hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04053.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CENPO | Centromere protein O (CENP-O) (Interphase centromere complex protein 36) | 5 | UniProt NCBI |
| ITGB3BP | Centromere protein R (CENP-R) (Beta-3-endonexin) (Integrin beta-3-binding protein) (Nuclear receptor-interacting factor 3) | 5 | UniProt NCBI |
| CENPT | Centromere protein T (CENP-T) (Interphase centromere complex protein 22) | 5 | UniProt NCBI |
| CENPQ | Centromere protein Q (CENP-Q) | 5 | UniProt NCBI |
| CENPP | Centromere protein P (CENP-P) | 5 | UniProt NCBI |
| CENPX | Centromere protein X (CENP-X) (FANCM-associated histone fold protein 2) (FANCM-interacting histone fold protein 2) (Fanconi anemia-associated polypeptide of 10 kDa) (Retinoic acid-inducible gene D9 protein homolog) (Stimulated by retinoic acid gene 13 protein homolog) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0000939 | 2.96127975816e-14 | 1.0 | ITGB3BP CENPO CENPX CENPQ CENPP CENPT | inner kinetochore |
| CORUM:1179 | 1.6910019057e-13 | 0.833333333333 | CENPQ ITGB3BP CENPP CENPO CENPT | CENP-A NAC-CAD complex |
| REAC:R-HSA-606279 | 7.54880047195e-13 | 1.0 | ITGB3BP CENPO CENPX CENPQ CENPP CENPT | Deposition of new CENPA-containing nucleosomes at the centromere |
| REAC:R-HSA-774815 | 7.54880047195e-13 | 1.0 | ITGB3BP CENPO CENPX CENPQ CENPP CENPT | Nucleosome assembly |
| REAC:R-HSA-73886 | 7.02788877184e-11 | 1.0 | ITGB3BP CENPO CENPX CENPQ CENPP CENPT | Chromosome Maintenance |
| CORUM:7394 | 3.16661070301e-10 | 0.666666666667 | ITGB3BP CENPP CENPO CENPQ | CENP-H-I complex |
| REAC:R-HSA-141444 | 9.71939783595e-09 | 0.833333333333 | CENPQ ITGB3BP CENPP CENPO CENPT | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| REAC:R-HSA-141424 | 9.71939783595e-09 | 0.833333333333 | CENPQ ITGB3BP CENPP CENPO CENPT | Amplification of signal from the kinetochores |
| REAC:R-HSA-69618 | 2.20106305465e-08 | 0.833333333333 | CENPQ ITGB3BP CENPP CENPO CENPT | Mitotic Spindle Checkpoint |
| REAC:R-HSA-9648025 | 2.77083374341e-08 | 0.833333333333 | CENPQ ITGB3BP CENPP CENPO CENPT | EML4 and NUDC in mitotic spindle formation |
| GO:0000776 | 3.03911050457e-08 | 1.0 | ITGB3BP CENPO CENPX CENPQ CENPP CENPT | kinetochore |
| GO:0000779 | 3.62345930083e-08 | 1.0 | ITGB3BP CENPO CENPX CENPQ CENPP CENPT | condensed chromosome, centromeric region |
| REAC:R-HSA-2500257 | 3.92241770227e-08 | 0.833333333333 | CENPQ ITGB3BP CENPP CENPO CENPT | Resolution of Sister Chromatid Cohesion |
| REAC:R-HSA-5663220 | 6.09938804447e-08 | 0.833333333333 | CENPQ ITGB3BP CENPP CENPO CENPT | RHO GTPases Activate Formins |
| GO:0000775 | 2.69530051772e-07 | 1.0 | ITGB3BP CENPO CENPX CENPQ CENPP CENPT | chromosome, centromeric region |
| REAC:R-HSA-2467813 | 3.27107065443e-07 | 0.833333333333 | CENPQ ITGB3BP CENPP CENPO CENPT | Separation of Sister Chromatids |
| GO:0000793 | 3.43700038981e-07 | 1.0 | ITGB3BP CENPO CENPX CENPQ CENPP CENPT | condensed chromosome |
| REAC:R-HSA-68877 | 4.38380679568e-07 | 0.833333333333 | CENPQ ITGB3BP CENPP CENPO CENPT | Mitotic Prometaphase |
| REAC:R-HSA-68882 | 8.61664691998e-07 | 0.833333333333 | CENPQ ITGB3BP CENPP CENPO CENPT | Mitotic Anaphase |
| REAC:R-HSA-2555396 | 8.81286498696e-07 | 0.833333333333 | CENPQ ITGB3BP CENPP CENPO CENPT | Mitotic Metaphase and Anaphase |
| REAC:R-HSA-1640170 | 1.35326345786e-06 | 1.0 | ITGB3BP CENPO CENPX CENPQ CENPP CENPT | Cell Cycle |
| REAC:R-HSA-69620 | 2.65695981632e-06 | 0.833333333333 | CENPQ ITGB3BP CENPP CENPO CENPT | Cell Cycle Checkpoints |
| REAC:R-HSA-195258 | 3.57518038163e-06 | 0.833333333333 | CENPQ ITGB3BP CENPP CENPO CENPT | RHO GTPase Effectors |
| GO:0098687 | 5.16210966857e-06 | 1.0 | ITGB3BP CENPO CENPX CENPQ CENPP CENPT | chromosomal region |
| GO:0007059 | 5.56613947916e-06 | 1.0 | ITGB3BP CENPO CENPX CENPQ CENPP CENPT | chromosome segregation |
| REAC:R-HSA-68886 | 1.36954749952e-05 | 0.833333333333 | CENPQ ITGB3BP CENPP CENPO CENPT | M Phase |
| REAC:R-HSA-69278 | 6.34457226533e-05 | 0.833333333333 | CENPQ ITGB3BP CENPP CENPO CENPT | Cell Cycle, Mitotic |
| CORUM:6146 | 0.000102488289015 | 0.333333333333 | CENPX CENPT | CENP-T-W-S-X heterotetramer complex |
| REAC:R-HSA-194315 | 0.000155913328362 | 0.833333333333 | CENPQ ITGB3BP CENPP CENPO CENPT | Signaling by Rho GTPases |
| REAC:R-HSA-9716542 | 0.000173940466834 | 0.833333333333 | CENPQ ITGB3BP CENPP CENPO CENPT | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 |
| GO:0099080 | 0.00221939891188 | 1.0 | ITGB3BP CENPO CENPX CENPQ CENPP CENPT | supramolecular complex |
| GO:0022402 | 0.00448042793636 | 1.0 | ITGB3BP CENPO CENPX CENPQ CENPP CENPT | cell cycle process |
| GO:0007049 | 0.0199235391889 | 1.0 | ITGB3BP CENPO CENPX CENPQ CENPP CENPT | cell cycle |
| GO:0005694 | 0.0377686998201 | 1.0 | ITGB3BP CENPO CENPX CENPQ CENPP CENPT | chromosome |
| REAC:R-HSA-162582 | 0.0495022563739 | 0.833333333333 | CENPQ ITGB3BP CENPP CENPO CENPT | Signal Transduction |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CENPO | CENPP | 1.0 | 0.376 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| ITGB3BP | CENPP | 1.0 | 0.298 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| CENPQ | CENPP | 1.0 | 0.302 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| CENPO | ITGB3BP | 0.999 | 0.218 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
| CENPO | CENPQ | 0.999 | 0.462 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| ITGB3BP | CENPQ | 0.999 | 0.302 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
| ITGB3BP | CENPT | 0.998 | 0.156 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
| CENPO | CENPT | 0.997 | 0.36 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
| CENPT | CENPQ | 0.996 | 0.172 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
| CENPQ | CENPX | 0.994 | 0.124 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
| CENPO | CENPX | 0.994 | 0.156 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
| ITGB3BP | CENPX | 0.993 | 0.106 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| CENPP | CENPX | 0.991 | 0.152 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| CENPT | CENPP | 0.984 | 0.138 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| CENPT | CENPX | 0.764 | 0.166 | hein_WMM WMM_only |
Related Complexes