hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03960.1
Complex Portal: CPX-13333
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ZNF207 | BUB3-interacting and GLEBS motif-containing protein ZNF207 (BuGZ) (hBuGZ) (Zinc finger protein 207) | 5 | UniProt NCBI |
| BUB1 | Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) | 5 | UniProt NCBI |
| BUB3 | Mitotic checkpoint protein BUB3 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1851 | 3.41752350426e-06 | 0.666666666667 | BUB1 BUB3 | BUB1-BUB3 complex |
| WP:WP4240 | 0.000103023242897 | 0.666666666667 | BUB1 BUB3 | Regulation of sister chromatid separation at the metaphase anaphase transition |
| HP:0100650 | 0.000569225481094 | 0.666666666667 | BUB1 BUB3 | Vaginal neoplasm |
| GO:0071173 | 0.00102463963787 | 1.0 | ZNF207 BUB1 BUB3 | spindle assembly checkpoint signaling |
| GO:0007094 | 0.00102463963787 | 1.0 | ZNF207 BUB1 BUB3 | mitotic spindle assembly checkpoint signaling |
| GO:0071174 | 0.00102463963787 | 1.0 | ZNF207 BUB1 BUB3 | mitotic spindle checkpoint signaling |
| GO:2000816 | 0.00110345807156 | 1.0 | ZNF207 BUB1 BUB3 | negative regulation of mitotic sister chromatid separation |
| GO:0031577 | 0.00110345807156 | 1.0 | ZNF207 BUB1 BUB3 | spindle checkpoint signaling |
| GO:0033046 | 0.00110345807156 | 1.0 | ZNF207 BUB1 BUB3 | negative regulation of sister chromatid segregation |
| GO:0033048 | 0.00110345807156 | 1.0 | ZNF207 BUB1 BUB3 | negative regulation of mitotic sister chromatid segregation |
| GO:0045841 | 0.00110345807156 | 1.0 | ZNF207 BUB1 BUB3 | negative regulation of mitotic metaphase/anaphase transition |
| GO:1902100 | 0.00127301382402 | 1.0 | ZNF207 BUB1 BUB3 | negative regulation of metaphase/anaphase transition of cell cycle |
| GO:1905819 | 0.00127301382402 | 1.0 | ZNF207 BUB1 BUB3 | negative regulation of chromosome separation |
| GO:0051985 | 0.00127301382402 | 1.0 | ZNF207 BUB1 BUB3 | negative regulation of chromosome segregation |
| GO:0033047 | 0.00166249223046 | 1.0 | ZNF207 BUB1 BUB3 | regulation of mitotic sister chromatid segregation |
| GO:0045839 | 0.00177091563679 | 1.0 | ZNF207 BUB1 BUB3 | negative regulation of mitotic nuclear division |
| GO:0051784 | 0.00212425290779 | 1.0 | ZNF207 BUB1 BUB3 | negative regulation of nuclear division |
| GO:0010965 | 0.00212425290779 | 1.0 | ZNF207 BUB1 BUB3 | regulation of mitotic sister chromatid separation |
| GO:0051306 | 0.00238416149886 | 1.0 | ZNF207 BUB1 BUB3 | mitotic sister chromatid separation |
| HP:0001682 | 0.00265505202111 | 0.666666666667 | BUB1 BUB3 | Subvalvular aortic stenosis |
| HP:0002859 | 0.00319841341764 | 0.666666666667 | BUB1 BUB3 | Rhabdomyosarcoma |
| HP:0011103 | 0.00348901893966 | 0.666666666667 | BUB1 BUB3 | Abnormal left ventricular outflow tract morphology |
| GO:1905818 | 0.00439845307966 | 1.0 | ZNF207 BUB1 BUB3 | regulation of chromosome separation |
| HP:0009728 | 0.00443651401809 | 0.666666666667 | BUB1 BUB3 | Neoplasm of striated muscle |
| HP:0012126 | 0.00549749049527 | 0.666666666667 | BUB1 BUB3 | Stomach cancer |
| GO:0051304 | 0.0057325992498 | 1.0 | ZNF207 BUB1 BUB3 | chromosome separation |
| HP:0002667 | 0.00667190161012 | 0.666666666667 | BUB1 BUB3 | Nephroblastoma |
| HP:0011794 | 0.00708857159683 | 0.666666666667 | BUB1 BUB3 | Embryonal renal neoplasm |
| WP:WP179 | 0.00751610583681 | 0.666666666667 | BUB1 BUB3 | Cell cycle |
| HP:0006721 | 0.0075178385046 | 0.666666666667 | BUB1 BUB3 | Acute lymphoblastic leukemia |
| GO:0030071 | 0.00851239083773 | 1.0 | ZNF207 BUB1 BUB3 | regulation of mitotic metaphase/anaphase transition |
| KEGG:04110 | 0.00858640718729 | 0.666666666667 | BUB1 BUB3 | Cell cycle |
| HP:0002247 | 0.00888120343534 | 0.666666666667 | BUB1 BUB3 | Duodenal atresia |
| GO:1902099 | 0.00915870199393 | 1.0 | ZNF207 BUB1 BUB3 | regulation of metaphase/anaphase transition of cell cycle |
| HP:0002101 | 0.00936084070842 | 0.666666666667 | BUB1 BUB3 | Abnormal lung lobation |
| GO:0007091 | 0.00983692500376 | 1.0 | ZNF207 BUB1 BUB3 | metaphase/anaphase transition of mitotic cell cycle |
| HP:0003003 | 0.00985306624309 | 0.666666666667 | BUB1 BUB3 | Colon cancer |
| GO:2001251 | 0.0101882437539 | 1.0 | ZNF207 BUB1 BUB3 | negative regulation of chromosome organization |
| GO:0044784 | 0.0105478288276 | 1.0 | ZNF207 BUB1 BUB3 | metaphase/anaphase transition of cell cycle |
| GO:0033045 | 0.0133044554856 | 1.0 | ZNF207 BUB1 BUB3 | regulation of sister chromatid segregation |
| GO:0007088 | 0.0133044554856 | 1.0 | ZNF207 BUB1 BUB3 | regulation of mitotic nuclear division |
| HP:0010880 | 0.0160978770685 | 0.666666666667 | BUB1 BUB3 | Increased nuchal translucency |
| GO:0051783 | 0.0165038110528 | 1.0 | ZNF207 BUB1 BUB3 | regulation of nuclear division |
| HP:0007565 | 0.0201452261528 | 0.666666666667 | BUB1 BUB3 | Multiple cafe-au-lait spots |
| HP:0200008 | 0.0208637442425 | 0.666666666667 | BUB1 BUB3 | Intestinal polyposis |
| HP:0011100 | 0.0215948176879 | 0.666666666667 | BUB1 BUB3 | Intestinal atresia |
| HP:0005266 | 0.023094623718 | 0.666666666667 | BUB1 BUB3 | Intestinal polyp |
| HP:0002898 | 0.024644630388 | 0.666666666667 | BUB1 BUB3 | Embryonal neoplasm |
| GO:0051983 | 0.0263194935275 | 1.0 | ZNF207 BUB1 BUB3 | regulation of chromosome segregation |
| HP:0033020 | 0.0270637362845 | 0.666666666667 | BUB1 BUB3 | Female reproductive system neoplasm |
| REAC:R-HSA-141424 | 0.0284248695791 | 0.666666666667 | BUB1 BUB3 | Amplification of signal from the kinetochores |
| REAC:R-HSA-141444 | 0.0284248695791 | 0.666666666667 | BUB1 BUB3 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| HP:0001360 | 0.0287391839378 | 0.666666666667 | BUB1 BUB3 | Holoprosencephaly |
| GO:0007093 | 0.0298091316188 | 1.0 | ZNF207 BUB1 BUB3 | mitotic cell cycle checkpoint signaling |
| HP:0003560 | 0.0322405218297 | 0.666666666667 | BUB1 BUB3 | Muscular dystrophy |
| HP:0006753 | 0.0349981079563 | 0.666666666667 | BUB1 BUB3 | Neoplasm of the stomach |
| HP:0002797 | 0.037868427304 | 0.666666666667 | BUB1 BUB3 | Osteolysis |
| HP:0002589 | 0.0388502441646 | 0.666666666667 | BUB1 BUB3 | Gastrointestinal atresia |
| HP:0002246 | 0.0388502441646 | 0.666666666667 | BUB1 BUB3 | Abnormal duodenum morphology |
| REAC:R-HSA-69618 | 0.0392065258044 | 0.666666666667 | BUB1 BUB3 | Mitotic Spindle Checkpoint |
| GO:0000776 | 0.0402954436201 | 1.0 | ZNF207 BUB1 BUB3 | kinetochore |
| HP:0100273 | 0.0408514331117 | 0.666666666667 | BUB1 BUB3 | Neoplasm of the colon |
| HP:0000003 | 0.0429026841472 | 0.666666666667 | BUB1 BUB3 | Multicystic kidney dysplasia |
| REAC:R-HSA-9648025 | 0.0429286997388 | 0.666666666667 | BUB1 BUB3 | EML4 and NUDC in mitotic spindle formation |
| GO:0000779 | 0.0439566559847 | 1.0 | ZNF207 BUB1 BUB3 | condensed chromosome, centromeric region |
| HP:0001659 | 0.045003983416 | 0.666666666667 | BUB1 BUB3 | Aortic regurgitation |
| GO:1901991 | 0.0468435252984 | 1.0 | ZNF207 BUB1 BUB3 | negative regulation of mitotic cell cycle phase transition |
| REAC:R-HSA-2500257 | 0.049233254294 | 0.666666666667 | BUB1 BUB3 | Resolution of Sister Chromatid Cohesion |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| BUB1 | BUB3 | 0.999 | 0.34 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 |
| ZNF207 | BUB3 | 0.994 | 0.925333333333 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| ZNF207 | BUB1 | 0.981 | 0.16 |
mutually_exclusive (O43684)
|
bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| ZNF207 | huMAP3_03960.1 huMAP3_12747.1 |
| BUB1 | huMAP3_03960.1 huMAP3_11940.1 |
| BUB3 | huMAP3_03960.1 huMAP3_12747.1 |