hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04023.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| POLDIP3 | Polymerase delta-interacting protein 3 (46 kDa DNA polymerase delta interaction protein) (p46) (S6K1 Aly/REF-like target) (SKAR) | 5 | UniProt NCBI |
| THOC6 | THO complex subunit 6 homolog (Functional spliceosome-associated protein 35) (fSAP35) (WD repeat-containing protein 58) | 5 | UniProt NCBI |
| RSPO1 | R-spondin-1 (Roof plate-specific spondin-1) (hRspo1) | 5 | UniProt NCBI |
| ALYREF | THO complex subunit 4 (Tho4) (Ally of AML-1 and LEF-1) (Aly/REF export factor) (Transcriptional coactivator Aly/REF) (bZIP-enhancing factor BEF) | 5 | UniProt NCBI |
| CHTOP | Chromatin target of PRMT1 protein (Friend of PRMT1 protein) (Small arginine- and glycine-rich protein) (SRAG) | 5 | UniProt NCBI |
| ALKBH5 | RNA demethylase ALKBH5 (EC 1.14.11.53) (Alkylated DNA repair protein alkB homolog 5) (Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5) | 5 | UniProt NCBI |
| FXR1 | RNA-binding protein FXR1 (FMR1 autosomal homolog 1) (hFXR1p) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-72187 | 0.000183939263613 | 0.5 | THOC6 POLDIP3 CHTOP | mRNA 3'-end processing |
| REAC:R-HSA-73856 | 0.00027807877525 | 0.5 | THOC6 POLDIP3 CHTOP | RNA Polymerase II Transcription Termination |
| GO:0006406 | 0.000282532632952 | 0.666666666667 | ALKBH5 THOC6 POLDIP3 CHTOP | mRNA export from nucleus |
| REAC:R-HSA-159236 | 0.00038290615081 | 0.5 | THOC6 POLDIP3 CHTOP | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| GO:0051028 | 0.000403034704454 | 0.666666666667 | ALKBH5 THOC6 POLDIP3 CHTOP | mRNA transport |
| REAC:R-HSA-72202 | 0.000552388845795 | 0.5 | THOC6 POLDIP3 CHTOP | Transport of Mature Transcript to Cytoplasm |
| GO:0006405 | 0.000792088897246 | 0.666666666667 | ALKBH5 THOC6 POLDIP3 CHTOP | RNA export from nucleus |
| GO:0050657 | 0.0020139313777 | 0.666666666667 | ALKBH5 THOC6 POLDIP3 CHTOP | nucleic acid transport |
| GO:0050658 | 0.0020139313777 | 0.666666666667 | ALKBH5 THOC6 POLDIP3 CHTOP | RNA transport |
| GO:0051236 | 0.00225224503687 | 0.666666666667 | ALKBH5 THOC6 POLDIP3 CHTOP | establishment of RNA localization |
| GO:0006403 | 0.00596067597779 | 0.666666666667 | ALKBH5 THOC6 POLDIP3 CHTOP | RNA localization |
| GO:0051168 | 0.0063111355837 | 0.666666666667 | ALKBH5 THOC6 POLDIP3 CHTOP | nuclear export |
| GO:0015931 | 0.00766019783716 | 0.666666666667 | ALKBH5 THOC6 POLDIP3 CHTOP | nucleobase-containing compound transport |
| REAC:R-HSA-72203 | 0.0229811698012 | 0.5 | THOC6 POLDIP3 CHTOP | Processing of Capped Intron-Containing Pre-mRNA |
| HPA:0340463 | 0.026375700343 | 0.5 | CHTOP POLDIP3 ALKBH5 | ovary; ovarian stroma cells[High] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ALYREF | CHTOP | 0.999 | 0.572 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction treiber_WMM |
| RSPO1 | CHTOP | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| POLDIP3 | ALKBH5 | 0.994 | 0.164 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| POLDIP3 | THOC6 | 0.992 | 0.304 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| CHTOP | FXR1 | 0.991 | 0.178 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| CHTOP | ALKBH5 | 0.975 | 0.048 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| POLDIP3 | ALYREF | 0.974 | 0.484 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction treiber_WMM |
| THOC6 | CHTOP | 0.972 | 0.146 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM fraction |
| THOC6 | FXR1 | 0.968 | 0.086 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| ALYREF | ALKBH5 | 0.966 | 0.158 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| POLDIP3 | CHTOP | 0.96 | 0.322 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction |
| THOC6 | ALYREF | 0.949 | 0.284 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction |
| THOC6 | ALKBH5 | 0.663 | 0.152 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| POLDIP3 | FXR1 | 0.616 | 0.242 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM treiber_WMM WMM_only |
| FXR1 | ALKBH5 | 0.611 | 0.062 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| ALYREF | FXR1 | 0.17 | 0.19 | hein_WMM youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction |
| THOC6 | RSPO1 | 0.038 | bioplex3_HEK293 bioplex () bioplex3_WMM | |
| RSPO1 | FXR1 | 0.012 | bioplex3_HEK293 bioplex () bioplex3_HCT116 | |
| RSPO1 | ALYREF | 0.004 | bioplex3_HEK293 bioplex () bioplex3_HCT116 |
Related Complexes