hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04020.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SMG8 | Nonsense-mediated mRNA decay factor SMG8 (Amplified in breast cancer gene 2 protein) (Protein smg-8 homolog) | 5 | UniProt NCBI |
| SMG1 | Serine/threonine-protein kinase SMG1 (SMG-1) (hSMG-1) (EC 2.7.11.1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (Nonsense mediated mRNA decay-associated PI3K-related kinase SMG1) | 5 | UniProt NCBI |
| SMG9 | Nonsense-mediated mRNA decay factor SMG9 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-975957 | 0.000112201017269 | 1.0 | SMG8 SMG1 SMG9 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
| REAC:R-HSA-927802 | 0.000112201017269 | 1.0 | SMG8 SMG1 SMG9 | Nonsense-Mediated Decay (NMD) |
| GO:0000184 | 0.000524430944113 | 1.0 | SMG8 SMG1 SMG9 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| GO:0000956 | 0.0219076797621 | 1.0 | SMG8 SMG1 SMG9 | nuclear-transcribed mRNA catabolic process |
| REAC:R-HSA-8953854 | 0.0247774527734 | 1.0 | SMG8 SMG1 SMG9 | Metabolism of RNA |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SMG1 | SMG9 | 0.995 | 0.092 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () |
| SMG8 | SMG9 | 0.969 | 0.188 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () |
| SMG8 | SMG1 | 0.966 | 0.14 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes