hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04051.1
Complex Portal: CPX-21099
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| YWHAH | 14-3-3 protein eta (Protein AS1) | 5 | UniProt NCBI |
| CIC | Protein capicua homolog | 5 | UniProt NCBI |
| GRID2IP | Delphilin (Glutamate receptor, ionotropic, delta 2-interacting protein 1) | 3 | UniProt NCBI |
| CRTC1 | CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1) (Transducer of regulated cAMP response element-binding protein 1) (TORC-1) (Transducer of CREB protein 1) | 5 | UniProt NCBI |
| WEE1 | Wee1-like protein kinase (WEE1hu) (EC 2.7.10.2) (Wee1A kinase) | 5 | UniProt NCBI |
| ERRFI1 | ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein) (MIG-6) | 5 | UniProt NCBI |
| SASH1 | SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) | 5 | UniProt NCBI |
| FOXO4 | Forkhead box protein O4 (Fork head domain transcription factor AFX1) | 5 | UniProt NCBI |
| FOXO3 | Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP2261 | 0.000704977993915 | 0.375 | ERRFI1 FOXO4 FOXO3 | Glioblastoma signaling pathways |
| REAC:R-HSA-198693 | 0.00250486048439 | 0.25 | FOXO3 FOXO4 | AKT phosphorylates targets in the nucleus |
| REAC:R-HSA-9617629 | 0.00250486048439 | 0.25 | FOXO3 FOXO4 | Regulation of FOXO transcriptional activity by acetylation |
| REAC:R-HSA-9614399 | 0.00367178411278 | 0.25 | FOXO3 FOXO4 | Regulation of localization of FOXO transcription factors |
| REAC:R-HSA-9617828 | 0.00666866305696 | 0.25 | FOXO3 FOXO4 | FOXO-mediated transcription of cell cycle genes |
| REAC:R-HSA-9614657 | 0.00666866305696 | 0.25 | FOXO3 FOXO4 | FOXO-mediated transcription of cell death genes |
| WP:WP4542 | 0.00964105812378 | 0.25 | FOXO3 FOXO4 | Leukocyte intrinsic Hippo pathway functions |
| WP:WP3844 | 0.0103268762936 | 0.25 | FOXO3 FOXO4 | PI3K AKT mTOR signaling pathway and therapeutic opportunities in prostate cancer |
| REAC:R-HSA-5674400 | 0.0166306183768 | 0.25 | FOXO3 FOXO4 | Constitutive Signaling by AKT1 E17K in Cancer |
| REAC:R-HSA-9615017 | 0.0166306183768 | 0.25 | FOXO3 FOXO4 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| FOXO3 | YWHAH | 0.988 | 0.24 | bioplex3_HEK293 bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only | |
| SASH1 | YWHAH | 0.974 | 0.292 | bioplex3_HEK293 bioplex3_WMM boldt_WMM WMM_only | |
| ERRFI1 | YWHAH | 0.972 | 0.428592592593 |
mutually_exclusive (P27348)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| CRTC1 | YWHAH | 0.971 | 0.153561845286 |
mutually_exclusive (P27348)
|
bioplex3_HEK293 bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only |
| CIC | YWHAH | 0.96 | 0.174714285714 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| YWHAH | GRID2IP | 0.956 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| YWHAH | WEE1 | 0.956 | 0.222523809524 | bioplex3_HEK293 bioplex3_WMM boldt boldt_WMM WMM_only | |
| YWHAH | FOXO4 | 0.954 |
mutually_exclusive (P31947)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| CRTC1 | FOXO3 | 0.543 | 0.208 | bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only | |
| SASH1 | FOXO3 | 0.539 | 0.126 | bioplex3_WMM WMM_only boldt_WMM | |
| CRTC1 | SASH1 | 0.539 | 0.1 |
mutually_exclusive (P27348)
|
bioplex3_WMM WMM_only boldt_WMM |
| CIC | CRTC1 | 0.428 | 0.142 | bioplex3_WMM WMM_only | |
| CIC | FOXO3 | 0.391 | 0.142 | bioplex3_WMM WMM_only | |
| FOXO3 | FOXO4 | 0.324 | bioplex3_WMM WMM_only | ||
| SASH1 | GRID2IP | 0.319 | bioplex3_WMM WMM_only | ||
| SASH1 | FOXO4 | 0.283 | bioplex3_WMM WMM_only | ||
| FOXO3 | GRID2IP | 0.283 | bioplex3_WMM WMM_only | ||
| CRTC1 | FOXO4 | 0.283 | bioplex3_WMM WMM_only | ||
| CRTC1 | GRID2IP | 0.283 | bioplex3_WMM WMM_only | ||
| GRID2IP | FOXO4 | 0.283 | bioplex3_WMM WMM_only | ||
| FOXO3 | WEE1 | 0.269 | 0.156 | bioplex3_WMM boldt boldt_WMM WMM_only | |
| CIC | FOXO4 | 0.247 | bioplex3_WMM WMM_only | ||
| CIC | SASH1 | 0.247 | 0.052 | bioplex3_WMM WMM_only | |
| CIC | GRID2IP | 0.247 | bioplex3_WMM WMM_only | ||
| SASH1 | WEE1 | 0.196 | 0.096 | bioplex3_WMM WMM_only boldt_WMM | |
| CRTC1 | WEE1 | 0.157 | 0.152 | bioplex3_WMM boldt boldt_WMM WMM_only | |
| GRID2IP | WEE1 | 0.079 | bioplex3_WMM WMM_only | ||
| ERRFI1 | WEE1 | 0.079 | 0.082 | bioplex3_WMM WMM_only | |
| CRTC1 | ERRFI1 | 0.079 | 0.058 |
mutually_exclusive (P27348)
|
bioplex3_WMM WMM_only |
| ERRFI1 | GRID2IP | 0.079 | bioplex3_WMM WMM_only | ||
| WEE1 | FOXO4 | 0.079 | bioplex3_WMM WMM_only | ||
| ERRFI1 | FOXO4 | 0.079 |
mutually_exclusive (P31947)
|
bioplex3_WMM WMM_only | |
| ERRFI1 | SASH1 | 0.079 | 0.072 |
mutually_exclusive (P27348)
|
bioplex3_WMM WMM_only |
| CIC | WEE1 | 0.079 | 0.114 | bioplex3_WMM WMM_only | |
| ERRFI1 | FOXO3 | 0.079 | 0.08 | bioplex3_WMM WMM_only | |
| CIC | ERRFI1 | 0.079 | 0.098 | bioplex3_WMM WMM_only |
Related Complexes