hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04004.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CYTH1 | Cytohesin-1 (PH, SEC7 and coiled-coil domain-containing protein 1) (SEC7 homolog B2-1) | 5 | UniProt NCBI |
| IPCEF1 | Interactor protein for cytohesin exchange factors 1 (Phosphoinositide-binding protein PIP3-E) | 5 | UniProt NCBI |
| CYTIP | Cytohesin-interacting protein (Cytohesin binder and regulator) (CYBR) (Cytohesin-associated scaffolding protein) (CASP) (Cytohesin-binding protein HE) (Cbp HE) (Pleckstrin homology Sec7 and coiled-coil domains-binding protein) | 5 | UniProt NCBI |
| CYTH2 | Cytohesin-2 (ARF exchange factor) (ARF nucleotide-binding site opener) (Protein ARNO) (PH, SEC7 and coiled-coil domain-containing protein 2) | 5 | UniProt NCBI |
| CYTH3 | Cytohesin-3 (ARF nucleotide-binding site opener 3) (Protein ARNO3) (General receptor of phosphoinositides 1) (Grp1) (PH, SEC7 and coiled-coil domain-containing protein 3) | 5 | UniProt NCBI |
| FRMD4A | FERM domain-containing protein 4A | 5 | UniProt NCBI |
| CNKSR1 | Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR 1) (CNK homolog protein 1) (CNK1) (hCNK1) (Connector enhancer of KSR-like) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-6811438 | 0.000171246735353 | 0.428571428571 | CYTH1 CYTH3 CYTH2 | Intra-Golgi traffic |
| KEGG:04072 | 0.000869612930158 | 0.428571428571 | CYTH1 CYTH3 CYTH2 | Phospholipase D signaling pathway |
| WP:WP5224 | 0.00111875977132 | 0.428571428571 | CYTH1 CYTH3 CYTH2 | 2q37 copy number variation syndrome |
| KEGG:05130 | 0.0024968157629 | 0.428571428571 | CYTH1 CYTH3 CYTH2 | Pathogenic Escherichia coli infection |
| KEGG:05132 | 0.00620117831779 | 0.428571428571 | CYTH1 CYTH3 CYTH2 | Salmonella infection |
| KEGG:05131 | 0.00645082416518 | 0.428571428571 | CYTH1 CYTH3 CYTH2 | Shigellosis |
| KEGG:04144 | 0.00679381427833 | 0.428571428571 | CYTH1 CYTH3 CYTH2 | Endocytosis |
| REAC:R-HSA-6811442 | 0.0147908747224 | 0.428571428571 | CYTH1 CYTH3 CYTH2 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| CORUM:1063 | 0.0499958217778 | 0.142857142857 | CYTH3 | GRASP-GRP1 complex |
| CORUM:5925 | 0.0499958217778 | 0.142857142857 | CNKSR1 | BRAF-CNK1 complex, not RAS stimulated |
| CORUM:5926 | 0.0499958217778 | 0.142857142857 | CNKSR1 | CNK1 homodimer complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CYTH1 | CNKSR1 | 1.0 | bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 | |
| CYTH2 | CYTIP | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CYTH1 | IPCEF1 | 1.0 | 0.108 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| CYTH2 | IPCEF1 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CYTIP | CYTH3 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CYTH1 | CYTIP | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CYTH1 | CYTH3 | 0.999 | 0.11 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| CYTH3 | IPCEF1 | 0.999 | 0.162 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| CYTH1 | CYTH2 | 0.998 | 0.084 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| CYTH2 | CYTH3 | 0.995 | 0.112 | bioplex_WMM bioplex3_WMM WMM_only |
| CYTH1 | FRMD4A | 0.993 | 0.19 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| CYTH2 | CNKSR1 | 0.99 | bioplex3_HEK293 bioplex () bioplex3_WMM | |
| CYTH3 | CNKSR1 | 0.986 | bioplex3_HEK293 bioplex () bioplex3_WMM | |
| FRMD4A | CNKSR1 | 0.902 | bioplex3_WMM WMM_only | |
| CYTH3 | FRMD4A | 0.412 | 0.122 | bioplex3_WMM WMM_only bioplex_WMM |
| CYTH2 | FRMD4A | 0.076 | 0.188 | bioplex3_WMM WMM_only |
Related Complexes