hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04119.1
Complex Portal: CPX-16581
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TBPL1 | TATA box-binding protein-like 1 (TBP-like 1) (21 kDa TBP-like protein) (Second TBP of unique DNA protein) (STUD) (TATA box-binding protein-related factor 2) (TBP-related factor 2) (TBP-like factor) (TBP-related protein) | 5 | UniProt NCBI |
| GTF2A1 | Transcription initiation factor IIA subunit 1 (General transcription factor IIA subunit 1) (TFIIAL) (Transcription initiation factor TFIIA 42 kDa subunit) (TFIIA-42) [Cleaved into: Transcription initiation factor IIA alpha chain (TFIIA p35 subunit); Transcription initiation factor IIA beta chain (TFIIA p19 subunit)] | 5 | UniProt NCBI |
| GTF2A2 | Transcription initiation factor IIA subunit 2 (General transcription factor IIA subunit 2) (TFIIA p12 subunit) (TFIIA-12) (TFIIAS) (Transcription initiation factor IIA gamma chain) (TFIIA-gamma) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03022 | 5.5686936841e-07 | 1.0 | GTF2A1 TBPL1 GTF2A2 | Basal transcription factors |
| CORUM:490 | 3.41752350426e-06 | 0.666666666667 | GTF2A1 GTF2A2 | TFIIA complex |
| CORUM:489 | 3.41752350426e-06 | 0.666666666667 | GTF2A1 GTF2A2 | TFIIA complex |
| CORUM:1221 | 1.02521027753e-05 | 0.666666666667 | GTF2A1 GTF2A2 | TFIIA-TRF2 complex |
| KEGG:05203 | 5.51248435573e-05 | 1.0 | GTF2A1 TBPL1 GTF2A2 | Viral carcinogenesis |
| CORUM:492 | 0.000358627147418 | 0.666666666667 | GTF2A1 GTF2A2 | DA complex |
| CORUM:493 | 0.000409840887552 | 0.666666666667 | GTF2A1 GTF2A2 | DAB complex |
| GO:0016251 | 0.000746852719164 | 1.0 | GTF2A1 TBPL1 GTF2A2 | RNA polymerase II general transcription initiation factor activity |
| GO:0140223 | 0.00166249223046 | 1.0 | GTF2A1 TBPL1 GTF2A2 | general transcription initiation factor activity |
| GO:0005672 | 0.00421361424067 | 0.666666666667 | GTF2A1 GTF2A2 | transcription factor TFIIA complex |
| REAC:R-HSA-73776 | 0.00673703034894 | 0.666666666667 | GTF2A1 GTF2A2 | RNA Polymerase II Promoter Escape |
| REAC:R-HSA-76042 | 0.00673703034894 | 0.666666666667 | GTF2A1 GTF2A2 | RNA Polymerase II Transcription Initiation And Promoter Clearance |
| REAC:R-HSA-73779 | 0.00673703034894 | 0.666666666667 | GTF2A1 GTF2A2 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| REAC:R-HSA-167161 | 0.00673703034894 | 0.666666666667 | GTF2A1 GTF2A2 | HIV Transcription Initiation |
| REAC:R-HSA-167162 | 0.00673703034894 | 0.666666666667 | GTF2A1 GTF2A2 | RNA Polymerase II HIV Promoter Escape |
| REAC:R-HSA-75953 | 0.00673703034894 | 0.666666666667 | GTF2A1 GTF2A2 | RNA Polymerase II Transcription Initiation |
| REAC:R-HSA-167172 | 0.015485676782 | 0.666666666667 | GTF2A1 GTF2A2 | Transcription of the HIV genome |
| REAC:R-HSA-6807505 | 0.017372320015 | 0.666666666667 | GTF2A1 GTF2A2 | RNA polymerase II transcribes snRNA genes |
| REAC:R-HSA-674695 | 0.0209338694285 | 0.666666666667 | GTF2A1 GTF2A2 | RNA Polymerase II Pre-transcription Events |
| GO:0006352 | 0.0468435252984 | 1.0 | GTF2A1 TBPL1 GTF2A2 | DNA-templated transcription initiation |
| CORUM:629 | 0.0499402709677 | 0.333333333333 | TBPL1 | BLM-TRF2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| GTF2A1 | GTF2A2 | 1.0 | 0.224 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction | |
| GTF2A1 | TBPL1 | 1.0 | 0.12 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| TBPL1 | GTF2A2 | 0.997 | 0.09 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only |
Related Complexes