hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04144.1
Complex Portal: CPX-18288
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GRB10 | Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR) | 5 | UniProt NCBI |
| WDR24 | GATOR2 complex protein WDR24 (EC 2.3.2.27) (WD repeat-containing protein 24) | 5 | UniProt NCBI |
| WDR59 | GATOR2 complex protein WDR59 (WD repeat-containing protein 59) | 5 | UniProt NCBI |
| SESN2 | Sestrin-2 (EC 1.11.1.-) (Hypoxia-induced gene) | 5 | UniProt NCBI |
| MIOS | GATOR2 complex protein MIOS (Missing oocyte meiosis regulator homolog) | 5 | UniProt NCBI |
| CASTOR2 | Cytosolic arginine sensor for mTORC1 subunit 2 (Cellular arginine sensor for mTORC1 protein 2) (GATS-like protein 2) | 5 | UniProt NCBI |
| NRF1 | Nuclear respiratory factor 1 (NRF-1) (Alpha palindromic-binding protein) (Alpha-pal) | 5 | UniProt NCBI |
| SEH1L | Nucleoporin SEH1 (GATOR2 complex protein SEH1) (Nup107-160 subcomplex subunit SEH1) (SEC13-like protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04150 | 3.71855559749e-12 | 0.875 | SEH1L GRB10 WDR59 WDR24 CASTOR2 SESN2 MIOS | mTOR signaling pathway |
| REAC:R-HSA-9639288 | 1.0059380338e-11 | 0.75 | SEH1L CASTOR2 WDR24 SESN2 MIOS WDR59 | Amino acids regulate mTORC1 |
| CORUM:6216 | 1.68018318789e-11 | 0.5 | SEH1L MIOS WDR24 WDR59 | GATOR2 complex |
| GO:0061700 | 6.34915023291e-11 | 0.625 | SEH1L MIOS CASTOR2 WDR24 WDR59 | GATOR2 complex |
| CORUM:6753 | 2.35071112874e-10 | 0.5 | SEH1L MIOS WDR24 WDR59 | SOG complex |
| CORUM:6217 | 2.35071112874e-10 | 0.5 | SEH1L MIOS WDR24 WDR59 | GATOR complex |
| GO:1904262 | 5.40863140361e-10 | 0.75 | SEH1L CASTOR2 WDR24 SESN2 MIOS WDR59 | negative regulation of TORC1 signaling |
| GO:0035859 | 6.48076439894e-10 | 0.625 | SEH1L MIOS CASTOR2 WDR24 WDR59 | Seh1-associated complex |
| GO:0032007 | 4.63633762928e-09 | 0.75 | SEH1L CASTOR2 WDR24 SESN2 MIOS WDR59 | negative regulation of TOR signaling |
| REAC:R-HSA-9711097 | 6.98619650472e-09 | 0.75 | SEH1L CASTOR2 WDR24 SESN2 MIOS WDR59 | Cellular response to starvation |
| GO:1903432 | 4.48653214139e-08 | 0.75 | SEH1L CASTOR2 WDR24 SESN2 MIOS WDR59 | regulation of TORC1 signaling |
| GO:0038202 | 5.95839661235e-08 | 0.75 | SEH1L CASTOR2 WDR24 SESN2 MIOS WDR59 | TORC1 signaling |
| GO:0032006 | 4.55981197616e-07 | 0.75 | SEH1L CASTOR2 WDR24 SESN2 MIOS WDR59 | regulation of TOR signaling |
| GO:0034198 | 4.82236758531e-07 | 0.625 | SEH1L SESN2 MIOS WDR24 WDR59 | cellular response to amino acid starvation |
| GO:1990928 | 6.11859846001e-07 | 0.625 | SEH1L SESN2 MIOS WDR24 WDR59 | response to amino acid starvation |
| GO:0031929 | 8.7590468485e-07 | 0.75 | SEH1L CASTOR2 WDR24 SESN2 MIOS WDR59 | TOR signaling |
| GO:1904263 | 1.06017052449e-06 | 0.625 | SEH1L SESN2 MIOS WDR24 WDR59 | positive regulation of TORC1 signaling |
| REAC:R-HSA-2262752 | 1.14895565205e-06 | 0.875 | SEH1L GRB10 WDR59 WDR24 CASTOR2 SESN2 MIOS | Cellular responses to stress |
| REAC:R-HSA-8953897 | 1.22892843975e-06 | 0.875 | SEH1L GRB10 WDR59 WDR24 CASTOR2 SESN2 MIOS | Cellular responses to stimuli |
| GO:0032008 | 4.12240046619e-06 | 0.625 | SEH1L SESN2 MIOS WDR24 WDR59 | positive regulation of TOR signaling |
| GO:0009267 | 9.03094814401e-05 | 0.625 | SEH1L SESN2 MIOS WDR24 WDR59 | cellular response to starvation |
| GO:0042594 | 0.000177457328388 | 0.625 | SEH1L SESN2 MIOS WDR24 WDR59 | response to starvation |
| GO:0031669 | 0.000415640824511 | 0.625 | SEH1L SESN2 MIOS WDR24 WDR59 | cellular response to nutrient levels |
| GO:1902532 | 0.000472346511415 | 0.75 | SEH1L CASTOR2 WDR24 SESN2 MIOS WDR59 | negative regulation of intracellular signal transduction |
| GO:0031668 | 0.000546529050406 | 0.625 | SEH1L SESN2 MIOS WDR24 WDR59 | cellular response to extracellular stimulus |
| GO:0009968 | 0.00108906957513 | 0.875 | SEH1L GRB10 WDR59 WDR24 CASTOR2 SESN2 MIOS | negative regulation of signal transduction |
| GO:0010648 | 0.00136404184275 | 0.875 | SEH1L GRB10 WDR59 WDR24 CASTOR2 SESN2 MIOS | negative regulation of cell communication |
| GO:0071496 | 0.00136551227465 | 0.625 | SEH1L SESN2 MIOS WDR24 WDR59 | cellular response to external stimulus |
| GO:0023057 | 0.00142778628397 | 0.875 | SEH1L GRB10 WDR59 WDR24 CASTOR2 SESN2 MIOS | negative regulation of signaling |
| GO:0031667 | 0.00194857551246 | 0.625 | SEH1L SESN2 MIOS WDR24 WDR59 | response to nutrient levels |
| GO:0009991 | 0.00249040444725 | 0.625 | SEH1L SESN2 MIOS WDR24 WDR59 | response to extracellular stimulus |
| GO:0048585 | 0.00518576601331 | 0.875 | SEH1L GRB10 WDR59 WDR24 CASTOR2 SESN2 MIOS | negative regulation of response to stimulus |
| GO:0098852 | 0.0141938744355 | 0.625 | SEH1L SESN2 MIOS WDR24 WDR59 | lytic vacuole membrane |
| GO:0005765 | 0.0141938744355 | 0.625 | SEH1L SESN2 MIOS WDR24 WDR59 | lysosomal membrane |
| GO:0005774 | 0.0207850704339 | 0.625 | SEH1L SESN2 MIOS WDR24 WDR59 | vacuolar membrane |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| WDR59 | NRF1 | 0.996 | 0.162 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| WDR59 | SEH1L | 0.996 | 0.174 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () boldt_WMM |
| MIOS | SEH1L | 0.994 | 0.184 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM hein () boldt_WMM |
| WDR24 | MIOS | 0.994 | 0.108 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| GRB10 | WDR59 | 0.993 | 0.078 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MIOS | CASTOR2 | 0.993 | 0.064 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| WDR24 | WDR59 | 0.993 | 0.146 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM WMM_only boldt_WMM |
| WDR59 | SESN2 | 0.99 | 0.116 |
mutually_exclusive (Q96EE3)
|
hein_WMM bioplex_WMM bioplex3_WMM hein () |
| WDR24 | SESN2 | 0.987 | 0.142 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| WDR59 | MIOS | 0.987 | 0.298 |
structurally_consistent (Q96S15)
|
hein_WMM bioplex_WMM bioplex3_WMM WMM_only boldt_WMM |
| CASTOR2 | SEH1L | 0.982 | 0.028 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| WDR24 | CASTOR2 | 0.98 | 0.084 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| SEH1L | SESN2 | 0.979 | 0.092 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM hein () |
| MIOS | SESN2 | 0.977 | 0.096 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| WDR59 | CASTOR2 | 0.977 | 0.034 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| WDR24 | SEH1L | 0.956 | 0.11 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM hein () boldt_WMM |
| GRB10 | NRF1 | 0.89 | 0.064 | bioplex_WMM bioplex3_WMM WMM_only | |
| CASTOR2 | SESN2 | 0.664 | 0.114 | hein_WMM hein () |
Related Complexes