hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03951.1
Complex Portal: CPX-15906
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GNE | Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (UDP-GlcNAc-2-epimerase/ManAc kinase) [Includes: UDP-N-acetylglucosamine 2-epimerase (hydrolyzing) (EC 3.2.1.183) (UDP-GlcNAc-2-epimerase) (Uridine diphosphate-N-acetylglucosamine-2-epimerase); N-acetylmannosamine kinase (EC 2.7.1.60) (ManAc kinase)] | 5 | UniProt NCBI |
| GAS2L2 | GAS2-like protein 2 (GAS2-related protein on chromosome 17) (Growth arrest-specific protein 2-like 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0006536 | 0.0162434892157 | 1.0 | GNE GAS2L2 | Airway obstruction |
| REAC:R-HSA-4085011 | 0.0249718442457 | 0.5 | GNE | Defective GNE causes sialuria, NK and IBM2 |
| HP:0031603 | 0.0499436884913 | 0.5 | GAS2L2 | Impaired nasal mucociliary clearance |
| HP:0410156 | 0.0499436884913 | 0.5 | GNE | Increased level of N-acetylneuraminic acid in urine |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| GNE | GAS2L2 | 0.999 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes