hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04090.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GATC | Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial (Glu-AdT subunit C) (EC 6.3.5.-) (Protein 15E1.2) | 5 | UniProt NCBI |
| QRSL1 | Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial (Glu-AdT subunit A) (EC 6.3.5.7) (Glutaminyl-tRNA synthase-like protein 1) | 5 | UniProt NCBI |
| COQ6 | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial (EC 1.14.13.-) (Coenzyme Q10 monooxygenase 6) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6959 | 1.02521027753e-05 | 0.666666666667 | GATC QRSL1 | GATB-GATC-QRSL1 complex |
| KEGG:00970 | 0.000688034410789 | 0.666666666667 | GATC QRSL1 | Aminoacyl-tRNA biosynthesis |
| HP:0008163 | 0.00410807097178 | 0.666666666667 | GATC QRSL1 | Decreased circulating cortisol level |
| GO:0050567 | 0.00421361424067 | 0.666666666667 | GATC QRSL1 | glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity |
| GO:0030956 | 0.00421361424067 | 0.666666666667 | GATC QRSL1 | glutamyl-tRNA(Gln) amidotransferase complex |
| GO:0070681 | 0.00421361424067 | 0.666666666667 | GATC QRSL1 | glutaminyl-tRNAGln biosynthesis via transamidation |
| HP:0011924 | 0.00888120343534 | 0.666666666667 | GATC QRSL1 | Decreased activity of mitochondrial complex III |
| HP:0008207 | 0.0130706759587 | 0.666666666667 | GATC QRSL1 | Primary adrenal insufficiency |
| HP:0011731 | 0.0148492820647 | 0.666666666667 | GATC QRSL1 | Abnormality of circulating cortisol level |
| HP:0012111 | 0.0154672949612 | 0.666666666667 | GATC QRSL1 | Abnormality of circulating glucocorticoid level |
| HP:0008347 | 0.0187458629677 | 0.666666666667 | GATC QRSL1 | Decreased activity of mitochondrial complex IV |
| KEGG:01100 | 0.0189521995452 | 1.0 | COQ6 GATC QRSL1 | Metabolic pathways |
| HP:0001790 | 0.0215948176879 | 0.666666666667 | GATC QRSL1 | Nonimmune hydrops fetalis |
| HP:0000846 | 0.0359423574679 | 0.666666666667 | GATC QRSL1 | Adrenal insufficiency |
| HP:0003811 | 0.0418708017344 | 0.666666666667 | GATC QRSL1 | Neonatal death |
| HP:0011923 | 0.0493566712329 | 0.666666666667 | GATC QRSL1 | Decreased activity of mitochondrial complex I |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| GATC | QRSL1 | 1.0 | 0.68 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| QRSL1 | COQ6 | 0.99 | 0.014 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| GATC | COQ6 | 0.22 | 0.044 | bioplex3_WMM WMM_only |
Related Complexes