hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_03971.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DUS2 | tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (EC 1.3.1.91) (Dihydrouridine synthase 2) (Up-regulated in lung cancer protein 8) (URLC8) (tRNA-dihydrouridine synthase 2-like) (hDUS2) | 5 | UniProt NCBI |
| KAT8 | Histone acetyltransferase KAT8 (EC 2.3.1.48) (Lysine acetyltransferase 8) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1) (MYST-1) (hMOF) | 5 | UniProt NCBI |
| MCRS1 | Microspherule protein 1 (58 kDa microspherule protein) (Cell cycle-regulated factor p78) (INO80 complex subunit J) (MCRS2) | 5 | UniProt NCBI |
| PHF20 | PHD finger protein 20 (Glioma-expressed antigen 2) (Hepatocellular carcinoma-associated antigen 58) (Novel zinc finger protein) (Transcription factor TZP) | 5 | UniProt NCBI |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 (MLL1/MLL complex subunit KANSL1) (MSL1 homolog 1) (hMSL1v1) (NSL complex protein NSL1) (Non-specific lethal 1 homolog) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7221 | 4.831609132e-11 | 0.8 | PHF20 KANSL1 KAT8 MCRS1 | NSL complex |
| CORUM:5386 | 5.72740505133e-09 | 0.8 | PHF20 KANSL1 KAT8 MCRS1 | MLL1-WDR5 complex |
| REAC:R-HSA-9772755 | 3.89605743335e-08 | 0.8 | PHF20 KANSL1 KAT8 MCRS1 | Formation of WDR5-containing histone-modifying complexes |
| GO:0044545 | 4.33992010508e-08 | 0.8 | PHF20 KANSL1 KAT8 MCRS1 | NSL complex |
| GO:0071339 | 4.13351489328e-06 | 0.8 | PHF20 KANSL1 KAT8 MCRS1 | MLL1 complex |
| REAC:R-HSA-3214847 | 4.67050314665e-06 | 0.8 | PHF20 KANSL1 KAT8 MCRS1 | HATs acetylate histones |
| GO:0044665 | 4.72375798258e-06 | 0.8 | PHF20 KANSL1 KAT8 MCRS1 | MLL1/2 complex |
| REAC:R-HSA-212165 | 1.45553942328e-05 | 0.8 | PHF20 KANSL1 KAT8 MCRS1 | Epigenetic regulation of gene expression |
| GO:1902562 | 1.46952249556e-05 | 0.8 | PHF20 KANSL1 KAT8 MCRS1 | H4 histone acetyltransferase complex |
| REAC:R-HSA-3247509 | 6.69531345818e-05 | 0.8 | PHF20 KANSL1 KAT8 MCRS1 | Chromatin modifying enzymes |
| REAC:R-HSA-4839726 | 6.69531345818e-05 | 0.8 | PHF20 KANSL1 KAT8 MCRS1 | Chromatin organization |
| CORUM:610 | 8.18785830799e-05 | 0.4 | KAT8 KANSL1 | MSL complex |
| GO:0035097 | 8.33174548553e-05 | 0.8 | PHF20 KANSL1 KAT8 MCRS1 | histone methyltransferase complex |
| GO:0000123 | 0.000305379790485 | 0.8 | PHF20 KANSL1 KAT8 MCRS1 | histone acetyltransferase complex |
| GO:0034708 | 0.000349949920328 | 0.8 | PHF20 KANSL1 KAT8 MCRS1 | methyltransferase complex |
| GO:0031248 | 0.000472796969853 | 0.8 | PHF20 KANSL1 KAT8 MCRS1 | protein acetyltransferase complex |
| GO:1902493 | 0.000472796969853 | 0.8 | PHF20 KANSL1 KAT8 MCRS1 | acetyltransferase complex |
| REAC:R-HSA-74160 | 0.046583533294 | 0.8 | PHF20 KANSL1 KAT8 MCRS1 | Gene expression (Transcription) |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PHF20 | KANSL1 | 0.999 | 0.41 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| MCRS1 | KANSL1 | 0.997 | 0.482 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| KANSL1 | DUS2 | 0.995 | 0.046 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| KANSL1 | KAT8 | 0.994 | 0.192 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
| MCRS1 | PHF20 | 0.992 | 0.374 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| MCRS1 | KAT8 | 0.99 | 0.584 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
| PHF20 | KAT8 | 0.99 | 0.266 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| PHF20 | DUS2 | 0.572 | 0.07 | bioplex_WMM bioplex3_WMM WMM_only |
| MCRS1 | DUS2 | 0.143 | 0.076 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes