hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_04092.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MAPK8 | Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (JNK-46) (Stress-activated protein kinase 1c) (SAPK1c) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) | 5 | UniProt NCBI |
| DUSP8 | Dual specificity protein phosphatase 8 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH-5) | 5 | UniProt NCBI |
| STK11IP | Serine/threonine-protein kinase 11-interacting protein (LKB1-interacting protein 1) | 5 | UniProt NCBI |
| MAPK9 | Mitogen-activated protein kinase 9 (MAP kinase 9) (MAPK 9) (EC 2.7.11.24) (JNK-55) (Stress-activated protein kinase 1a) (SAPK1a) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP3874 | 0.000267833349503 | 0.5 | MAPK8 MAPK9 | Canonical and non canonical TGF B signaling |
| REAC:R-HSA-450341 | 0.000461028962628 | 0.5 | MAPK8 MAPK9 | Activation of the AP-1 family of transcription factors |
| WP:WP382 | 0.000461288756706 | 0.75 | MAPK8 DUSP8 MAPK9 | MAPK signaling pathway |
| WP:WP3869 | 0.000764539714508 | 0.5 | MAPK8 MAPK9 | Cannabinoid receptor signaling |
| KEGG:04010 | 0.000800866642312 | 0.75 | MAPK8 DUSP8 MAPK9 | MAPK signaling pathway |
| WP:WP2643 | 0.000894348084449 | 0.5 | MAPK8 MAPK9 | Nanoparticle mediated activation of receptor signaling |
| WP:WP5406 | 0.00096305612306 | 0.5 | MAPK8 MAPK9 | 13q12 12 copy number variation |
| KEGG:04215 | 0.00101582950709 | 0.5 | MAPK8 MAPK9 | Apoptosis - multiple species |
| WP:WP4877 | 0.00110807642161 | 0.5 | MAPK8 MAPK9 | Host pathogen interaction of human coronaviruses MAPK signaling |
| WP:WP4331 | 0.00126323103486 | 0.5 | MAPK8 MAPK9 | Neovascularisation processes |
| REAC:R-HSA-450321 | 0.0013924419067 | 0.5 | MAPK8 MAPK9 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| WP:WP4150 | 0.00142851438729 | 0.5 | MAPK8 MAPK9 | Wnt signaling in kidney disease |
| WP:WP2203 | 0.00142851438729 | 0.5 | MAPK8 MAPK9 | Thymic stromal lymphopoietin TSLP signaling pathway |
| WP:WP2036 | 0.00160392090455 | 0.5 | MAPK8 MAPK9 | TNF related weak inducer of apoptosis TWEAK signaling pathway |
| WP:WP5347 | 0.00188599942343 | 0.5 | MAPK8 MAPK9 | IL 26 signaling pathways |
| WP:WP4534 | 0.00198508114189 | 0.5 | MAPK8 MAPK9 | Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms |
| KEGG:04930 | 0.00204942716049 | 0.5 | MAPK8 MAPK9 | Type II diabetes mellitus |
| WP:WP4566 | 0.0020866894725 | 0.5 | MAPK8 MAPK9 | Translation inhibitors in chronically activated PDGFRA cells |
| REAC:R-HSA-2871796 | 0.00214930898727 | 0.5 | MAPK8 MAPK9 | FCERI mediated MAPK activation |
| WP:WP2637 | 0.0022974831852 | 0.5 | MAPK8 MAPK9 | Interleukin 1 IL 1 structural pathway |
| WP:WP363 | 0.00251837499235 | 0.5 | MAPK8 MAPK9 | Wnt signaling pathway |
| WP:WP2018 | 0.00263260594128 | 0.5 | MAPK8 MAPK9 | RANKL RANK signaling pathway |
| WP:WP195 | 0.00286863445038 | 0.5 | MAPK8 MAPK9 | IL 1 signaling pathway |
| KEGG:04664 | 0.0034402616107 | 0.5 | MAPK8 MAPK9 | Fc epsilon RI signaling pathway |
| WP:WP2374 | 0.0035028118218 | 0.5 | MAPK8 MAPK9 | Oncostatin M signaling pathway |
| WP:WP3865 | 0.00363720277712 | 0.5 | MAPK8 MAPK9 | Novel intracellular components of RIG I like receptor pathway |
| KEGG:05133 | 0.00426927356048 | 0.5 | MAPK8 MAPK9 | Pertussis |
| WP:WP5158 | 0.00434689671613 | 0.5 | MAPK8 MAPK9 | Urotensin II mediated signaling pathway |
| REAC:R-HSA-450282 | 0.00444848198459 | 0.5 | MAPK8 MAPK9 | MAPK targets/ Nuclear events mediated by MAP kinases |
| WP:WP2324 | 0.00449637847065 | 0.5 | MAPK8 MAPK9 | AGE RAGE pathway |
| WP:WP4538 | 0.00449637847065 | 0.5 | MAPK8 MAPK9 | Regulatory circuits of the STAT3 signaling pathway |
| WP:WP69 | 0.00464837292584 | 0.5 | MAPK8 MAPK9 | T cell receptor signaling pathway |
| KEGG:04917 | 0.00471711368352 | 0.5 | MAPK8 MAPK9 | Prolactin signaling pathway |
| KEGG:05120 | 0.00487132756685 | 0.5 | MAPK8 MAPK9 | Epithelial cell signaling in Helicobacter pylori infection |
| KEGG:04920 | 0.00487132756685 | 0.5 | MAPK8 MAPK9 | Adipocytokine signaling pathway |
| WP:WP3303 | 0.00495989715897 | 0.5 | MAPK8 MAPK9 | RAC1 PAK1 p38 MMP2 pathway |
| WP:WP4341 | 0.00495989715897 | 0.5 | MAPK8 MAPK9 | Non genomic actions of 1 25 dihydroxyvitamin D3 |
| KEGG:04622 | 0.00518715200321 | 0.5 | MAPK8 MAPK9 | RIG-I-like receptor signaling pathway |
| WP:WP5094 | 0.00561306746582 | 0.5 | MAPK8 MAPK9 | Orexin receptor pathway |
| WP:WP4216 | 0.00561306746582 | 0.5 | MAPK8 MAPK9 | Chromosomal and microsatellite instability in colorectal cancer |
| WP:WP2037 | 0.00561306746582 | 0.5 | MAPK8 MAPK9 | Prolactin signaling pathway |
| KEGG:04912 | 0.0056793701001 | 0.5 | MAPK8 MAPK9 | GnRH signaling pathway |
| KEGG:04750 | 0.00584836845565 | 0.5 | MAPK8 MAPK9 | Inflammatory mediator regulation of TRP channels |
| KEGG:05212 | 0.00637013094617 | 0.5 | MAPK8 MAPK9 | Pancreatic cancer |
| KEGG:04658 | 0.00673027197618 | 0.5 | MAPK8 MAPK9 | Th1 and Th2 cell differentiation |
| WP:WP5353 | 0.00685264055756 | 0.5 | MAPK8 MAPK9 | A network map of Macrophage stimulating protein MSP signaling |
| WP:WP2355 | 0.00703973989842 | 0.5 | MAPK8 MAPK9 | Corticotropin releasing hormone signaling pathway |
| KEGG:04012 | 0.00710024614077 | 0.5 | MAPK8 MAPK9 | ErbB signaling pathway |
| WP:WP23 | 0.00722934152515 | 0.5 | MAPK8 MAPK9 | B cell receptor signaling pathway |
| KEGG:04657 | 0.00728891894502 | 0.5 | MAPK8 MAPK9 | IL-17 signaling pathway |
| KEGG:05210 | 0.00748004798883 | 0.5 | MAPK8 MAPK9 | Colorectal cancer |
| WP:WP4263 | 0.00821485966847 | 0.5 | MAPK8 MAPK9 | Pancreatic adenocarcinoma pathway |
| WP:WP673 | 0.00821485966847 | 0.5 | MAPK8 MAPK9 | ErbB signaling pathway |
| KEGG:01522 | 0.00826911293642 | 0.5 | MAPK8 MAPK9 | Endocrine resistance |
| KEGG:04914 | 0.00826911293642 | 0.5 | MAPK8 MAPK9 | Progesterone-mediated oocyte maturation |
| GO:0004705 | 0.00842684400117 | 0.5 | MAPK8 MAPK9 | JUN kinase activity |
| KEGG:05231 | 0.00847251296121 | 0.5 | MAPK8 MAPK9 | Choline metabolism in cancer |
| WP:WP75 | 0.00862655865142 | 0.5 | MAPK8 MAPK9 | Toll like receptor signaling pathway |
| WP:WP231 | 0.00883615359641 | 0.5 | MAPK8 MAPK9 | TNF alpha signaling pathway |
| KEGG:04625 | 0.00888666878999 | 0.5 | MAPK8 MAPK9 | C-type lectin receptor signaling pathway |
| KEGG:04620 | 0.00931062778609 | 0.5 | MAPK8 MAPK9 | Toll-like receptor signaling pathway |
| KEGG:04933 | 0.00931062778609 | 0.5 | MAPK8 MAPK9 | AGE-RAGE signaling pathway in diabetic complications |
| KEGG:05142 | 0.0095262817703 | 0.5 | MAPK8 MAPK9 | Chagas disease |
| KEGG:04659 | 0.00996493530849 | 0.5 | MAPK8 MAPK9 | Th17 cell differentiation |
| KEGG:05145 | 0.0101879335017 | 0.5 | MAPK8 MAPK9 | Toxoplasmosis |
| KEGG:04668 | 0.011104386562 | 0.5 | MAPK8 MAPK9 | TNF signaling pathway |
| WP:WP5380 | 0.011545786253 | 0.5 | MAPK8 MAPK9 | 5q35 copy number variation |
| KEGG:04137 | 0.0118173906169 | 0.5 | MAPK8 MAPK9 | Mitophagy - animal |
| KEGG:04931 | 0.0118173906169 | 0.5 | MAPK8 MAPK9 | Insulin resistance |
| KEGG:04935 | 0.0123049375309 | 0.5 | MAPK8 MAPK9 | Growth hormone synthesis, secretion and action |
| KEGG:04722 | 0.0123049375309 | 0.5 | MAPK8 MAPK9 | Neurotrophin signaling pathway |
| WP:WP428 | 0.0127805971611 | 0.5 | MAPK8 MAPK9 | Wnt signaling |
| WP:WP710 | 0.0127805971611 | 0.5 | MAPK8 MAPK9 | DNA damage response only ATM dependent |
| WP:WP4787 | 0.0130350149263 | 0.5 | MAPK8 MAPK9 | Osteoblast differentiation and related diseases |
| KEGG:04660 | 0.0130545606238 | 0.5 | MAPK8 MAPK9 | T cell receptor signaling pathway |
| KEGG:04071 | 0.0130545606238 | 0.5 | MAPK8 MAPK9 | Sphingolipid signaling pathway |
| WP:WP4659 | 0.0138131669346 | 0.5 | MAPK8 MAPK9 | Gastrin signaling pathway |
| KEGG:04926 | 0.014352694406 | 0.5 | MAPK8 MAPK9 | Relaxin signaling pathway |
| KEGG:04728 | 0.014619629343 | 0.5 | MAPK8 MAPK9 | Dopaminergic synapse |
| REAC:R-HSA-450294 | 0.0157112703152 | 0.5 | MAPK8 MAPK9 | MAP kinase activation |
| KEGG:04068 | 0.0157117070582 | 0.5 | MAPK8 MAPK9 | FoxO signaling pathway |
| KEGG:04380 | 0.0162723391924 | 0.5 | MAPK8 MAPK9 | Osteoclast differentiation |
| KEGG:05135 | 0.0162723391924 | 0.5 | MAPK8 MAPK9 | Yersinia infection |
| WP:WP3915 | 0.0162815495406 | 0.5 | MAPK8 MAPK9 | Angiopoietin like protein 8 regulatory pathway |
| KEGG:05418 | 0.0168426929383 | 0.5 | MAPK8 MAPK9 | Fluid shear stress and atherosclerosis |
| KEGG:04723 | 0.017422762868 | 0.5 | MAPK8 MAPK9 | Retrograde endocannabinoid signaling |
| KEGG:04210 | 0.0177164397058 | 0.5 | MAPK8 MAPK9 | Apoptosis |
| WP:WP366 | 0.0177395403747 | 0.5 | MAPK8 MAPK9 | TGF beta signaling pathway |
| KEGG:05162 | 0.0189154103852 | 0.5 | MAPK8 MAPK9 | Measles |
| KEGG:04936 | 0.0189154103852 | 0.5 | MAPK8 MAPK9 | Alcoholic liver disease |
| WP:WP4630 | 0.01895043011 | 0.5 | MAPK8 MAPK9 | Measles virus infection |
| WP:WP2380 | 0.01895043011 | 0.5 | MAPK8 MAPK9 | Brain derived neurotrophic factor BDNF signaling pathway |
| KEGG:05017 | 0.0192212154966 | 0.5 | MAPK8 MAPK9 | Spinocerebellar ataxia |
| REAC:R-HSA-448424 | 0.019281632575 | 0.5 | MAPK8 MAPK9 | Interleukin-17 signaling |
| KEGG:04910 | 0.0195294442288 | 0.5 | MAPK8 MAPK9 | Insulin signaling pathway |
| KEGG:04217 | 0.0230797254414 | 0.5 | MAPK8 MAPK9 | Necroptosis |
| WP:WP4396 | 0.023499356813 | 0.5 | MAPK8 MAPK9 | Nonalcoholic fatty liver disease |
| WP:WP4666 | 0.023499356813 | 0.5 | MAPK8 MAPK9 | Hepatitis B infection |
| KEGG:04932 | 0.0237566589162 | 0.5 | MAPK8 MAPK9 | Non-alcoholic fatty liver disease |
| KEGG:04530 | 0.0237566589162 | 0.5 | MAPK8 MAPK9 | Tight junction |
| WP:WP481 | 0.0255965717397 | 0.5 | MAPK8 MAPK9 | Insulin signaling |
| WP:WP437 | 0.0259547050416 | 0.5 | MAPK8 MAPK9 | EGF EGFR signaling pathway |
| KEGG:05152 | 0.02620193588 | 0.5 | MAPK8 MAPK9 | Tuberculosis |
| KEGG:04621 | 0.02620193588 | 0.5 | MAPK8 MAPK9 | NOD-like receptor signaling pathway |
| KEGG:05161 | 0.0269222811984 | 0.5 | MAPK8 MAPK9 | Hepatitis B |
| WP:WP4223 | 0.0270438297073 | 0.5 | MAPK8 MAPK9 | Ras signaling |
| KEGG:04310 | 0.0276522587106 | 0.5 | MAPK8 MAPK9 | Wnt signaling pathway |
| KEGG:04141 | 0.0298999303213 | 0.5 | MAPK8 MAPK9 | Protein processing in endoplasmic reticulum |
| KEGG:04140 | 0.0298999303213 | 0.5 | MAPK8 MAPK9 | Autophagy - animal |
| KEGG:04024 | 0.0306683825257 | 0.5 | MAPK8 MAPK9 | cAMP signaling pathway |
| WP:WP3594 | 0.03162086928 | 0.5 | MAPK8 MAPK9 | Circadian rhythm genes |
| KEGG:05130 | 0.0334335704012 | 0.5 | MAPK8 MAPK9 | Pathogenic Escherichia coli infection |
| REAC:R-HSA-168142 | 0.0338007536087 | 0.5 | MAPK8 MAPK9 | Toll Like Receptor 10 (TLR10) Cascade |
| REAC:R-HSA-168176 | 0.0338007536087 | 0.5 | MAPK8 MAPK9 | Toll Like Receptor 5 (TLR5) Cascade |
| REAC:R-HSA-975871 | 0.0338007536087 | 0.5 | MAPK8 MAPK9 | MyD88 cascade initiated on plasma membrane |
| KEGG:05167 | 0.0346546128597 | 0.5 | MAPK8 MAPK9 | Kaposi sarcoma-associated herpesvirus infection |
| REAC:R-HSA-975138 | 0.0354736093287 | 0.5 | MAPK8 MAPK9 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| REAC:R-HSA-975155 | 0.0363250695065 | 0.5 | MAPK8 MAPK9 | MyD88 dependent cascade initiated on endosome |
| REAC:R-HSA-168181 | 0.0363250695065 | 0.5 | MAPK8 MAPK9 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| KEGG:04510 | 0.03673756538 | 0.5 | MAPK8 MAPK9 | Focal adhesion |
| WP:WP306 | 0.0374055211141 | 0.5 | MAPK8 MAPK9 | Focal adhesion |
| KEGG:05417 | 0.0397541089323 | 0.5 | MAPK8 MAPK9 | Lipid and atherosclerosis |
| KEGG:05169 | 0.0397541089323 | 0.5 | MAPK8 MAPK9 | Epstein-Barr virus infection |
| REAC:R-HSA-168138 | 0.0398310607487 | 0.5 | MAPK8 MAPK9 | Toll Like Receptor 9 (TLR9) Cascade |
| KEGG:05415 | 0.0406374666322 | 0.5 | MAPK8 MAPK9 | Diabetic cardiomyopathy |
| KEGG:04014 | 0.0415303647194 | 0.5 | MAPK8 MAPK9 | Ras signaling pathway |
| REAC:R-HSA-168164 | 0.041644107744 | 0.5 | MAPK8 MAPK9 | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-937061 | 0.0434971593242 | 0.5 | MAPK8 MAPK9 | TRIF(TICAM1)-mediated TLR4 signaling |
| REAC:R-HSA-166166 | 0.0434971593242 | 0.5 | MAPK8 MAPK9 | MyD88-independent TLR4 cascade |
| REAC:R-HSA-166058 | 0.0453901932463 | 0.5 | MAPK8 MAPK9 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane |
| REAC:R-HSA-168188 | 0.0453901932463 | 0.5 | MAPK8 MAPK9 | Toll Like Receptor TLR6:TLR2 Cascade |
| KEGG:05170 | 0.0456663239038 | 0.5 | MAPK8 MAPK9 | Human immunodeficiency virus 1 infection |
| REAC:R-HSA-181438 | 0.0473231872721 | 0.5 | MAPK8 MAPK9 | Toll Like Receptor 2 (TLR2) Cascade |
| REAC:R-HSA-168179 | 0.0473231872721 | 0.5 | MAPK8 MAPK9 | Toll Like Receptor TLR1:TLR2 Cascade |
| KEGG:05166 | 0.0480473295333 | 0.5 | MAPK8 MAPK9 | Human T-cell leukemia virus 1 infection |
| KEGG:05208 | 0.049994875911 | 0.5 | MAPK8 MAPK9 | Chemical carcinogenesis - reactive oxygen species |
| KEGG:05171 | 0.049994875911 | 0.5 | MAPK8 MAPK9 | Coronavirus disease - COVID-19 |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| MAPK8 | MAPK9 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| STK11IP | MAPK8 | 0.97 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| MAPK8 | DUSP8 | 0.953 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| DUSP8 | MAPK9 | 0.215 | bioplex_WMM bioplex3_WMM WMM_only | |
| STK11IP | MAPK9 | 0.017 | 0.106 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| MAPK8 | huMAP3_04092.1 huMAP3_12341.1 huMAP3_15127.1 |
| DUSP8 | huMAP3_04092.1 huMAP3_12341.1 huMAP3_15127.1 |
| STK11IP | huMAP3_00068.1 huMAP3_01929.1 huMAP3_04092.1 huMAP3_04094.1 huMAP3_10573.1 huMAP3_11975.1 |
| MAPK9 | huMAP3_04092.1 huMAP3_12341.1 huMAP3_15127.1 |