hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04153.1
Complex Portal: CPX-11390
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| FARSA | Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (CML33) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS) | 5 | UniProt NCBI |
| FARSB | Phenylalanine--tRNA ligase beta subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase beta subunit) (PheRS) | 5 | UniProt NCBI |
| AASS | Alpha-aminoadipic semialdehyde synthase, mitochondrial (LKR/SDH) [Includes: Lysine ketoglutarate reductase (LKR) (LOR) (EC 1.5.1.8); Saccharopine dehydrogenase (SDH) (EC 1.5.1.9)] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00970 | 0.000688034410789 | 0.666666666667 | FARSB FARSA | Aminoacyl-tRNA biosynthesis |
| GO:0009328 | 0.00140460216025 | 0.666666666667 | FARSB FARSA | phenylalanine-tRNA ligase complex |
| REAC:R-HSA-379716 | 0.00188000535098 | 0.666666666667 | FARSB FARSA | Cytosolic tRNA aminoacylation |
| GO:0006432 | 0.00421361424067 | 0.666666666667 | FARSB FARSA | phenylalanyl-tRNA aminoacylation |
| REAC:R-HSA-379724 | 0.00585997836812 | 0.666666666667 | FARSB FARSA | tRNA Aminoacylation |
| GO:0004826 | 0.00842684400117 | 0.666666666667 | FARSB FARSA | phenylalanine-tRNA ligase activity |
| HP:0001903 | 0.0189203502844 | 1.0 | FARSB FARSA AASS | Anemia |
| HP:0012379 | 0.0204103893061 | 1.0 | FARSB FARSA AASS | Abnormal circulating enzyme concentration or activity |
| HP:0010876 | 0.0228523059604 | 1.0 | FARSB FARSA AASS | Abnormal circulating protein concentration |
| HP:0001877 | 0.0249404281241 | 1.0 | FARSB FARSA AASS | Abnormal erythrocyte morphology |
| HP:0034684 | 0.0263079825031 | 1.0 | FARSB FARSA AASS | Abnormal enzyme concentration or activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| FARSA | FARSB | 0.999 | 0.972 | bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction treiber_WMM | |
| AASS | FARSA | 0.968 | 0.036 | bioplex_WMM Guru bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM | |
| AASS | FARSB | 0.006 | 0.0625714285714 | bioplex3_WMM youn_WMM fraction |
Related Complexes