hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04172.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| KICS2 | KICSTOR subunit 2 (KICSTOR complex protein C12orf66) | 5 | UniProt NCBI |
| SZT2 | KICSTOR complex protein SZT2 (Seizure threshold 2 protein homolog) | 5 | UniProt NCBI |
| ITFG2 | KICSTOR complex protein ITFG2 (Integrin-alpha FG-GAP repeat-containing protein 2) | 5 | UniProt NCBI |
| TMCO4 | Transmembrane and coiled-coil domain-containing protein 4 | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6754 | 2.80628050973e-09 | 0.75 | KICS2 ITFG2 SZT2 | KICSTOR complex |
| GO:0140007 | 1.53784171933e-06 | 0.75 | KICS2 ITFG2 SZT2 | KICSTOR complex |
| REAC:R-HSA-9639288 | 3.27872895639e-05 | 0.75 | KICS2 ITFG2 SZT2 | Amino acids regulate mTORC1 |
| REAC:R-HSA-9711097 | 0.00081494341463 | 0.75 | KICS2 ITFG2 SZT2 | Cellular response to starvation |
| GO:0042149 | 0.0037914498893 | 0.75 | KICS2 ITFG2 SZT2 | cellular response to glucose starvation |
| GO:1904262 | 0.00440499676786 | 0.75 | KICS2 ITFG2 SZT2 | negative regulation of TORC1 signaling |
| GO:0034198 | 0.00473512798232 | 0.75 | KICS2 ITFG2 SZT2 | cellular response to amino acid starvation |
| GO:1990928 | 0.00544401218013 | 0.75 | KICS2 ITFG2 SZT2 | response to amino acid starvation |
| GO:0032007 | 0.0124631389739 | 0.75 | KICS2 ITFG2 SZT2 | negative regulation of TOR signaling |
| GO:1903432 | 0.0378152735667 | 0.75 | KICS2 ITFG2 SZT2 | regulation of TORC1 signaling |
| GO:0038202 | 0.0434703685672 | 0.75 | KICS2 ITFG2 SZT2 | TORC1 signaling |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SZT2 | ITFG2 | 1.0 | 0.156 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| KICS2 | ITFG2 | 0.999 | 0.134 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| KICS2 | SZT2 | 0.989 | 0.066 | bioplex_WMM bioplex3_WMM WMM_only |
| ITFG2 | TMCO4 | 0.967 | 0.124 | bioplex_WMM bioplex3_WMM WMM_only |
| SZT2 | TMCO4 | 0.962 | 0.132 | bioplex_WMM bioplex3_WMM WMM_only |
| KICS2 | TMCO4 | 0.961 | 0.064 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes