hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04033.1
Complex Portal: CPX-15300
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PRPF8 | Pre-mRNA-processing-splicing factor 8 (220 kDa U5 snRNP-specific protein) (PRP8 homolog) (Splicing factor Prp8) (p220) | 5 | UniProt NCBI |
| SNRNP200 | U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.4.13) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog) (U5 snRNP-specific 200 kDa protein) (U5-200KD) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1335 | 0.000179419983974 | 1.0 | PRPF8 SNRNP200 | SNW1 complex |
| KEGG:03040 | 0.00125991513217 | 1.0 | PRPF8 SNRNP200 | Spliceosome |
| REAC:R-HSA-72165 | 0.0019274832564 | 1.0 | PRPF8 SNRNP200 | mRNA Splicing - Minor Pathway |
| CORUM:1181 | 0.00499983688673 | 1.0 | PRPF8 SNRNP200 | C complex spliceosome |
| HP:0007675 | 0.00873519007688 | 1.0 | PRPF8 SNRNP200 | Progressive night blindness |
| HP:0030786 | 0.00973994198714 | 1.0 | PRPF8 SNRNP200 | Photopsia |
| HP:0007994 | 0.00999967377346 | 1.0 | PRPF8 SNRNP200 | Peripheral visual field loss |
| HP:0007787 | 0.0113495955576 | 1.0 | PRPF8 SNRNP200 | Posterior subcapsular cataract |
| HP:0007737 | 0.0127849554294 | 1.0 | PRPF8 SNRNP200 | Bone spicule pigmentation of the retina |
| HP:0000563 | 0.0130822799743 | 1.0 | PRPF8 SNRNP200 | Keratoconus |
| HP:0000523 | 0.0136871816346 | 1.0 | PRPF8 SNRNP200 | Subcapsular cataract |
| HP:0100692 | 0.0139947587499 | 1.0 | PRPF8 SNRNP200 | Increased corneal curvature |
| HP:0100689 | 0.0143057533888 | 1.0 | PRPF8 SNRNP200 | Decreased corneal thickness |
| HP:0011486 | 0.0159119894358 | 1.0 | PRPF8 SNRNP200 | Abnormality of corneal thickness |
| CORUM:351 | 0.0159188244828 | 1.0 | PRPF8 SNRNP200 | Spliceosome |
| HP:0007843 | 0.0176036635704 | 1.0 | PRPF8 SNRNP200 | Attenuation of retinal blood vessels |
| HP:0001133 | 0.0208639809935 | 1.0 | PRPF8 SNRNP200 | Constriction of peripheral visual field |
| HPA:0060853 | 0.0215312151197 | 1.0 | PRPF8 SNRNP200 | bronchus; ciliated cells (cell body)[High] |
| HP:0000842 | 0.0227948817734 | 1.0 | PRPF8 SNRNP200 | Hyperinsulinemia |
| HPA:0320853 | 0.02350632407 | 1.0 | PRPF8 SNRNP200 | nasopharynx; ciliated cells (cell body)[High] |
| HP:0040214 | 0.0252247409849 | 1.0 | PRPF8 SNRNP200 | Abnormal circulating insulin concentration |
| GO:0071012 | 0.0309012475255 | 1.0 | PRPF8 SNRNP200 | catalytic step 1 spliceosome |
| GO:0071006 | 0.0309012475255 | 1.0 | PRPF8 SNRNP200 | U2-type catalytic step 1 spliceosome |
| REAC:R-HSA-72163 | 0.0343461112178 | 1.0 | PRPF8 SNRNP200 | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 0.0367862229998 | 1.0 | PRPF8 SNRNP200 | mRNA Splicing |
| HP:0000580 | 0.0440177027348 | 1.0 | PRPF8 SNRNP200 | Pigmentary retinopathy |
| HP:0000512 | 0.0473702932925 | 1.0 | PRPF8 SNRNP200 | Abnormal electroretinogram |
| CORUM:1195 | 0.0499419797295 | 0.5 | PRPF8 | Exon junction complex (mRNA splicing-dependent) |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PRPF8 | SNRNP200 | 1.0 | 0.994 | hein_WMM bioplex_WMM Guru bioplex3_WMM boldt Malo gupta_WMM fraction boldt_WMM treiber_WMM |
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