hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_04039.1
Complex Portal: CPX-24943
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EPC1 | Enhancer of polycomb homolog 1 | 5 | UniProt NCBI |
| MBTD1 | MBT domain-containing protein 1 | 5 | UniProt NCBI |
| EPC2 | Enhancer of polycomb homolog 2 (EPC-like) | 4 | UniProt NCBI |
| MYCL | Protein L-Myc (Class E basic helix-loop-helix protein 38) (bHLHe38) (Protein L-Myc-1) (V-myc myelocytomatosis viral oncogene homolog) | 5 | UniProt NCBI |
| TRRAP | Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog) | 5 | UniProt NCBI |
| EP400 | E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein) | 5 | UniProt NCBI |
| YEATS4 | YEATS domain-containing protein 4 (Glioma-amplified sequence 41) (Gas41) (NuMA-binding protein 1) (NuBI-1) (NuBI1) | 5 | UniProt NCBI |
| ING3 | Inhibitor of growth protein 3 (p47ING3) | 5 | UniProt NCBI |
| MEAF6 | Chromatin modification-related protein MEAF6 (MYST/Esa1-associated factor 6) (Esa1-associated factor 6 homolog) (Protein EAF6 homolog) (hEAF6) (Sarcoma antigen NY-SAR-91) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2857 | 8.87375631601e-20 | 0.875 | TRRAP YEATS4 EP400 EPC2 EPC1 ING3 MEAF6 | NuA4/Tip60 HAT complex |
| CORUM:798 | 1.66372960626e-19 | 0.875 | TRRAP YEATS4 EP400 EPC2 EPC1 ING3 MEAF6 | NuA4/Tip60-HAT complex A |
| GO:0035267 | 3.01597566675e-18 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | NuA4 histone acetyltransferase complex |
| GO:0043189 | 3.01597566675e-18 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | H4/H2A histone acetyltransferase complex |
| GO:1905168 | 1.34726068294e-17 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | positive regulation of double-strand break repair via homologous recombination |
| GO:1902562 | 1.14531576605e-16 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | H4 histone acetyltransferase complex |
| GO:0045911 | 3.05136458758e-16 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | positive regulation of DNA recombination |
| CORUM:528 | 9.44665679296e-16 | 0.75 | TRRAP YEATS4 EP400 MEAF6 ING3 EPC1 | NuA4/Tip60-HAT complex |
| CORUM:529 | 1.51128763302e-15 | 0.75 | TRRAP YEATS4 EP400 MEAF6 ING3 EPC1 | NuA4/Tip60-HAT complex |
| GO:0010569 | 4.89776888676e-15 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | regulation of double-strand break repair via homologous recombination |
| GO:2000781 | 2.27518772716e-14 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | positive regulation of double-strand break repair |
| GO:0000786 | 2.53154690769e-14 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | nucleosome |
| GO:0000123 | 6.2371642259e-14 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | histone acetyltransferase complex |
| GO:1902493 | 1.52701849767e-13 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | acetyltransferase complex |
| GO:0031248 | 1.52701849767e-13 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | protein acetyltransferase complex |
| GO:0000018 | 2.12794802567e-13 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | regulation of DNA recombination |
| KEGG:03082 | 2.96410576621e-13 | 0.875 | TRRAP YEATS4 EP400 EPC2 EPC1 ING3 MEAF6 | ATP-dependent chromatin remodeling |
| GO:0045739 | 8.15355168909e-13 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | positive regulation of DNA repair |
| GO:2000779 | 8.15355168909e-13 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | regulation of double-strand break repair |
| GO:0000724 | 7.80651773389e-12 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | double-strand break repair via homologous recombination |
| GO:0000725 | 9.57817265423e-12 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | recombinational repair |
| GO:0006282 | 4.53535566753e-11 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | regulation of DNA repair |
| GO:0051054 | 2.27601154371e-10 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | positive regulation of DNA metabolic process |
| GO:0006310 | 2.97337388537e-10 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | DNA recombination |
| GO:0006302 | 6.1215431246e-10 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | double-strand break repair |
| CORUM:2856 | 7.0490440398e-10 | 0.5 | TRRAP ING3 EPC1 EP400 | NuA4/Tip60 HAT complex |
| REAC:R-HSA-3214847 | 2.47017611317e-09 | 0.75 | TRRAP YEATS4 EP400 MEAF6 ING3 EPC1 | HATs acetylate histones |
| GO:0080135 | 1.35540696923e-08 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | regulation of cellular response to stress |
| GO:0051052 | 2.01720321005e-08 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | regulation of DNA metabolic process |
| GO:0006281 | 6.83784514631e-08 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | DNA repair |
| REAC:R-HSA-4839726 | 1.36640407401e-07 | 0.75 | TRRAP YEATS4 EP400 MEAF6 ING3 EPC1 | Chromatin organization |
| REAC:R-HSA-3247509 | 1.36640407401e-07 | 0.75 | TRRAP YEATS4 EP400 MEAF6 ING3 EPC1 | Chromatin modifying enzymes |
| CORUM:799 | 1.17658221023e-06 | 0.375 | TRRAP EPC1 EP400 | DMAP1-associated complex |
| GO:0006974 | 1.63460050162e-06 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | DNA damage response |
| GO:0006259 | 2.69271014008e-06 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | DNA metabolic process |
| GO:1990234 | 3.08374833897e-06 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | transferase complex |
| GO:0051726 | 4.66150967003e-06 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | regulation of cell cycle |
| GO:0140535 | 4.89541721592e-06 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | intracellular protein-containing complex |
| GO:0042981 | 7.79037061364e-06 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | regulation of apoptotic process |
| GO:0043067 | 1.04984758657e-05 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | regulation of programmed cell death |
| GO:0080134 | 1.60331369638e-05 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | regulation of response to stress |
| GO:0000785 | 1.86294016049e-05 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | chromatin |
| GO:0032777 | 2.15253635486e-05 | 0.375 | ING3 EPC1 EPC2 | piccolo histone acetyltransferase complex |
| GO:0032993 | 2.98990668125e-05 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | protein-DNA complex |
| GO:0045893 | 3.48847463157e-05 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | positive regulation of DNA-templated transcription |
