hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04009.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| FUZ | Protein fuzzy homolog | 5 | UniProt NCBI |
| WDPCP | WD repeat-containing and planar cell polarity effector protein fritz homolog (hFRTZ) (Bardet-Biedl syndrome 15 protein) (WD repeat-containing and planar cell polarity effector protein) | 5 | UniProt NCBI |
| CPLANE2 | Ciliogenesis and planar polarity effector 2 (REM2- and Rab-like small GTPase 1) | 5 | UniProt NCBI |
| INTU | Protein inturned (Inturned planar cell polarity effector homolog) (PDZ domain-containing protein 6) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4536 | 5.29024993618e-05 | 0.75 | WDPCP FUZ CPLANE2 | Genes related to primary cilium development based on CRISPR |
| GO:0001736 | 6.34131776058e-05 | 0.75 | WDPCP FUZ INTU | establishment of planar polarity |
| GO:0007164 | 6.34131776058e-05 | 0.75 | WDPCP FUZ INTU | establishment of tissue polarity |
| GO:0001738 | 0.00125794076491 | 0.75 | WDPCP FUZ INTU | morphogenesis of a polarized epithelium |
| HP:0001674 | 0.00220521848756 | 0.5 | WDPCP INTU | Complete atrioventricular canal defect |
| GO:0042073 | 0.00440499676786 | 0.75 | WDPCP FUZ INTU | intraciliary transport |
| HP:0011802 | 0.0057098705025 | 0.5 | WDPCP INTU | Hamartoma of tongue |
| GO:0060271 | 0.00604511321054 | 1.0 | WDPCP INTU FUZ CPLANE2 | cilium assembly |
| GO:0021915 | 0.00622026610693 | 0.75 | WDPCP FUZ INTU | neural tube development |
| WP:WP5234 | 0.00722934152515 | 0.5 | WDPCP FUZ | Bardet Biedl syndrome |
| GO:0044782 | 0.00802497752911 | 1.0 | WDPCP INTU FUZ CPLANE2 | cilium organization |
| GO:1902017 | 0.0112187083505 | 0.75 | WDPCP FUZ INTU | regulation of cilium assembly |
| HP:0100648 | 0.0234332085093 | 0.5 | WDPCP INTU | Neoplasm of the tongue |
| GO:0120031 | 0.0282069641472 | 1.0 | WDPCP INTU FUZ CPLANE2 | plasma membrane bounded cell projection assembly |
| WP:WP4803 | 0.030443565418 | 0.5 | WDPCP INTU | Ciliopathies |
| GO:0030031 | 0.0311314419202 | 1.0 | WDPCP INTU FUZ CPLANE2 | cell projection assembly |
| HP:0006695 | 0.036003514982 | 0.5 | WDPCP INTU | Atrioventricular canal defect |
| GO:0005929 | 0.0390756675372 | 1.0 | WDPCP INTU FUZ CPLANE2 | cilium |
| GO:0043587 | 0.042122686785 | 0.5 | WDPCP INTU | tongue morphogenesis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| FUZ | CPLANE2 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM | |
| FUZ | INTU | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM | |
| FUZ | WDPCP | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| INTU | CPLANE2 | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt_WMM | |
| WDPCP | CPLANE2 | 0.572 | bioplex_WMM bioplex3_WMM WMM_only | |
| WDPCP | INTU | 0.572 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes