hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04057.1
Confidence: Extremely High  
ProteinsGenename | Protein Name | Uniprot Annotation Score | Links |
---|---|---|---|
TBP | TATA-box-binding protein (TATA sequence-binding protein) (TATA-binding factor) (TATA-box factor) (Transcription initiation factor TFIID TBP subunit) | 5 | UniProt   NCBI |
GTF2A1 | Transcription initiation factor IIA subunit 1 (General transcription factor IIA subunit 1) (TFIIAL) (Transcription initiation factor TFIIA 42 kDa subunit) (TFIIA-42) [Cleaved into: Transcription initiation factor IIA alpha chain (TFIIA p35 subunit); Transcription initiation factor IIA beta chain (TFIIA p19 subunit)] | 5 | UniProt   NCBI |
CUEDC2 | CUE domain-containing protein 2 | 5 | UniProt   NCBI |
TBPL1 | TATA box-binding protein-like 1 (TBP-like 1) (21 kDa TBP-like protein) (Second TBP of unique DNA protein) (STUD) (TATA box-binding protein-related factor 2) (TBP-related factor 2) (TBP-like factor) (TBP-related protein) | 5 | UniProt   NCBI |
GTF2A2 | Transcription initiation factor IIA subunit 2 (General transcription factor IIA subunit 2) (TFIIA p12 subunit) (TFIIA-12) (TFIIAS) (Transcription initiation factor IIA gamma chain) (TFIIA-gamma) | 5 | UniProt   NCBI |
Enrichments
Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
---|---|---|---|---|
  KEGG:03022 | 1.29091351664e-08 | 0.8 | GTF2A2 TBP TBPL1 GTF2A1 | Basal transcription factors |
  GO:0005672 | 9.61200410764e-07 | 0.6 | TBP GTF2A2 GTF2A1 | transcription factor TFIIA complex |
  CORUM:492 | 1.27349153941e-06 | 0.6 | TBP GTF2A2 GTF2A1 | DA complex |
  CORUM:493 | 1.56721321046e-06 | 0.6 | TBP GTF2A2 GTF2A1 | DAB complex |
  KEGG:05203 | 6.10505956244e-06 | 0.8 | GTF2A2 TBP TBPL1 GTF2A1 | Viral carcinogenesis |
  GO:0016251 | 8.67338862712e-06 | 0.8 | GTF2A2 TBP TBPL1 GTF2A1 | RNA polymerase II general transcription initiation factor activity |
  CORUM:490 | 1.36501667663e-05 | 0.4 | GTF2A1 GTF2A2 | TFIIA complex |
  CORUM:489 | 1.36501667663e-05 | 0.4 | GTF2A1 GTF2A2 | TFIIA complex |
  GO:0140223 | 2.55378856908e-05 | 0.8 | GTF2A2 TBP TBPL1 GTF2A1 | general transcription initiation factor activity |
  CORUM:1221 | 4.09448956317e-05 | 0.4 | GTF2A1 GTF2A2 | TFIIA-TRF2 complex |
  REAC:R-HSA-73776 | 4.40931593476e-05 | 0.6 | TBP GTF2A2 GTF2A1 | RNA Polymerase II Promoter Escape |
  REAC:R-HSA-75953 | 4.40931593476e-05 | 0.6 | TBP GTF2A2 GTF2A1 | RNA Polymerase II Transcription Initiation |
  REAC:R-HSA-76042 | 4.40931593476e-05 | 0.6 | TBP GTF2A2 GTF2A1 | RNA Polymerase II Transcription Initiation And Promoter Clearance |
  REAC:R-HSA-73779 | 4.40931593476e-05 | 0.6 | TBP GTF2A2 GTF2A1 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
  REAC:R-HSA-167162 | 4.40931593476e-05 | 0.6 | TBP GTF2A2 GTF2A1 | RNA Polymerase II HIV Promoter Escape |
  REAC:R-HSA-167161 | 4.40931593476e-05 | 0.6 | TBP GTF2A2 GTF2A1 | HIV Transcription Initiation |
  REAC:R-HSA-167172 | 0.00015535926553 | 0.6 | TBP GTF2A2 GTF2A1 | Transcription of the HIV genome |
  REAC:R-HSA-6807505 | 0.00018480745401 | 0.6 | TBP GTF2A2 GTF2A1 | RNA polymerase II transcribes snRNA genes |
  REAC:R-HSA-674695 | 0.000244866764891 | 0.6 | TBP GTF2A2 GTF2A1 | RNA Polymerase II Pre-transcription Events |
  GO:0000979 | 0.000349481973524 | 0.6 | TBP TBPL1 GTF2A1 | RNA polymerase II core promoter sequence-specific DNA binding |
  REAC:R-HSA-9018519 | 0.00102719141084 | 0.6 | TBP GTF2A2 GTF2A1 | Estrogen-dependent gene expression |
  GO:0001091 | 0.00109385703544 | 0.6 | TBP GTF2A2 GTF2A1 | RNA polymerase II general transcription initiation factor binding |
  REAC:R-HSA-162599 | 0.00110198471879 | 0.6 | TBP GTF2A2 GTF2A1 | Late Phase of HIV Life Cycle |
  REAC:R-HSA-162587 | 0.00143724099843 | 0.6 | TBP GTF2A2 GTF2A1 | HIV Life Cycle |
  GO:0006352 | 0.0022427823715 | 0.8 | GTF2A2 TBP TBPL1 GTF2A1 | DNA-templated transcription initiation |
  REAC:R-HSA-8939211 | 0.00317982187903 | 0.6 | TBP GTF2A2 GTF2A1 | ESR-mediated signaling |
  GO:0005669 | 0.00430818612204 | 0.6 | TBP GTF2A2 GTF2A1 | transcription factor TFIID complex |
  WP:WP405 | 0.00456408083355 | 0.4 | TBP GTF2A2 | Eukaryotic transcription initiation |
  GO:0001046 | 0.00475337188383 | 0.6 | TBP TBPL1 GTF2A1 | core promoter sequence-specific DNA binding |
  REAC:R-HSA-162906 | 0.00541502775671 | 0.6 | TBP GTF2A2 GTF2A1 | HIV Infection |
  REAC:R-HSA-9006931 | 0.00755035935577 | 0.6 | TBP GTF2A2 GTF2A1 | Signaling by Nuclear Receptors |
  GO:0140296 | 0.0094606249379 | 0.6 | TBP GTF2A2 GTF2A1 | general transcription initiation factor binding |
  GO:0051123 | 0.0211358171848 | 0.6 | TBP GTF2A2 GTF2A1 | RNA polymerase II preinitiation complex assembly |
  GO:0001099 | 0.0211358171848 | 0.6 | TBP GTF2A2 GTF2A1 | basal RNA polymerase II transcription machinery binding |
  GO:0001098 | 0.0211358171848 | 0.6 | TBP GTF2A2 GTF2A1 | basal transcription machinery binding |
  GO:0070897 | 0.0237169649094 | 0.6 | TBP GTF2A2 GTF2A1 | transcription preinitiation complex assembly |
  GO:0060261 | 0.0237169649094 | 0.6 | TBP GTF2A2 GTF2A1 | positive regulation of transcription initiation by RNA polymerase II |
  GO:2000144 | 0.0327001087246 | 0.6 | TBP GTF2A2 GTF2A1 | positive regulation of DNA-templated transcription initiation |
  GO:0060260 | 0.0343879535233 | 0.6 | TBP GTF2A2 GTF2A1 | regulation of transcription initiation by RNA polymerase II |
  KEGG:05017 | 0.0346393491085 | 0.4 | TBP TBPL1 | Spinocerebellar ataxia |
  GO:2000142 | 0.0457443058639 | 0.6 | TBP GTF2A2 GTF2A1 | regulation of DNA-templated transcription initiation |
  GO:0016591 | 0.0478506537833 | 0.6 | TBP GTF2A2 GTF2A1 | RNA polymerase II, holoenzyme |
  CORUM:721 | 0.0498708842806 | 0.2 | TBP | PU.1-TBP complex |
Edges
Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
---|---|---|---|---|
 GTF2A1 |  GTF2A2 | 1.0 | 0.224           | bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     youn_WMM     bioplex3_HCT116     gupta_WMM     fraction     |
 GTF2A1 |  TBPL1 | 1.0 | 0.12           | bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     youn_WMM     bioplex3_HCT116     gupta_WMM     |
 TBP |  GTF2A1 | 0.999 | 0.094           | bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116     gupta_WMM     |
 TBPL1 |  GTF2A2 | 0.997 | 0.09           | bioplex3_HEK293     bioplex_WMM     bioplex3_WMM     youn_WMM     bioplex3_HCT116     gupta_WMM     WMM_only     |
 TBP |  GTF2A2 | 0.995 | 0.204           | bioplex3_HEK293     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116     gupta_WMM     WMM_only     |
 CUEDC2 |  GTF2A2 | 0.987 | 0.052           | bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     youn_WMM     |
 TBP |  TBPL1 | 0.881 | 0.124           | bioplex_WMM     bioplex3_WMM     gupta_WMM     WMM_only     |
 TBP |  CUEDC2 | 0.871 | 0.062           | bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     |
 GTF2A1 |  CUEDC2 | 0.622 | 0.118           | bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     youn_WMM     gupta_WMM     |
 CUEDC2 |  TBPL1 | 0.037 | 0.078           | bioplex3_WMM     youn_WMM     gupta_WMM     WMM_only     |
Related Complexes