| GO:1902680 | 3.56920766799e-05 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | positive regulation of RNA biosynthetic process |
| GO:0006915 | 4.67349462189e-05 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | apoptotic process |
| GO:0012501 | 6.84099448176e-05 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | programmed cell death |
| GO:0008219 | 7.08485622309e-05 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | cell death |
| GO:0051254 | 8.71423334923e-05 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | positive regulation of RNA metabolic process |
| GO:0007049 | 0.00014575641922 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | cell cycle |
| GO:0033554 | 0.000180586151088 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | cellular response to stress |
| GO:0045935 | 0.000252424773977 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | positive regulation of nucleobase-containing compound metabolic process |
| GO:0005694 | 0.000342186376989 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | chromosome |
| CORUM:1166 | 0.000358447219737 | 0.25 | TRRAP EP400 | p400-associated complex |
| CORUM:787 | 0.000668735194034 | 0.25 | TRRAP EPC1 | NuA4/Tip60-HAT complex B |
| GO:1902494 | 0.000702145526577 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | catalytic complex |
| GO:0048584 | 0.000775284087387 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | positive regulation of response to stimulus |
| GO:0010557 | 0.00142483782636 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | positive regulation of macromolecule biosynthetic process |
| GO:0000812 | 0.00153551162834 | 0.375 | TRRAP EP400 ING3 | Swr1 complex |
| GO:0031328 | 0.00180523733988 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | positive regulation of cellular biosynthetic process |
| GO:0009891 | 0.00189994587755 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | positive regulation of biosynthetic process |
| GO:0051173 | 0.00752120883806 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | positive regulation of nitrogen compound metabolic process |
| GO:0097346 | 0.0156477314671 | 0.375 | TRRAP EP400 ING3 | INO80-type complex |
| GO:0031325 | 0.0159488079161 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | positive regulation of cellular metabolic process |
| GO:0006355 | 0.019276917338 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | regulation of DNA-templated transcription |
| GO:2001141 | 0.0202331041081 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | regulation of RNA biosynthetic process |
| GO:0010604 | 0.0203029637684 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | positive regulation of macromolecule metabolic process |
| GO:0006351 | 0.0281694782025 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | DNA-templated transcription |
| GO:0032774 | 0.0306853042962 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | RNA biosynthetic process |
| GO:0006950 | 0.0341601246885 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | response to stress |
| GO:0009893 | 0.0414980370851 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | positive regulation of metabolic process |
| GO:0051252 | 0.0471731106254 | 1.0 | TRRAP YEATS4 EP400 EPC2 MBTD1 EPC1 ING3 MEAF6 | regulation of RNA metabolic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| EPC2 | ING3 | 0.999 | 0.228 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () | |
| EPC1 | ING3 | 0.999 | 0.208 |
mutually_exclusive (Q9HAF1)
|
hein_WMM bioplex_WMM bioplex3_WMM hein () |
| TRRAP | EP400 | 0.999 | hein_WMM bioplex_WMM Guru bioplex3_WMM youn_WMM hein () fraction | ||
| EP400 | ING3 | 0.999 | hein_WMM bioplex_WMM bioplex3_WMM hein () | ||
| MEAF6 | EP400 | 0.999 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| MBTD1 | ING3 | 0.999 | 0.184 |
mutually_exclusive (O95619)
|
hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| MBTD1 | EPC2 | 0.999 | 0.21 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TRRAP | EPC1 | 0.999 | 0.34 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| MEAF6 | EPC1 | 0.999 | 0.21 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| EPC2 | EP400 | 0.999 | hein_WMM bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM youn_WMM bioplex3_HCT116 fraction | ||
| TRRAP | ING3 | 0.999 | 0.411 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| EPC1 | EPC2 | 0.999 | 0.366 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| TRRAP | MBTD1 | 0.999 | 0.342 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| EPC1 | EP400 | 0.999 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | ||
| EPC2 | YEATS4 | 0.999 | 0.192 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | |
| MEAF6 | ING3 | 0.999 | 0.158 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| MEAF6 | MBTD1 | 0.998 | 0.288 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MBTD1 | EP400 | 0.998 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | ||
| EPC1 | MBTD1 | 0.998 | 0.16 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| MEAF6 | EPC2 | 0.998 | 0.166 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| EP400 | YEATS4 | 0.998 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM hein () fraction | ||
| MBTD1 | YEATS4 | 0.995 | 0.139684210526 |
structurally_consistent (Q96A08)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
| EPC1 | YEATS4 | 0.995 | 0.154 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () | |
| TRRAP | EPC2 | 0.995 | 0.258 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | |
| TRRAP | MEAF6 | 0.994 | 0.55 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| YEATS4 | ING3 | 0.993 | 0.292 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
| MEAF6 | YEATS4 | 0.99 | 0.364 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TRRAP | YEATS4 | 0.989 | 0.332 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () | |
| MYCL | ING3 | 0.985 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| MYCL | EPC1 | 0.985 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| TRRAP | MYCL | 0.985 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| MYCL | MEAF6 | 0.984 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| MYCL | EP400 | 0.984 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | ||
| MYCL | EPC2 | 0.981 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| MYCL | YEATS4 | 0.981 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| MYCL | MBTD1 | 0.981 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes