hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04106.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PALB2 | Partner and localizer of BRCA2 | 5 | UniProt NCBI |
| BRCA2 | Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03440 | 0.000126804361689 | 1.0 | PALB2 BRCA2 | Homologous recombination |
| HP:0005249 | 0.000153788557692 | 1.0 | PALB2 BRCA2 | Functional intestinal obstruction |
| HP:0012334 | 0.000153788557692 | 1.0 | PALB2 BRCA2 | Extrahepatic cholestasis |
| HP:0100592 | 0.000187963792734 | 1.0 | PALB2 BRCA2 | Peritoneal abscess |
| KEGG:03460 | 0.000191181960701 | 1.0 | PALB2 BRCA2 | Fanconi anemia pathway |
| HP:0025318 | 0.000266566833332 | 1.0 | PALB2 BRCA2 | Ovarian carcinoma |
| HP:0030406 | 0.000310994638887 | 1.0 | PALB2 BRCA2 | Primary peritoneal carcinoma |
| HP:0003221 | 0.000358839967947 | 1.0 | PALB2 BRCA2 | Chromosomal breakage induced by crosslinking agents |
| REAC:R-HSA-9709603 | 0.000471618243588 | 1.0 | PALB2 BRCA2 | Impaired BRCA2 binding to PALB2 |
| REAC:R-HSA-9704331 | 0.000512628525639 | 1.0 | PALB2 BRCA2 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function |
| REAC:R-HSA-9701193 | 0.000512628525639 | 1.0 | PALB2 BRCA2 | Defective homologous recombination repair (HRR) due to PALB2 loss of function |
| REAC:R-HSA-9704646 | 0.000512628525639 | 1.0 | PALB2 BRCA2 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function |
| REAC:R-HSA-9701192 | 0.000512628525639 | 1.0 | PALB2 BRCA2 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function |
| HP:0002885 | 0.000584396519228 | 1.0 | PALB2 BRCA2 | Medulloblastoma |
| HP:0012432 | 0.000584396519228 | 1.0 | PALB2 BRCA2 | Chronic fatigue |
| REAC:R-HSA-5693554 | 0.000599775374997 | 1.0 | PALB2 BRCA2 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) |
| HP:0002254 | 0.000649329465809 | 1.0 | PALB2 BRCA2 | Intermittent diarrhea |
| HP:0005522 | 0.000789447929484 | 1.0 | PALB2 BRCA2 | Pyridoxine-responsive sideroblastic anemia |
| HP:0010469 | 0.000864633446577 | 1.0 | PALB2 BRCA2 | Absent testis |
| REAC:R-HSA-5693568 | 0.000902226205124 | 1.0 | PALB2 BRCA2 | Resolution of D-loop Structures through Holliday Junction Intermediates |
| REAC:R-HSA-5693537 | 0.000958615342944 | 1.0 | PALB2 BRCA2 | Resolution of D-Loop Structures |
| HP:0011027 | 0.00111069513888 | 1.0 | PALB2 BRCA2 | Abnormal fallopian tube morphology |
| HP:0012848 | 0.00119955074999 | 1.0 | PALB2 BRCA2 | Small intestinal stenosis |
| HP:0100867 | 0.00119955074999 | 1.0 | PALB2 BRCA2 | Duodenal stenosis |
| HP:0010293 | 0.00119955074999 | 1.0 | PALB2 BRCA2 | Aplasia/Hypoplasia of the uvula |
| WP:WP4016 | 0.00124541391542 | 1.0 | PALB2 BRCA2 | DNA IR damage and cellular response via ATR |
| HP:0002245 | 0.00129182388461 | 1.0 | PALB2 BRCA2 | Meckel diverticulum |
| HP:0100760 | 0.00129182388461 | 1.0 | PALB2 BRCA2 | Clubbing of toes |
| REAC:R-HSA-9701190 | 0.00133283416666 | 1.0 | PALB2 BRCA2 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function |
| REAC:R-HSA-9675136 | 0.00133283416666 | 1.0 | PALB2 BRCA2 | Diseases of DNA Double-Strand Break Repair |
| HP:0004389 | 0.00138751454273 | 1.0 | PALB2 BRCA2 | Intestinal pseudo-obstruction |
| REAC:R-HSA-5693579 | 0.00147124386858 | 1.0 | PALB2 BRCA2 | Homologous DNA Pairing and Strand Exchange |
| HP:0100587 | 0.00148662272435 | 1.0 | PALB2 BRCA2 | Abnormal preputium morphology |
| HP:0001924 | 0.00169509165811 | 1.0 | PALB2 BRCA2 | Sideroblastic anemia |
| HP:0002667 | 0.00180445241025 | 1.0 | PALB2 BRCA2 | Nephroblastoma |
| HP:0012125 | 0.00180445241025 | 1.0 | PALB2 BRCA2 | Prostate cancer |
| HP:0100787 | 0.00180445241025 | 1.0 | PALB2 BRCA2 | Prostate neoplasm |
| HP:0006725 | 0.00191723068589 | 1.0 | PALB2 BRCA2 | Pancreatic adenocarcinoma |
| HP:0011794 | 0.00191723068589 | 1.0 | PALB2 BRCA2 | Embryonal renal neoplasm |
| REAC:R-HSA-9675135 | 0.0020095038205 | 1.0 | PALB2 BRCA2 | Diseases of DNA repair |
| HP:0040012 | 0.00227607065384 | 1.0 | PALB2 BRCA2 | Chromosome breakage |
| HP:0001549 | 0.00227607065384 | 1.0 | PALB2 BRCA2 | Abnormal ileum morphology |
| HP:0008775 | 0.00253238491666 | 1.0 | PALB2 BRCA2 | Abnormal prostate morphology |
| HP:0003003 | 0.00266566833332 | 1.0 | PALB2 BRCA2 | Colon cancer |
| WP:WP4946 | 0.00269343105153 | 1.0 | PALB2 BRCA2 | DNA repair pathways full network |
| HP:0004396 | 0.00294248773717 | 1.0 | PALB2 BRCA2 | Poor appetite |
| HP:0000813 | 0.00338334826922 | 1.0 | PALB2 BRCA2 | Bicornuate uterus |
| REAC:R-HSA-5685942 | 0.00366529395832 | 1.0 | PALB2 BRCA2 | HDR through Homologous Recombination (HRR) |
| HP:0007874 | 0.0038549665128 | 1.0 | PALB2 BRCA2 | Almond-shaped palpebral fissure |
| HP:0033019 | 0.0038549665128 | 1.0 | PALB2 BRCA2 | Male reproductive system neoplasm |
| HP:0025615 | 0.0038549665128 | 1.0 | PALB2 BRCA2 | Abscess |
| HP:0100026 | 0.00401900764101 | 1.0 | PALB2 BRCA2 | Arteriovenous malformation |
| HP:0003022 | 0.00435734246793 | 1.0 | PALB2 BRCA2 | Hypoplasia of the ulna |
| HP:0003220 | 0.00453163616665 | 1.0 | PALB2 BRCA2 | Abnormality of chromosome stability |
| HP:0200005 | 0.00470934738887 | 1.0 | PALB2 BRCA2 | Abnormal shape of the palpebral fissure |
| HP:0002585 | 0.00489047613459 | 1.0 | PALB2 BRCA2 | Abnormal peritoneum morphology |
| HP:0006495 | 0.00507502240382 | 1.0 | PALB2 BRCA2 | Aplasia/Hypoplasia of the ulna |
| HP:0003006 | 0.00526298619656 | 1.0 | PALB2 BRCA2 | Neuroblastoma |
| HP:0004376 | 0.00526298619656 | 1.0 | PALB2 BRCA2 | Neuroblastic tumor |
| HP:0030067 | 0.00526298619656 | 1.0 | PALB2 BRCA2 | Peripheral primitive neuroectodermal neoplasm |
| HP:0007565 | 0.0054543675128 | 1.0 | PALB2 BRCA2 | Multiple cafe-au-lait spots |
| HP:0001738 | 0.00604901660254 | 1.0 | PALB2 BRCA2 | Exocrine pancreatic insufficiency |
| HP:0012092 | 0.00625406801279 | 1.0 | PALB2 BRCA2 | Abnormality of exocrine pancreas physiology |
| HP:0030065 | 0.00625406801279 | 1.0 | PALB2 BRCA2 | Primitive neuroectodermal tumor |
| HP:0002898 | 0.00667442340382 | 1.0 | PALB2 BRCA2 | Embryonal neoplasm |
| HP:0000022 | 0.00667442340382 | 1.0 | PALB2 BRCA2 | Abnormal male internal genitalia morphology |
| HP:0001199 | 0.00688972738458 | 1.0 | PALB2 BRCA2 | Triphalangeal thumb |
| HP:0100615 | 0.00710844888886 | 1.0 | PALB2 BRCA2 | Ovarian neoplasm |
| HP:0003418 | 0.00710844888886 | 1.0 | PALB2 BRCA2 | Back pain |
| HP:0000072 | 0.00733058791663 | 1.0 | PALB2 BRCA2 | Hydroureter |
| HP:0003002 | 0.00755614446791 | 1.0 | PALB2 BRCA2 | Breast carcinoma |
| HP:0002861 | 0.0077851185427 | 1.0 | PALB2 BRCA2 | Melanoma |
| HP:0009821 | 0.00825331926278 | 1.0 | PALB2 BRCA2 | Forearm undergrowth |
| HP:0006501 | 0.00849254590808 | 1.0 | PALB2 BRCA2 | Aplasia/Hypoplasia of the radius |
| HP:0008572 | 0.00948362772432 | 1.0 | PALB2 BRCA2 | External ear malformation |
| HP:0004796 | 0.00973994198714 | 1.0 | PALB2 BRCA2 | Gastrointestinal obstruction |
| HP:0009824 | 0.0105293899166 | 1.0 | PALB2 BRCA2 | Upper limb undergrowth |
| HP:0002246 | 0.0105293899166 | 1.0 | PALB2 BRCA2 | Abnormal duodenum morphology |
| HP:0002894 | 0.0105293899166 | 1.0 | PALB2 BRCA2 | Neoplasm of the pancreas |
| HP:0005344 | 0.0110727761538 | 1.0 | PALB2 BRCA2 | Abnormal carotid artery morphology |
| HP:0030063 | 0.0110727761538 | 1.0 | PALB2 BRCA2 | Neuroepithelial neoplasm |
| HP:0100273 | 0.0110727761538 | 1.0 | PALB2 BRCA2 | Neoplasm of the colon |
| HP:0030060 | 0.0113495955576 | 1.0 | PALB2 BRCA2 | Nervous tissue neoplasm |
| HP:0030061 | 0.0113495955576 | 1.0 | PALB2 BRCA2 | Neuroectodermal neoplasm |
| HP:0002575 | 0.0122005589102 | 1.0 | PALB2 BRCA2 | Tracheoesophageal fistula |
| HP:0010785 | 0.0124910484081 | 1.0 | PALB2 BRCA2 | Gonadal neoplasm |
| HP:0000027 | 0.0127849554294 | 1.0 | PALB2 BRCA2 | Azoospermia |
| REAC:R-HSA-5693567 | 0.0128208394262 | 1.0 | PALB2 BRCA2 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| HP:0006503 | 0.0130822799743 | 1.0 | PALB2 BRCA2 | Aplasia/hypoplasia involving forearm bones |
| HP:0100836 | 0.0130822799743 | 1.0 | PALB2 BRCA2 | Malignant neoplasm of the central nervous system |
| HP:0100013 | 0.0130822799743 | 1.0 | PALB2 BRCA2 | Neoplasm of the breast |
| HP:0002579 | 0.0136871816346 | 1.0 | PALB2 BRCA2 | Gastrointestinal dysmotility |
| REAC:R-HSA-5693538 | 0.0141075370256 | 1.0 | PALB2 BRCA2 | Homology Directed Repair |
| HP:0030895 | 0.0143057533888 | 1.0 | PALB2 BRCA2 | Abnormal gastrointestinal motility |
| HP:0002039 | 0.0165784065192 | 1.0 | PALB2 BRCA2 | Anorexia |
| HP:0012745 | 0.0172584936965 | 1.0 | PALB2 BRCA2 | Short palpebral fissure |
| HP:0009778 | 0.0179522509679 | 1.0 | PALB2 BRCA2 | Short thumb |
| HP:0008669 | 0.0190185183012 | 1.0 | PALB2 BRCA2 | Abnormal spermatogenesis |
| HP:0002863 | 0.0190185183012 | 1.0 | PALB2 BRCA2 | Myelodysplasia |
| HP:0100834 | 0.0193807757926 | 1.0 | PALB2 BRCA2 | Neoplasm of the large intestine |
| HP:0010161 | 0.0193807757926 | 1.0 | PALB2 BRCA2 | Abnormal toe phalanx morphology |
| HP:0001053 | 0.0193807757926 | 1.0 | PALB2 BRCA2 | Hypopigmented skin patches |
| REAC:R-HSA-5693532 | 0.0211937720117 | 1.0 | PALB2 BRCA2 | DNA Double-Strand Break Repair |
| HP:0000957 | 0.0212433261025 | 1.0 | PALB2 BRCA2 | Cafe-au-lait spot |
| HP:0000453 | 0.0216260887349 | 1.0 | PALB2 BRCA2 | Choanal atresia |
| HP:0008055 | 0.0216260887349 | 1.0 | PALB2 BRCA2 | Aplasia/Hypoplasia affecting the uvea |
| HP:0008053 | 0.0216260887349 | 1.0 | PALB2 BRCA2 | Aplasia/Hypoplasia of the iris |
| HP:0002414 | 0.0220122688909 | 1.0 | PALB2 BRCA2 | Spina bifida |
| HP:0009726 | 0.0224018665704 | 1.0 | PALB2 BRCA2 | Renal neoplasm |
| HP:0001217 | 0.0224018665704 | 1.0 | PALB2 BRCA2 | Clubbing |
| HP:0002896 | 0.0235911647499 | 1.0 | PALB2 BRCA2 | Neoplasm of the liver |
| HP:0010786 | 0.0244011178204 | 1.0 | PALB2 BRCA2 | Urinary tract neoplasm |
| HP:0000415 | 0.0248112206409 | 1.0 | PALB2 BRCA2 | Abnormality of the choanae |
| HP:0008062 | 0.0252247409849 | 1.0 | PALB2 BRCA2 | Aplasia/Hypoplasia affecting the anterior segment of the eye |
| HP:0000324 | 0.0256416788524 | 1.0 | PALB2 BRCA2 | Facial asymmetry |
| HP:0010301 | 0.0260620342435 | 1.0 | PALB2 BRCA2 | Spinal dysraphism |
| HP:0009601 | 0.026485807158 | 1.0 | PALB2 BRCA2 | Aplasia/Hypoplasia of the thumb |
| HP:0002023 | 0.026912997596 | 1.0 | PALB2 BRCA2 | Anal atresia |
| HP:0010787 | 0.0282150740512 | 1.0 | PALB2 BRCA2 | Genital neoplasm |
| HP:0000010 | 0.0295479082178 | 1.0 | PALB2 BRCA2 | Recurrent urinary tract infections |
| HP:0002251 | 0.0299990213204 | 1.0 | PALB2 BRCA2 | Aganglionic megacolon |
| HP:0004362 | 0.0299990213204 | 1.0 | PALB2 BRCA2 | Abnormal enteric ganglion morphology |
| HP:0031105 | 0.0299990213204 | 1.0 | PALB2 BRCA2 | Abnormal uterus morphology |
| HP:0012331 | 0.0304535519464 | 1.0 | PALB2 BRCA2 | Abnormal autonomic nervous system morphology |
| HP:0025028 | 0.0304535519464 | 1.0 | PALB2 BRCA2 | Abnormal enteric nervous system morphology |
| HP:0025633 | 0.0304535519464 | 1.0 | PALB2 BRCA2 | Abnormal ureter morphology |
| HP:0040071 | 0.030911500096 | 1.0 | PALB2 BRCA2 | Abnormal morphology of ulna |
| HP:0001433 | 0.030911500096 | 1.0 | PALB2 BRCA2 | Hepatosplenomegaly |
| HP:0001882 | 0.0313728657691 | 1.0 | PALB2 BRCA2 | Leukopenia |
| HP:0012041 | 0.0318376489657 | 1.0 | PALB2 BRCA2 | Decreased fertility in males |
| HP:0012091 | 0.0351868219998 | 1.0 | PALB2 BRCA2 | Abnormality of pancreas physiology |
| HP:0002778 | 0.0381908251601 | 1.0 | PALB2 BRCA2 | Abnormal tracheal morphology |
| HP:0001646 | 0.0392194997349 | 1.0 | PALB2 BRCA2 | Abnormal aortic valve morphology |
| HP:0012145 | 0.0397389633075 | 1.0 | PALB2 BRCA2 | Abnormality of multiple cell lineages in the bone marrow |
| HP:0010468 | 0.0418509928331 | 1.0 | PALB2 BRCA2 | Aplasia/Hypoplasia of the testes |
| HP:0100006 | 0.042927512737 | 1.0 | PALB2 BRCA2 | Neoplasm of the central nervous system |
| HP:0001562 | 0.0440177027348 | 1.0 | PALB2 BRCA2 | Oligohydramnios |
| HP:0001636 | 0.0456786191579 | 1.0 | PALB2 BRCA2 | Tetralogy of Fallot |
| HP:0010972 | 0.0473702932925 | 1.0 | PALB2 BRCA2 | Anemia of inadequate production |
| HP:0000340 | 0.0473702932925 | 1.0 | PALB2 BRCA2 | Sloping forehead |
| HP:0000172 | 0.0479410197177 | 1.0 | PALB2 BRCA2 | Abnormal uvula morphology |
| HP:0045058 | 0.0496737041344 | 1.0 | PALB2 BRCA2 | Abnormality of the testis size |
| REAC:R-HSA-9709275 | 0.0499419797295 | 0.5 | BRCA2 | Impaired BRCA2 translocation to the nucleus |
| REAC:R-HSA-9763198 | 0.0499419797295 | 0.5 | BRCA2 | Impaired BRCA2 binding to SEM1 (DSS1) |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| BRCA2 | PALB2 | 0.998 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
Related Complexes