hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04054.1
Complex Portal: CPX-19778
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EXOC6B | Exocyst complex component 6B (Exocyst complex component Sec15B) (SEC15-like protein 2) | 5 | UniProt NCBI |
| EXOC1 | Exocyst complex component 1 (Exocyst complex component Sec3) | 5 | UniProt NCBI |
| EXOC2 | Exocyst complex component 2 (Exocyst complex component Sec5) | 5 | UniProt NCBI |
| EXOC7 | Exocyst complex component 7 (Exocyst complex component Exo70) | 5 | UniProt NCBI |
| EXOC8 | Exocyst complex component 8 (Exocyst complex 84 kDa subunit) | 5 | UniProt NCBI |
| KRT86 | Keratin, type II cuticular Hb6 (Hair keratin K2.11) (Keratin-86) (K86) (Type II hair keratin Hb6) (Type-II keratin Kb26) | 5 | UniProt NCBI |
| EXOC4 | Exocyst complex component 4 (Exocyst complex component Sec8) | 5 | UniProt NCBI |
| EXOC5 | Exocyst complex component 5 (Exocyst complex component Sec10) (hSec10) | 5 | UniProt NCBI |
| EXOC3 | Exocyst complex component 3 (Exocyst complex component Sec6) | 5 | UniProt NCBI |
| EXOC6 | Exocyst complex component 6 (Exocyst complex component Sec15A) (SEC15-like protein 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0090522 | 5.9787945705e-27 | 0.9 | EXOC4 EXOC5 EXOC2 EXOC7 EXOC6 EXOC1 EXOC3 EXOC8 EXOC6B | vesicle tethering involved in exocytosis |
| CORUM:6167 | 6.37461695557e-26 | 0.8 | EXOC4 EXOC5 EXOC2 EXOC1 EXOC7 EXOC6 EXOC8 EXOC3 | Exocyst complex |
| CORUM:89 | 6.37461695557e-26 | 0.8 | EXOC4 EXOC5 EXOC2 EXOC1 EXOC7 EXOC6 EXOC8 EXOC3 | Exocyst Sec6/8 complex |
| GO:0000145 | 1.19658590018e-23 | 0.9 | EXOC4 EXOC5 EXOC2 EXOC7 EXOC6 EXOC1 EXOC3 EXOC8 EXOC6B | exocyst |
| REAC:R-HSA-5620916 | 9.21940811967e-21 | 0.8 | EXOC4 EXOC5 EXOC2 EXOC1 EXOC7 EXOC6 EXOC8 EXOC3 | VxPx cargo-targeting to cilium |
| REAC:R-HSA-264876 | 4.28578088423e-20 | 0.8 | EXOC4 EXOC5 EXOC2 EXOC1 EXOC7 EXOC6 EXOC8 EXOC3 | Insulin processing |
| GO:0099022 | 8.54288235729e-20 | 0.9 | EXOC4 EXOC5 EXOC2 EXOC7 EXOC6 EXOC1 EXOC3 EXOC8 EXOC6B | vesicle tethering |
| GO:0006904 | 4.21471183856e-19 | 0.9 | EXOC4 EXOC5 EXOC2 EXOC7 EXOC6 EXOC1 EXOC3 EXOC8 EXOC6B | vesicle docking involved in exocytosis |
| GO:0090148 | 2.09050202434e-18 | 0.9 | EXOC4 EXOC5 EXOC2 EXOC7 EXOC6 EXOC1 EXOC3 EXOC8 EXOC6B | membrane fission |
| GO:0140029 | 3.170668663e-17 | 0.9 | EXOC4 EXOC5 EXOC2 EXOC7 EXOC6 EXOC1 EXOC3 EXOC8 EXOC6B | exocytic process |
| GO:0048278 | 3.170668663e-17 | 0.9 | EXOC4 EXOC5 EXOC2 EXOC7 EXOC6 EXOC1 EXOC3 EXOC8 EXOC6B | vesicle docking |
| GO:0006903 | 5.36289128407e-17 | 0.9 | EXOC4 EXOC5 EXOC2 EXOC7 EXOC6 EXOC1 EXOC3 EXOC8 EXOC6B | vesicle targeting |
| REAC:R-HSA-5620920 | 5.47888396148e-17 | 0.8 | EXOC4 EXOC5 EXOC2 EXOC1 EXOC7 EXOC6 EXOC8 EXOC3 | Cargo trafficking to the periciliary membrane |
| GO:0099023 | 1.03350624796e-16 | 0.9 | EXOC4 EXOC5 EXOC2 EXOC7 EXOC6 EXOC1 EXOC3 EXOC8 EXOC6B | vesicle tethering complex |
| GO:0140056 | 2.93564241108e-16 | 0.9 | EXOC4 EXOC5 EXOC2 EXOC7 EXOC6 EXOC1 EXOC3 EXOC8 EXOC6B | organelle localization by membrane tethering |
| GO:0022406 | 9.60473070383e-16 | 0.9 | EXOC4 EXOC5 EXOC2 EXOC7 EXOC6 EXOC1 EXOC3 EXOC8 EXOC6B | membrane docking |
| REAC:R-HSA-2980736 | 1.20305437034e-15 | 0.8 | EXOC4 EXOC5 EXOC2 EXOC1 EXOC7 EXOC6 EXOC8 EXOC3 | Peptide hormone metabolism |
| GO:0000281 | 1.38041848791e-15 | 0.9 | EXOC4 EXOC5 EXOC2 EXOC7 EXOC6 EXOC1 EXOC3 EXOC8 EXOC6B | mitotic cytokinesis |
| REAC:R-HSA-1445148 | 1.75075679242e-15 | 0.8 | EXOC4 EXOC5 EXOC2 EXOC1 EXOC7 EXOC6 EXOC8 EXOC3 | Translocation of SLC2A4 (GLUT4) to the plasma membrane |
| WP:WP5366 | 1.12762299264e-14 | 0.8 | EXOC4 EXOC5 EXOC2 EXOC1 EXOC7 EXOC6 EXOC8 EXOC3 | NF1 copy number variation syndrome |
| GO:0061640 | 1.36154483941e-14 | 0.9 | EXOC4 EXOC5 EXOC2 EXOC7 EXOC6 EXOC1 EXOC3 EXOC8 EXOC6B | cytoskeleton-dependent cytokinesis |
| WP:WP4352 | 2.04680372183e-14 | 0.9 | EXOC4 EXOC5 EXOC2 EXOC7 EXOC6 EXOC1 EXOC3 EXOC8 EXOC6B | Ciliary landscape |
| GO:0000910 | 7.94295015178e-13 | 0.9 | EXOC4 EXOC5 EXOC2 EXOC7 EXOC6 EXOC1 EXOC3 EXOC8 EXOC6B | cytokinesis |
| GO:0051650 | 1.39857189452e-12 | 0.9 | EXOC4 EXOC5 EXOC2 EXOC7 EXOC6 EXOC1 EXOC3 EXOC8 EXOC6B | establishment of vesicle localization |
| GO:0051648 | 1.93197667521e-12 | 0.9 | EXOC4 EXOC5 EXOC2 EXOC7 EXOC6 EXOC1 EXOC3 EXOC8 EXOC6B | vesicle localization |
| GO:0005938 | 1.93197667521e-12 | 0.9 | EXOC4 EXOC5 EXOC2 EXOC7 EXOC6 EXOC1 EXOC3 EXOC8 EXOC6B | cell cortex |
| REAC:R-HSA-5617833 | 7.17001804119e-12 | 0.8 | EXOC4 EXOC5 EXOC2 EXOC1 EXOC7 EXOC6 EXOC8 EXOC3 | Cilium Assembly |
| GO:0006887 | 2.04312610407e-11 | 0.9 | EXOC4 EXOC5 EXOC2 EXOC7 EXOC6 EXOC1 EXOC3 EXOC8 EXOC6B | exocytosis |
| GO:0051301 | 3.16142465598e-11 | 0.9 | EXOC4 EXOC5 EXOC2 EXOC7 EXOC6 EXOC1 EXOC3 EXOC8 EXOC6B | cell division |
| GO:0006893 | 3.73388506956e-11 | 0.7 | EXOC5 EXOC4 EXOC2 EXOC1 EXOC6 EXOC8 EXOC6B | Golgi to plasma membrane transport |
| REAC:R-HSA-1852241 | 1.49438019097e-10 | 0.8 | EXOC4 EXOC5 EXOC2 EXOC1 EXOC7 EXOC6 EXOC8 EXOC3 | Organelle biogenesis and maintenance |
| GO:0051656 | 1.76288428966e-09 | 0.9 | EXOC4 EXOC5 EXOC2 EXOC7 EXOC6 EXOC1 EXOC3 EXOC8 EXOC6B | establishment of organelle localization |
| GO:0006892 | 2.31256615922e-09 | 0.7 | EXOC5 EXOC4 EXOC2 EXOC1 EXOC6 EXOC8 EXOC6B | post-Golgi vesicle-mediated transport |
| GO:0032940 | 1.44803962811e-08 | 0.9 | EXOC4 EXOC5 EXOC2 EXOC7 EXOC6 EXOC1 EXOC3 EXOC8 EXOC6B | secretion by cell |
| GO:0051640 | 1.62696879461e-08 | 0.9 | EXOC4 EXOC5 EXOC2 EXOC7 EXOC6 EXOC1 EXOC3 EXOC8 EXOC6B | organelle localization |
| CORUM:6169 | 1.68385473419e-08 | 0.3 | EXOC5 EXOC7 EXOC6 | Exocyst EXOC5-EXOC6-EXOC7 subcomplex |
| GO:0098876 | 2.0789256937e-08 | 0.7 | EXOC5 EXOC4 EXOC2 EXOC1 EXOC6 EXOC8 EXOC6B | vesicle-mediated transport to the plasma membrane |
| GO:0046903 | 3.35051064473e-08 | 0.9 | EXOC4 EXOC5 EXOC2 EXOC7 EXOC6 EXOC1 EXOC3 EXOC8 EXOC6B | secretion |
| GO:0140352 | 3.47165058468e-08 | 0.9 | EXOC4 EXOC5 EXOC2 EXOC7 EXOC6 EXOC1 EXOC3 EXOC8 EXOC6B | export from cell |
| REAC:R-HSA-199991 | 5.39749035374e-08 | 0.8 | EXOC4 EXOC5 EXOC2 EXOC1 EXOC7 EXOC6 EXOC8 EXOC3 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 8.32486844897e-08 | 0.8 | EXOC4 EXOC5 EXOC2 EXOC1 EXOC7 EXOC6 EXOC8 EXOC3 | Vesicle-mediated transport |
| GO:0061024 | 8.75659409748e-08 | 0.9 | EXOC4 EXOC5 EXOC2 EXOC7 EXOC6 EXOC1 EXOC3 EXOC8 EXOC6B | membrane organization |
| GO:1903047 | 1.46162698754e-07 | 0.9 | EXOC4 EXOC5 EXOC2 EXOC7 EXOC6 EXOC1 EXOC3 EXOC8 EXOC6B | mitotic cell cycle process |
| GO:0000278 | 8.08807727299e-07 | 0.9 | EXOC4 EXOC5 EXOC2 EXOC7 EXOC6 EXOC1 EXOC3 EXOC8 EXOC6B | mitotic cell cycle |
| GO:0048193 | 3.89038908753e-06 | 0.7 | EXOC5 EXOC4 EXOC2 EXOC1 EXOC6 EXOC8 EXOC6B | Golgi vesicle transport |
| GO:0022402 | 1.24477523995e-05 | 0.9 | EXOC4 EXOC5 EXOC2 EXOC7 EXOC6 EXOC1 EXOC3 EXOC8 EXOC6B | cell cycle process |
| CORUM:6168 | 3.07577115383e-05 | 0.2 | EXOC5 EXOC6 | Exocyst EXOC5-EXOC6 subcomplex |
| GO:0016192 | 3.45008274803e-05 | 0.9 | EXOC4 EXOC5 EXOC2 EXOC7 EXOC6 EXOC1 EXOC3 EXOC8 EXOC6B | vesicle-mediated transport |
| GO:0007049 | 0.000114963249686 | 0.9 | EXOC4 EXOC5 EXOC2 EXOC7 EXOC6 EXOC1 EXOC3 EXOC8 EXOC6B | cell cycle |
| GO:0051649 | 0.000279066091397 | 0.9 | EXOC4 EXOC5 EXOC2 EXOC7 EXOC6 EXOC1 EXOC3 EXOC8 EXOC6B | establishment of localization in cell |
| REAC:R-HSA-392499 | 0.000299670392981 | 0.8 | EXOC4 EXOC5 EXOC2 EXOC1 EXOC7 EXOC6 EXOC8 EXOC3 | Metabolism of proteins |
| GO:0051668 | 0.000438600863022 | 0.7 | EXOC5 EXOC4 EXOC2 EXOC1 EXOC6 EXOC8 EXOC6B | localization within membrane |
| KEGG:05132 | 0.000528418828391 | 0.4 | EXOC4 EXOC5 EXOC2 EXOC7 | Salmonella infection |
| WP:WP2290 | 0.00272734094269 | 0.2 | EXOC8 EXOC2 | RalA downstream regulated genes |
| GO:0051641 | 0.0345887146099 | 0.9 | EXOC4 EXOC5 EXOC2 EXOC7 EXOC6 EXOC1 EXOC3 EXOC8 EXOC6B | cellular localization |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| EXOC6B | EXOC8 | 1.0 | 0.46 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt Malo bioplex3_HCT116 fraction boldt_WMM | |
| EXOC7 | EXOC8 | 1.0 | 0.878 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt Malo bioplex3_HCT116 fraction boldt_WMM |
| EXOC8 | EXOC6 | 1.0 | 0.218 |
structurally_consistent (Q9UPT5)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt Malo bioplex3_HCT116 fraction boldt_WMM |
| EXOC7 | EXOC6 | 1.0 | 0.102 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt Malo bioplex3_HCT116 fraction boldt_WMM |
| EXOC1 | EXOC3 | 1.0 | 0.82 |
mutually_exclusive (Q96KP1)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt Malo bioplex3_HCT116 fraction boldt_WMM |
| EXOC5 | EXOC6 | 1.0 | 0.214 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt Malo bioplex3_HCT116 fraction boldt_WMM | |
| EXOC8 | EXOC5 | 1.0 | 0.736 |
structurally_consistent (Q96A65)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt Malo bioplex3_HCT116 fraction boldt_WMM |
| EXOC2 | EXOC3 | 1.0 | 0.956 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt Malo bioplex3_HCT116 fraction boldt_WMM treiber_WMM |
| EXOC4 | EXOC3 | 1.0 | 0.45 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM | |
| EXOC6B | EXOC5 | 1.0 | 0.268 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt Malo fraction boldt_WMM |
| EXOC1 | EXOC2 | 1.0 | 0.834 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt Malo fraction boldt_WMM |
| EXOC7 | EXOC3 | 1.0 | 0.486 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM | |
| EXOC1 | EXOC4 | 1.0 | 0.73 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt Malo fraction boldt_WMM | |
| EXOC3 | EXOC6 | 1.0 | 0.154 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM | |
| EXOC5 | EXOC3 | 1.0 | 0.608 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM | |
| EXOC6B | EXOC7 | 1.0 | 0.48 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt Malo fraction boldt_WMM | |
| EXOC1 | EXOC6 | 1.0 | 0.176 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM | |
| EXOC2 | EXOC8 | 1.0 | 0.512 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM | |
| EXOC1 | EXOC8 | 1.0 | 0.606 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM | |
| EXOC4 | EXOC6 | 1.0 | 0.178 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 fraction boldt_WMM | |
| EXOC6B | EXOC3 | 1.0 | 0.392 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM | |
| EXOC2 | EXOC6 | 1.0 | 0.09 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM | |
| EXOC8 | EXOC4 | 0.999 | 0.374 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM |
| EXOC1 | EXOC7 | 0.999 | 0.57 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt fraction boldt_WMM | |
| EXOC1 | EXOC5 | 0.999 | 0.782 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt fraction boldt_WMM | |
| EXOC6B | EXOC4 | 0.999 | 0.254 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt fraction boldt_WMM | |
| EXOC7 | EXOC5 | 0.999 | 0.802 | bioplex_WMM bioplex3_WMM boldt Malo fraction boldt_WMM | |
| EXOC6B | EXOC2 | 0.999 | 0.362 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt fraction boldt_WMM | |
| EXOC8 | EXOC3 | 0.999 | 0.786 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM | |
| EXOC6B | EXOC6 | 0.998 | 0.016 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| EXOC6B | EXOC1 | 0.998 | 0.374 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt fraction boldt_WMM | |
| EXOC2 | EXOC5 | 0.998 | 0.788 | bioplex_WMM bioplex3_WMM boldt fraction boldt_WMM | |
| EXOC2 | EXOC4 | 0.998 | 0.818 | bioplex_WMM bioplex3_WMM boldt youn_WMM Malo fraction boldt_WMM treiber_WMM | |
| EXOC7 | EXOC4 | 0.997 | 0.232 | bioplex_WMM bioplex3_WMM boldt fraction boldt_WMM | |
| EXOC2 | EXOC7 | 0.996 | 0.4 | bioplex_WMM bioplex3_WMM boldt fraction boldt_WMM | |
| EXOC4 | EXOC5 | 0.991 | 0.474 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| KRT86 | EXOC4 | 0.973 | 0.056 | bioplex3_HEK293 bioplex () bioplex3_HCT116 boldt_WMM | |
| EXOC1 | KRT86 | 0.027 | 0.054 | WMM_only boldt_WMM | |
| KRT86 | EXOC3 | 0.009 | 0.012 | WMM_only boldt_WMM | |
| EXOC8 | KRT86 | 0.009 | 0.024 | WMM_only boldt_WMM | |
| EXOC2 | KRT86 | 0.009 | 0.024 | WMM_only boldt_WMM | |
| KRT86 | EXOC5 | 0.009 | 0.044 | WMM_only boldt_WMM | |
| EXOC7 | KRT86 | 0.009 | 0.02 | WMM_only boldt_WMM | |
| EXOC6B | KRT86 | 0.009 | 0.016 | WMM_only boldt_WMM | |
| KRT86 | EXOC6 | 0.009 | 0.05 | WMM_only boldt_WMM |
Related Complexes