hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_04043.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DOK2 | Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)) | 5 | UniProt NCBI |
| RGPD4 | RanBP2-like and GRIP domain-containing protein 4 | 3 | UniProt NCBI |
| PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8853659 | 0.00296224002415 | 0.666666666667 | DOK2 PLCG1 | RET signaling |
| WP:WP437 | 0.0115871748317 | 0.666666666667 | DOK2 PLCG1 | EGF EGFR signaling pathway |
| CORUM:2960 | 0.0249718442456 | 0.333333333333 | PLCG1 | SLP-76-PLC-gamma-1-ITK complex, alpha-TCR stimulated |
| CORUM:2961 | 0.0249718442456 | 0.333333333333 | PLCG1 | SLP-76-PLC-gamma-1-VAV complex, alpha-TCR stimulated |
| REAC:R-HSA-202733 | 0.0349616412881 | 0.666666666667 | DOK2 PLCG1 | Cell surface interactions at the vascular wall |
| REAC:R-HSA-167021 | 0.0498224659464 | 0.333333333333 | PLCG1 | PLC-gamma1 signalling |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| DOK2 | PLCG1 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| DOK2 | RGPD4 | 0.986 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RGPD4 | PLCG1 | 0.143 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes