hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_04081.1
Complex Portal: CPX-15467
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GRB10 | Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR) | 5 | UniProt NCBI |
| WDR24 | GATOR2 complex protein WDR24 (EC 2.3.2.27) (WD repeat-containing protein 24) | 5 | UniProt NCBI |
| WDR59 | GATOR2 complex protein WDR59 (WD repeat-containing protein 59) | 5 | UniProt NCBI |
| MIOS | GATOR2 complex protein MIOS (Missing oocyte meiosis regulator homolog) | 5 | UniProt NCBI |
| CASTOR2 | Cytosolic arginine sensor for mTORC1 subunit 2 (Cellular arginine sensor for mTORC1 protein 2) (GATS-like protein 2) | 5 | UniProt NCBI |
| NRF1 | Nuclear respiratory factor 1 (NRF-1) (Alpha palindromic-binding protein) (Alpha-pal) | 5 | UniProt NCBI |
| SEH1L | Nucleoporin SEH1 (GATOR2 complex protein SEH1) (Nup107-160 subcomplex subunit SEH1) (SEC13-like protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6216 | 9.61159511016e-12 | 0.571428571429 | SEH1L WDR59 WDR24 MIOS | GATOR2 complex |
| GO:0061700 | 2.38147473756e-11 | 0.714285714286 | SEH1L WDR59 CASTOR2 WDR24 MIOS | GATOR2 complex |
| CORUM:6753 | 1.34496026232e-10 | 0.571428571429 | SEH1L WDR59 WDR24 MIOS | SOG complex |
| CORUM:6217 | 1.34496026232e-10 | 0.571428571429 | SEH1L WDR59 WDR24 MIOS | GATOR complex |
| GO:0035859 | 2.43139621751e-10 | 0.714285714286 | SEH1L WDR59 CASTOR2 WDR24 MIOS | Seh1-associated complex |
| KEGG:04150 | 3.52955847977e-10 | 0.857142857143 | CASTOR2 WDR24 MIOS SEH1L GRB10 WDR59 | mTOR signaling pathway |
| REAC:R-HSA-9639288 | 2.09173590301e-09 | 0.714285714286 | SEH1L WDR59 CASTOR2 WDR24 MIOS | Amino acids regulate mTORC1 |
| GO:1904262 | 1.6017646366e-07 | 0.714285714286 | SEH1L WDR59 CASTOR2 WDR24 MIOS | negative regulation of TORC1 signaling |
| REAC:R-HSA-9711097 | 4.71302084746e-07 | 0.714285714286 | SEH1L WDR59 CASTOR2 WDR24 MIOS | Cellular response to starvation |
| GO:0032007 | 9.40846017629e-07 | 0.714285714286 | SEH1L WDR59 CASTOR2 WDR24 MIOS | negative regulation of TOR signaling |
| GO:1903432 | 6.14603730372e-06 | 0.714285714286 | SEH1L WDR59 CASTOR2 WDR24 MIOS | regulation of TORC1 signaling |
| GO:0038202 | 7.77374413874e-06 | 0.714285714286 | SEH1L WDR59 CASTOR2 WDR24 MIOS | TORC1 signaling |
| REAC:R-HSA-2262752 | 1.8673790515e-05 | 0.857142857143 | CASTOR2 WDR24 MIOS SEH1L GRB10 WDR59 | Cellular responses to stress |
| REAC:R-HSA-8953897 | 1.97806453975e-05 | 0.857142857143 | CASTOR2 WDR24 MIOS SEH1L GRB10 WDR59 | Cellular responses to stimuli |
| GO:0032006 | 4.1998164774e-05 | 0.714285714286 | SEH1L WDR59 CASTOR2 WDR24 MIOS | regulation of TOR signaling |
| GO:0031929 | 7.21864524745e-05 | 0.714285714286 | SEH1L WDR59 CASTOR2 WDR24 MIOS | TOR signaling |
| GO:0034198 | 0.000112926960567 | 0.571428571429 | SEH1L WDR59 WDR24 MIOS | cellular response to amino acid starvation |
| GO:1990928 | 0.000136293772339 | 0.571428571429 | SEH1L WDR59 WDR24 MIOS | response to amino acid starvation |
| GO:1904263 | 0.000210494508038 | 0.571428571429 | SEH1L WDR59 WDR24 MIOS | positive regulation of TORC1 signaling |
| GO:0032008 | 0.000617288463902 | 0.571428571429 | SEH1L WDR59 WDR24 MIOS | positive regulation of TOR signaling |
| GO:0009267 | 0.00717572690708 | 0.571428571429 | SEH1L WDR59 WDR24 MIOS | cellular response to starvation |
| GO:0042594 | 0.0122857546787 | 0.571428571429 | SEH1L WDR59 WDR24 MIOS | response to starvation |
| GO:1902532 | 0.0134243874038 | 0.714285714286 | SEH1L WDR59 CASTOR2 WDR24 MIOS | negative regulation of intracellular signal transduction |
| GO:0009968 | 0.0158909499494 | 0.857142857143 | CASTOR2 WDR24 MIOS SEH1L GRB10 WDR59 | negative regulation of signal transduction |
| GO:0010648 | 0.0192668399957 | 0.857142857143 | CASTOR2 WDR24 MIOS SEH1L GRB10 WDR59 | negative regulation of cell communication |
| GO:0023057 | 0.0200347036461 | 0.857142857143 | CASTOR2 WDR24 MIOS SEH1L GRB10 WDR59 | negative regulation of signaling |
| GO:0031669 | 0.02419782013 | 0.571428571429 | SEH1L WDR59 WDR24 MIOS | cellular response to nutrient levels |
| GO:0031668 | 0.0300947153732 | 0.571428571429 | SEH1L WDR59 WDR24 MIOS | cellular response to extracellular stimulus |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| WDR59 | NRF1 | 0.996 | 0.162 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| WDR59 | SEH1L | 0.996 | 0.174 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () boldt_WMM |
| MIOS | SEH1L | 0.994 | 0.184 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM hein () boldt_WMM |
| WDR24 | MIOS | 0.994 | 0.108 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| GRB10 | WDR59 | 0.993 | 0.078 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MIOS | CASTOR2 | 0.993 | 0.064 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| WDR24 | WDR59 | 0.993 | 0.146 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM WMM_only boldt_WMM |
| WDR59 | MIOS | 0.987 | 0.298 |
structurally_consistent (Q96S15)
|
hein_WMM bioplex_WMM bioplex3_WMM WMM_only boldt_WMM |
| CASTOR2 | SEH1L | 0.982 | 0.028 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| WDR24 | CASTOR2 | 0.98 | 0.084 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| WDR59 | CASTOR2 | 0.977 | 0.034 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| WDR24 | SEH1L | 0.956 | 0.11 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM hein () boldt_WMM |
| GRB10 | NRF1 | 0.89 | 0.064 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes