hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04126.1
Complex Portal: CPX-22913
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| METTL21A | Protein N-lysine methyltransferase METTL21A (EC 2.1.1.-) (HSPA lysine methyltransferase) (HSPA-KMT) (Hepatocellular carcinoma-associated antigen 557b) (Methyltransferase-like protein 21A) | 5 | UniProt NCBI |
| BAG3 | BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1) | 5 | UniProt NCBI |
| HSPA1L | Heat shock 70 kDa protein 1-like (Heat shock 70 kDa protein 1L) (Heat shock 70 kDa protein 1-Hom) (HSP70-Hom) | 5 | UniProt NCBI |
| HSPA2 | Heat shock-related 70 kDa protein 2 (Heat shock 70 kDa protein 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3371453 | 6.1097260824e-05 | 0.75 | BAG3 HSPA1L HSPA2 | Regulation of HSF1-mediated heat shock response |
| REAC:R-HSA-3371556 | 0.000138011947324 | 0.75 | BAG3 HSPA1L HSPA2 | Cellular response to heat stress |
| REAC:R-HSA-3371568 | 0.000798898068561 | 0.5 | HSPA1L HSPA2 | Attenuation phase |
| REAC:R-HSA-3371571 | 0.00258893271292 | 0.5 | HSPA1L HSPA2 | HSF1-dependent transactivation |
| KEGG:04612 | 0.00456536626645 | 0.5 | HSPA1L HSPA2 | Antigen processing and presentation |
| WP:WP2359 | 0.00578263137464 | 0.5 | HSPA1L HSPA2 | Parkin ubiquitin proteasomal system pathway |
| REAC:R-HSA-3371497 | 0.0135329645116 | 0.5 | HSPA1L HSPA2 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand |
| WP:WP4630 | 0.01895043011 | 0.5 | HSPA1L HSPA2 | Measles virus infection |
| KEGG:05417 | 0.0397541089323 | 0.5 | HSPA1L HSPA2 | Lipid and atherosclerosis |
| GO:0031072 | 0.0449670283878 | 0.75 | METTL21A HSPA1L HSPA2 | heat shock protein binding |
| GO:0006986 | 0.0496619752722 | 0.75 | BAG3 HSPA1L HSPA2 | response to unfolded protein |
| CORUM:6078 | 0.049938562206 | 0.25 | HSPA2 | HSPA2-ACR-PDIA6 complex |
| CORUM:6079 | 0.049938562206 | 0.25 | HSPA2 | BAG6-HSPA2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| HSPA1L | HSPA2 | 0.999 | 0.148 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only | |
| BAG3 | METTL21A | 0.994 | 0.078 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| METTL21A | HSPA2 | 0.993 | 0.114 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| BAG3 | HSPA2 | 0.992 | 0.092 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only | |
| METTL21A | HSPA1L | 0.976 | 0.104 |
mutually_exclusive (O95816)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM |
| BAG3 | HSPA1L | 0.914 | 0.185 |
mutually_exclusive (Q8WXB1)
structurally_consistent (dimer) |
bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only |
Related Complexes