hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_04060.1
Complex Portal: CPX-21180
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PDE4D | 3',5'-cyclic-AMP phosphodiesterase 4D (EC 3.1.4.53) (DPDE3) (PDE43) (cAMP-specific phosphodiesterase 4D) | 5 | UniProt NCBI |
| PDE4B | 3',5'-cyclic-AMP phosphodiesterase 4B (EC 3.1.4.53) (DPDE4) (PDE32) (cAMP-specific phosphodiesterase 4B) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP5294 | 7.2783930122e-05 | 1.0 | PDE4B PDE4D | Sildenafil treatment |
| WP:WP4222 | 0.000299222823835 | 1.0 | PDE4B PDE4D | Phosphodiesterases in neuronal function |
| KEGG:05032 | 0.00037033376401 | 1.0 | PDE4B PDE4D | Morphine addiction |
| GO:1901898 | 0.000468200720083 | 1.0 | PDE4B PDE4D | negative regulation of relaxation of cardiac muscle |
| KEGG:04928 | 0.000553224670293 | 1.0 | PDE4B PDE4D | Parathyroid hormone synthesis, secretion and action |
| KEGG:00230 | 0.000772693757832 | 1.0 | PDE4B PDE4D | Purine metabolism |
| WP:WP35 | 0.00127818796583 | 1.0 | PDE4B PDE4D | G protein signaling pathways |
| KEGG:04024 | 0.00201635192055 | 1.0 | PDE4B PDE4D | cAMP signaling pathway |
| WP:WP289 | 0.00362429921046 | 1.0 | PDE4B PDE4D | Myometrial relaxation and contraction pathways |
| GO:1901078 | 0.00468200720083 | 1.0 | PDE4B PDE4D | negative regulation of relaxation of muscle |
| GO:1901897 | 0.00468200720083 | 1.0 | PDE4B PDE4D | regulation of relaxation of cardiac muscle |
| GO:0071871 | 0.0131096201623 | 1.0 | PDE4B PDE4D | response to epinephrine |
| GO:0071872 | 0.0131096201623 | 1.0 | PDE4B PDE4D | cellular response to epinephrine stimulus |
| GO:1901077 | 0.016855225923 | 1.0 | PDE4B PDE4D | regulation of relaxation of muscle |
| GO:0030552 | 0.0257510396046 | 1.0 | PDE4B PDE4D | cAMP binding |
| GO:0071875 | 0.0257510396046 | 1.0 | PDE4B PDE4D | adrenergic receptor signaling pathway |
| GO:0004115 | 0.0309012475255 | 1.0 | PDE4B PDE4D | 3',5'-cyclic-AMP phosphodiesterase activity |
| GO:1902514 | 0.0365196561665 | 1.0 | PDE4B PDE4D | regulation of calcium ion transmembrane transport via high voltage-gated calcium channel |
| GO:0061577 | 0.0426062655276 | 1.0 | PDE4B PDE4D | calcium ion transmembrane transport via high voltage-gated calcium channel |
| GO:0055119 | 0.0491610756088 | 1.0 | PDE4B PDE4D | relaxation of cardiac muscle |
| CORUM:518 | 0.0499419797295 | 0.5 | PDE4D | AKAP250-PKA-PDE4D complex |
| CORUM:6046 | 0.0499419797295 | 0.5 | PDE4B | PDE4B-DISC1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PDE4D | PDE4B | 1.0 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
Related Complexes