hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04078.1
Complex Portal: CPX-21331
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CDK12 | Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) | 5 | UniProt NCBI |
| CCNK | Cyclin-K | 5 | UniProt NCBI |
| GTF2F2 | General transcription factor IIF subunit 2 (General transcription factor IIF 30 kDa subunit) (Transcription initiation factor IIF subunit beta) (TFIIF-beta) (Transcription initiation factor RAP30) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0002944 | 0.000468200720083 | 1.0 | CDK12 CCNK | cyclin K-CDK12 complex |
| REAC:R-HSA-6796648 | 0.0031270340064 | 1.0 | CDK12 CCNK | TP53 Regulates Transcription of DNA Repair Genes |
| GO:0008024 | 0.0131096201623 | 1.0 | CDK12 CCNK | cyclin/CDK positive transcription elongation factor complex |
| GO:0008353 | 0.016855225923 | 1.0 | CDK12 CCNK | RNA polymerase II CTD heptapeptide repeat kinase activity |
| CORUM:1083 | 0.0499419797295 | 0.5 | CCNK | P-TEFb.4 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CDK12 | CCNK | 0.996 | 0.59 | hein_WMM bioplex_WMM Guru bioplex3_WMM youn_WMM gupta_WMM fraction | |
| CDK12 | GTF2F2 | 0.961 | 0.102 | hein_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| CCNK | GTF2F2 | 0.067 | 0.45 | bioplex3_WMM youn_WMM gupta_WMM WMM_only |
Related Complexes