hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04026.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DNM2 | Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II) | 5 | UniProt NCBI |
| DNM1 | Dynamin-1 (EC 3.6.5.5) (Dynamin) (Dynamin I) | 5 | UniProt NCBI |
| DNM3 | Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-177504 | 1.02652471053e-07 | 1.0 | DNM3 DNM2 DNM1 | Retrograde neurotrophin signalling |
| KEGG:04961 | 8.47057861986e-07 | 1.0 | DNM3 DNM2 DNM1 | Endocrine and other factor-regulated calcium reabsorption |
| WP:WP2267 | 9.56626957197e-07 | 1.0 | DNM3 DNM2 DNM1 | Synaptic vesicle pathway |
| KEGG:04721 | 1.78762380741e-06 | 1.0 | DNM3 DNM2 DNM1 | Synaptic vesicle cycle |
| KEGG:05100 | 3.67241243895e-06 | 1.0 | DNM3 DNM2 DNM1 | Bacterial invasion of epithelial cells |
| REAC:R-HSA-437239 | 7.08302050262e-06 | 1.0 | DNM3 DNM2 DNM1 | Recycling pathway of L1 |
| KEGG:04072 | 1.32405356583e-05 | 1.0 | DNM3 DNM2 DNM1 | Phospholipase D signaling pathway |
| REAC:R-HSA-187037 | 6.87958196908e-05 | 1.0 | DNM3 DNM2 DNM1 | Signaling by NTRK1 (TRKA) |
| REAC:R-HSA-373760 | 8.01155876351e-05 | 1.0 | DNM3 DNM2 DNM1 | L1CAM interactions |
| KEGG:04144 | 0.000105930292769 | 1.0 | DNM3 DNM2 DNM1 | Endocytosis |
| REAC:R-HSA-166520 | 0.000112201017269 | 1.0 | DNM3 DNM2 DNM1 | Signaling by NTRKs |
| REAC:R-HSA-2132295 | 0.000121377214977 | 1.0 | DNM3 DNM2 DNM1 | MHC class II antigen presentation |
| REAC:R-HSA-166016 | 0.000141203606556 | 1.0 | DNM3 DNM2 DNM1 | Toll Like Receptor 4 (TLR4) Cascade |
| REAC:R-HSA-8856828 | 0.00018294723391 | 1.0 | DNM3 DNM2 DNM1 | Clathrin-mediated endocytosis |
| REAC:R-HSA-168898 | 0.000217987188301 | 1.0 | DNM3 DNM2 DNM1 | Toll-like Receptor Cascades |
| REAC:R-HSA-196025 | 0.000374861161166 | 0.666666666667 | DNM2 DNM1 | Formation of annular gap junctions |
| REAC:R-HSA-190873 | 0.000449812862905 | 0.666666666667 | DNM2 DNM1 | Gap junction degradation |
| GO:0048488 | 0.00136394338287 | 1.0 | DNM3 DNM2 DNM1 | synaptic vesicle endocytosis |
| GO:0140238 | 0.00136394338287 | 1.0 | DNM3 DNM2 DNM1 | presynaptic endocytosis |
| GO:0036465 | 0.00238416149886 | 1.0 | DNM3 DNM2 DNM1 | synaptic vesicle recycling |
| REAC:R-HSA-190828 | 0.00504394814871 | 0.666666666667 | DNM2 DNM1 | Gap junction trafficking |
| REAC:R-HSA-157858 | 0.00530917647079 | 0.666666666667 | DNM2 DNM1 | Gap junction trafficking and regulation |
| REAC:R-HSA-9006934 | 0.00622622698696 | 1.0 | DNM3 DNM2 DNM1 | Signaling by Receptor Tyrosine Kinases |
| WP:WP4549 | 0.0067573392711 | 0.666666666667 | DNM2 DNM1 | Fragile X syndrome |
| REAC:R-HSA-422475 | 0.00865423788864 | 1.0 | DNM3 DNM2 DNM1 | Axon guidance |
| REAC:R-HSA-9675108 | 0.00966263043996 | 1.0 | DNM3 DNM2 DNM1 | Nervous system development |
| GO:0031623 | 0.0112921824257 | 1.0 | DNM3 DNM2 DNM1 | receptor internalization |
| REAC:R-HSA-199991 | 0.0145539954891 | 1.0 | DNM3 DNM2 DNM1 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.017135828319 | 1.0 | DNM3 DNM2 DNM1 | Vesicle-mediated transport |
| GO:0099504 | 0.0180186629002 | 1.0 | DNM3 DNM2 DNM1 | synaptic vesicle cycle |
| GO:0099003 | 0.019623483106 | 1.0 | DNM3 DNM2 DNM1 | vesicle-mediated transport in synapse |
| REAC:R-HSA-1280218 | 0.0226639223828 | 1.0 | DNM3 DNM2 DNM1 | Adaptive Immune System |
| REAC:R-HSA-1266738 | 0.0482660739102 | 1.0 | DNM3 DNM2 DNM1 | Developmental Biology |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| DNM2 | DNM3 | 1.0 | 0.896 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| DNM2 | DNM1 | 0.999 | 0.11 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| DNM1 | DNM3 | 0.999 | 0.158 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes