049355 | 1.0 | DDRGK1 CDK5RAP3 UBA5 UFL1 UFM1 UFC1 | protein modification by small protein conjugation |
| GO:0070647 | 0.000374994553892 | 1.0 | DDRGK1 CDK5RAP3 UBA5 UFL1 UFM1 UFC1 | protein modification by small protein conjugation or removal |
| GO:0043687 | 0.000556668958492 | 1.0 | DDRGK1 CDK5RAP3 UBA5 UFL1 UFM1 UFC1 | post-translational protein modification |
| GO:0016236 | 0.000647964473215 | 0.833333333333 | UFM1 UBA5 UFC1 UFL1 DDRGK1 | macroautophagy |
| GO:0030518 | 0.00114118555867 | 0.666666666667 | UFM1 UBA5 UFL1 DDRGK1 | intracellular steroid hormone receptor signaling pathway |
| GO:0043401 | 0.00124402255411 | 0.666666666667 | UFM1 UBA5 UFL1 DDRGK1 | steroid hormone mediated signaling pathway |
| GO:0071383 | 0.0029910931425 | 0.666666666667 | UFM1 UBA5 UFL1 DDRGK1 | cellular response to steroid hormone stimulus |
| GO:0009755 | 0.00389790049139 | 0.666666666667 | UFM1 UBA5 UFL1 DDRGK1 | hormone-mediated signaling pathway |
| GO:0048545 | 0.0051482145534 | 0.666666666667 | UFM1 UBA5 UFL1 DDRGK1 | response to steroid hormone |
| GO:0071568 | 0.00702301080125 | 0.333333333333 | UFL1 UFC1 | UFM1 transferase activity |
| GO:0006914 | 0.00765815290464 | 0.833333333333 | UFM1 UBA5 UFC1 UFL1 DDRGK1 | autophagy |
| GO:0061919 | 0.00765815290464 | 0.833333333333 | UFM1 UBA5 UFC1 UFL1 DDRGK1 | process utilizing autophagic mechanism |
| GO:0033554 | 0.0233939744337 | 1.0 | DDRGK1 CDK5RAP3 UBA5 UFL1 UFM1 UFC1 | cellular response to stress |
| GO:1903895 | 0.042122686785 | 0.333333333333 | DDRGK1 UFL1 | negative regulation of IRE1-mediated unfolded protein response |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| UFL1 | CDK5RAP3 | 1.0 | 0.946 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 |
| DDRGK1 | CDK5RAP3 | 1.0 | 0.934 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| UFL1 | DDRGK1 | 1.0 | 0.94 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| UFM1 | UBA5 | 0.999 | 0.154 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| UFL1 | UFM1 | 0.998 | 0.214 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () |
| DDRGK1 | UFM1 | 0.994 | 0.128 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| DDRGK1 | UFC1 | 0.994 | 0.28 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| UFC1 | UBA5 | 0.993 | 0.142 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| UFL1 | UFC1 | 0.989 | 0.104 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () |
| UFM1 | CDK5RAP3 | 0.989 | 0.156 | hein_WMM bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| UFM1 | UFC1 | 0.97 | 0.168 | hein_WMM bioplex_WMM bioplex3_WMM fraction |
| CDK5RAP3 | UFC1 | 0.903 | 0.132 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| CDK5RAP3 | UBA5 | 0.081 | 0.036 | bioplex3_WMM WMM_only |
| UFL1 | UBA5 | 0.053 | 0.112 | bioplex3_WMM WMM_only |
| DDRGK1 | UBA5 | 0.007 | 0.166 | fraction |
Related Complexes