hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04028.1
Complex Portal: CPX-25043
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CDK5 | Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) | 5 | UniProt NCBI |
| CDK5R1 | Cyclin-dependent kinase 5 activator 1 (CDK5 activator 1) (Cyclin-dependent kinase 5 regulatory subunit 1) (TPKII regulatory subunit) [Cleaved into: Cyclin-dependent kinase 5 activator 1, p35 (p35); Cyclin-dependent kinase 5 activator 1, p25 (p25) (Tau protein kinase II 23 kDa subunit) (p23)] | 5 | UniProt NCBI |
| CCNI | Cyclin-I | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9032845 | 6.81752388431e-05 | 0.666666666667 | CDK5 CDK5R1 | Activated NTRK2 signals through CDK5 |
| KEGG:05030 | 0.000624850267462 | 0.666666666667 | CDK5 CDK5R1 | Cocaine addiction |
| REAC:R-HSA-399956 | 0.000715513386354 | 0.666666666667 | CDK5 CDK5R1 | CRMPs in Sema3A signaling |
| WP:WP3878 | 0.000927197171072 | 0.666666666667 | CDK5 CDK5R1 | ATM signaling in development and disease |
| REAC:R-HSA-9768919 | 0.00104246243986 | 0.666666666667 | CDK5 CDK5R1 | NPAS4 regulates expression of target genes |
| REAC:R-HSA-9006115 | 0.00104246243986 | 0.666666666667 | CDK5 CDK5R1 | Signaling by NTRK2 (TRKB) |
| GO:0016533 | 0.00140460216025 | 0.666666666667 | CDK5 CDK5R1 | protein kinase 5 complex |
| REAC:R-HSA-8863678 | 0.00143063482691 | 0.666666666667 | CDK5 CDK5R1 | Neurodegenerative Diseases |
| REAC:R-HSA-8862803 | 0.00143063482691 | 0.666666666667 | CDK5 CDK5R1 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
| REAC:R-HSA-9734009 | 0.00188000535098 | 0.666666666667 | CDK5 CDK5R1 | Defective Intrinsic Pathway for Apoptosis |
| GO:0000307 | 0.00252170927764 | 1.0 | CDK5 CCNI CDK5R1 | cyclin-dependent protein kinase holoenzyme complex |
| REAC:R-HSA-9634815 | 0.00257431960226 | 0.666666666667 | CDK5 CDK5R1 | Transcriptional Regulation by NPAS4 |
| REAC:R-HSA-9031628 | 0.0033773260227 | 0.666666666667 | CDK5 CDK5R1 | NGF-stimulated transcription |
| WP:WP2380 | 0.00845205977617 | 0.666666666667 | CDK5 CDK5R1 | Brain derived neurotrophic factor BDNF signaling pathway |
| REAC:R-HSA-198725 | 0.00973406489476 | 0.666666666667 | CDK5 CDK5R1 | Nuclear Events (kinase and transcription factor activation) |
| REAC:R-HSA-373755 | 0.0116360425406 | 0.666666666667 | CDK5 CDK5R1 | Semaphorin interactions |
| REAC:R-HSA-6804756 | 0.0265950995478 | 0.666666666667 | CDK5 CDK5R1 | Regulation of TP53 Activity through Phosphorylation |
| REAC:R-HSA-9645723 | 0.0278082114556 | 0.666666666667 | CDK5 CDK5R1 | Diseases of programmed cell death |
| WP:WP2059 | 0.0297769620239 | 0.666666666667 | CDK5 CDK5R1 | Alzheimer 39 s disease and miRNA effects |
| WP:WP5124 | 0.0297769620239 | 0.666666666667 | CDK5 CDK5R1 | Alzheimer 39 s disease |
| GO:1902554 | 0.0312870733704 | 1.0 | CDK5 CCNI CDK5R1 | serine/threonine protein kinase complex |
| REAC:R-HSA-187037 | 0.0316091445651 | 0.666666666667 | CDK5 CDK5R1 | Signaling by NTRK1 (TRKA) |
| KEGG:05010 | 0.0433146801558 | 0.666666666667 | CDK5 CDK5R1 | Alzheimer disease |
| REAC:R-HSA-166520 | 0.0436932800731 | 0.666666666667 | CDK5 CDK5R1 | Signaling by NTRKs |
| GO:1902911 | 0.0458676185213 | 1.0 | CDK5 CCNI CDK5R1 | protein kinase complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CDK5 | CDK5R1 | 0.999 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CDK5 | CCNI | 0.993 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes