hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03963.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ATP5F1B | ATP synthase subunit beta, mitochondrial (EC 7.1.2.2) (ATP synthase F1 subunit beta) | 5 | UniProt NCBI |
| ATP5F1E | ATP synthase subunit epsilon, mitochondrial (ATPase subunit epsilon) (ATP synthase F1 subunit epsilon) | 5 | UniProt NCBI |
| ATP5MC3 | ATP synthase F(0) complex subunit C3, mitochondrial (ATP synthase lipid-binding protein) (ATP synthase membrane subunit c locus 3) (ATP synthase proteolipid P3) (ATP synthase proton-transporting mitochondrial F(0) complex subunit C3) (ATPase protein 9) (ATPase subunit c) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-163210 | 3.80747347177e-07 | 1.0 | ATP5F1E ATP5F1B ATP5MC3 | Formation of ATP by chemiosmotic coupling |
| REAC:R-HSA-8949613 | 1.89440469306e-06 | 1.0 | ATP5F1E ATP5F1B ATP5MC3 | Cristae formation |
| WP:WP623 | 2.51997291561e-06 | 1.0 | ATP5F1E ATP5F1B ATP5MC3 | Oxidative phosphorylation |
| WP:WP4932 | 1.10755092492e-05 | 1.0 | ATP5F1E ATP5F1B ATP5MC3 | 7q11 23 copy number variation syndrome |
| WP:WP111 | 1.17898981996e-05 | 1.0 | ATP5F1E ATP5F1B ATP5MC3 | Electron transport chain OXPHOS system in mitochondria |
| KEGG:00190 | 1.54230874605e-05 | 1.0 | ATP5F1E ATP5F1B ATP5MC3 | Oxidative phosphorylation |
| REAC:R-HSA-1592230 | 4.77520631251e-05 | 1.0 | ATP5F1E ATP5F1B ATP5MC3 | Mitochondrial biogenesis |
| KEGG:05415 | 5.16258651055e-05 | 1.0 | ATP5F1E ATP5F1B ATP5MC3 | Diabetic cardiomyopathy |
| KEGG:05208 | 7.07004693439e-05 | 1.0 | ATP5F1E ATP5F1B ATP5MC3 | Chemical carcinogenesis - reactive oxygen species |
| KEGG:04714 | 7.39136996301e-05 | 1.0 | ATP5F1E ATP5F1B ATP5MC3 | Thermogenesis |
| KEGG:05012 | 0.00011589966492 | 1.0 | ATP5F1E ATP5F1B ATP5MC3 | Parkinson disease |
| KEGG:05020 | 0.000126475690353 | 1.0 | ATP5F1E ATP5F1B ATP5MC3 | Prion disease |
| GO:0045259 | 0.000127839654632 | 1.0 | ATP5F1E ATP5F1B ATP5MC3 | proton-transporting ATP synthase complex |
| GO:0005753 | 0.000127839654632 | 1.0 | ATP5F1E ATP5F1B ATP5MC3 | mitochondrial proton-transporting ATP synthase complex |
| REAC:R-HSA-163200 | 0.000134372084608 | 1.0 | ATP5F1E ATP5F1B ATP5MC3 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| KEGG:05016 | 0.000171368189864 | 1.0 | ATP5F1E ATP5F1B ATP5MC3 | Huntington disease |
| CORUM:563 | 0.000225453649047 | 0.666666666667 | ATP5F1E ATP5F1B | F1F0-ATP synthase, mitochondrial |
| KEGG:05014 | 0.00029339200738 | 1.0 | ATP5F1E ATP5F1B ATP5MC3 | Amyotrophic lateral sclerosis |
| KEGG:05010 | 0.000339187774081 | 1.0 | ATP5F1E ATP5F1B ATP5MC3 | Alzheimer disease |
| REAC:R-HSA-1428517 | 0.000368729542429 | 1.0 | ATP5F1E ATP5F1B ATP5MC3 | The citric acid (TCA) cycle and respiratory electron transport |
| KEGG:05022 | 0.000613327564103 | 1.0 | ATP5F1E ATP5F1B ATP5MC3 | Pathways of neurodegeneration - multiple diseases |
| GO:0016469 | 0.00127301382402 | 1.0 | ATP5F1E ATP5F1B ATP5MC3 | proton-transporting two-sector ATPase complex |
| REAC:R-HSA-1852241 | 0.00159971044576 | 1.0 | ATP5F1E ATP5F1B ATP5MC3 | Organelle biogenesis and maintenance |
| GO:0015986 | 0.00526161104852 | 1.0 | ATP5F1E ATP5F1B ATP5MC3 | proton motive force-driven ATP synthesis |
| GO:0006754 | 0.00851239083773 | 1.0 | ATP5F1E ATP5F1B ATP5MC3 | ATP biosynthetic process |
| GO:0009145 | 0.00915870199393 | 1.0 | ATP5F1E ATP5F1B ATP5MC3 | purine nucleoside triphosphate biosynthetic process |
| GO:0009206 | 0.00915870199393 | 1.0 | ATP5F1E ATP5F1B ATP5MC3 | purine ribonucleoside triphosphate biosynthetic process |
| GO:0009201 | 0.0109157763448 | 1.0 | ATP5F1E ATP5F1B ATP5MC3 | ribonucleoside triphosphate biosynthetic process |
| GO:0009142 | 0.0120707547584 | 1.0 | ATP5F1E ATP5F1B ATP5MC3 | nucleoside triphosphate biosynthetic process |
| GO:0000275 | 0.0140440992017 | 0.666666666667 | ATP5F1E ATP5F1B | mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) |
| KEGG:01100 | 0.0189521995452 | 1.0 | ATP5F1E ATP5F1B ATP5MC3 | Metabolic pathways |
| GO:0045261 | 0.0210651876021 | 0.666666666667 | ATP5F1E ATP5F1B | proton-transporting ATP synthase complex, catalytic core F(1) |
| HP:0001987 | 0.0331471884053 | 0.666666666667 | ATP5F1E ATP5F1B | Hyperammonemia |
| GO:1904949 | 0.042099520671 | 1.0 | ATP5F1E ATP5F1B ATP5MC3 | ATPase complex |
| GO:0098800 | 0.0498541011049 | 1.0 | ATP5F1E ATP5F1B ATP5MC3 | inner mitochondrial membrane protein complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ATP5F1E | ATP5F1B | 0.994 | 0.72 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM |
| ATP5F1B | ATP5MC3 | 0.978 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ATP5F1E | ATP5MC3 | 0.958 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes