hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_03955.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SH3RF3 | E3 ubiquitin-protein ligase SH3RF3 (EC 2.3.2.27) (Plenty of SH3s 2) (SH3 domain-containing RING finger protein 3) (SH3 multiple domains protein 4) | 5 | UniProt NCBI |
| ZNF395 | Zinc finger protein 395 (HD-regulating factor 2) (HDRF-2) (Huntington disease gene regulatory region-binding protein 2) (HD gene regulatory region-binding protein 2) (HDBP-2) (Papillomavirus regulatory factor 1) (PRF-1) (Papillomavirus-binding factor) | 5 | UniProt NCBI |
| ANKRD34A | Ankyrin repeat domain-containing protein 34A | 3 | UniProt NCBI |
| AKT1S1 | Proline-rich AKT1 substrate 1 (40 kDa proline-rich AKT substrate) | 5 | UniProt NCBI |
| SASH1 | SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) | 5 | UniProt NCBI |
| MAST3 | Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1) | 5 | UniProt NCBI |
| YWHAG | 14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed] | 5 | UniProt NCBI |
| FOXO3 | Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1) | 5 | UniProt NCBI |
| A0A1X9RU27 | None | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9614399 | 8.39516773096e-06 | 0.333333333333 | FOXO3 A0A1X9RU27 YWHAG | Regulation of localization of FOXO transcription factors |
| REAC:R-HSA-5674400 | 8.74167485853e-05 | 0.333333333333 | AKT1S1 A0A1X9RU27 FOXO3 | Constitutive Signaling by AKT1 E17K in Cancer |
| REAC:R-HSA-9614085 | 0.00128664481505 | 0.333333333333 | FOXO3 A0A1X9RU27 YWHAG | FOXO-mediated transcription |
| REAC:R-HSA-2219528 | 0.00263020123437 | 0.333333333333 | AKT1S1 A0A1X9RU27 FOXO3 | PI3K/AKT Signaling in Cancer |
| REAC:R-HSA-198693 | 0.00358554253109 | 0.222222222222 | FOXO3 A0A1X9RU27 | AKT phosphorylates targets in the nucleus |
| WP:WP4542 | 0.012380386891 | 0.222222222222 | FOXO3 A0A1X9RU27 | Leukocyte intrinsic Hippo pathway functions |
| KEGG:05131 | 0.0146549467572 | 0.333333333333 | AKT1S1 A0A1X9RU27 FOXO3 | Shigellosis |
| REAC:R-HSA-9615017 | 0.0237893486791 | 0.222222222222 | FOXO3 A0A1X9RU27 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes |
| KEGG:04213 | 0.0239862693019 | 0.222222222222 | AKT1S1 FOXO3 | Longevity regulating pathway - multiple species |
| CORUM:6730 | 0.0499842271994 | 0.111111111111 | YWHAG | 14-3-3 gamma-CXCR2 complex, unstimulated |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| YWHAG | FOXO3 | 0.991 | 0.444 | bioplex3_HEK293 bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only |
| YWHAG | ZNF395 | 0.973 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| YWHAG | SASH1 | 0.971 | 0.498 | bioplex3_HEK293 bioplex3_WMM boldt_WMM WMM_only |
| YWHAG | AKT1S1 | 0.971 | 0.188 | bioplex3_HEK293 bioplex3_WMM boldt boldt_WMM WMM_only |
| YWHAG | MAST3 | 0.963 | 0.369333333333 | bioplex3_HEK293 bioplex3_WMM boldt boldt_WMM WMM_only |
| YWHAG | SH3RF3 | 0.961 | 0.258 | bioplex3_HEK293 bioplex3_WMM boldt boldt_WMM WMM_only |
| YWHAG | ANKRD34A | 0.952 | bioplex3_HEK293 bioplex3_WMM boldt boldt_WMM WMM_only | |
| AKT1S1 | SASH1 | 0.539 | 0.046 | bioplex3_WMM WMM_only boldt_WMM |
| SASH1 | FOXO3 | 0.539 | 0.126 | bioplex3_WMM WMM_only boldt_WMM |
| AKT1S1 | ANKRD34A | 0.481 | bioplex3_WMM boldt boldt_WMM WMM_only | |
| ANKRD34A | SASH1 | 0.47 | bioplex3_WMM WMM_only boldt_WMM | |
| ANKRD34A | FOXO3 | 0.47 | bioplex3_WMM boldt boldt_WMM WMM_only | |
| SH3RF3 | ANKRD34A | 0.47 | bioplex3_WMM boldt boldt_WMM WMM_only | |
| SH3RF3 | SASH1 | 0.47 | 0.064 | bioplex3_WMM WMM_only boldt_WMM |
| SH3RF3 | FOXO3 | 0.447 | 0.098 | bioplex3_WMM boldt boldt_WMM WMM_only |
| AKT1S1 | SH3RF3 | 0.437 | 0.15 | bioplex3_WMM boldt boldt_WMM WMM_only |
| AKT1S1 | FOXO3 | 0.436 | 0.126 | bioplex3_WMM boldt boldt_WMM WMM_only |
| MAST3 | ANKRD34A | 0.284 | bioplex3_WMM boldt boldt_WMM WMM_only | |
| MAST3 | SH3RF3 | 0.284 | 0.086 | bioplex3_WMM boldt boldt_WMM WMM_only |
| ZNF395 | FOXO3 | 0.247 | bioplex3_WMM WMM_only | |
| AKT1S1 | ZNF395 | 0.247 | bioplex3_WMM WMM_only | |
| ZNF395 | SASH1 | 0.239 | bioplex3_WMM WMM_only | |
| MAST3 | ZNF395 | 0.21 | bioplex3_WMM WMM_only | |
| MAST3 | FOXO3 | 0.196 | 0.104 | bioplex3_WMM boldt boldt_WMM WMM_only |
| MAST3 | SASH1 | 0.196 | 0.072 | bioplex3_WMM WMM_only boldt_WMM |
| MAST3 | AKT1S1 | 0.196 | 0.062 | bioplex3_WMM boldt boldt_WMM WMM_only |
| SH3RF3 | ZNF395 | 0.079 | bioplex3_WMM WMM_only | |
| ZNF395 | ANKRD34A | 0.079 | bioplex3_WMM WMM_only |
Related Complexes