hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04178.1
Complex Portal: CPX-19002
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| POLE4 | DNA polymerase epsilon subunit 4 (DNA polymerase II subunit 4) (DNA polymerase epsilon subunit p12) | 5 | UniProt NCBI |
| CHRAC1 | Chromatin accessibility complex protein 1 (CHRAC-1) (Chromatin accessibility complex 15 kDa protein) (CHRAC-15) (HuCHRAC15) (DNA polymerase epsilon subunit p15) | 5 | UniProt NCBI |
| POLE2 | DNA polymerase epsilon subunit 2 (DNA polymerase II subunit 2) (DNA polymerase epsilon subunit B) | 5 | UniProt NCBI |
| POLE3 | DNA polymerase epsilon subunit 3 (Arsenic-transactivated protein) (AsTP) (Chromatin accessibility complex 17 kDa protein) (CHRAC-17) (HuCHRAC17) (DNA polymerase II subunit 3) (DNA polymerase epsilon subunit p17) | 5 | UniProt NCBI |
| POLE | DNA polymerase epsilon catalytic subunit A (EC 2.7.7.7) (3'-5' exodeoxyribonuclease) (EC 3.1.11.-) (DNA polymerase II subunit A) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0008622 | 9.00439087303e-15 | 1.0 | POLE POLE4 POLE3 POLE2 CHRAC1 | epsilon DNA polymerase complex |
| REAC:R-HSA-68952 | 2.98941684079e-11 | 0.8 | POLE POLE4 POLE2 POLE3 | DNA replication initiation |
| GO:0003887 | 1.04703057072e-10 | 1.0 | POLE POLE4 POLE3 POLE2 CHRAC1 | DNA-directed DNA polymerase activity |
| GO:0042575 | 1.39604076095e-10 | 1.0 | POLE POLE4 POLE3 POLE2 CHRAC1 | DNA polymerase complex |
| CORUM:1108 | 2.74114580914e-10 | 0.8 | POLE POLE4 POLE2 POLE3 | DNA synthesome complex (15 subunits) |
| CORUM:1111 | 3.83739390783e-10 | 0.8 | POLE POLE4 POLE2 POLE3 | DNA synthesome complex (17 subunits) |
| CORUM:1099 | 3.83739390783e-10 | 0.8 | POLE POLE4 POLE2 POLE3 | DNA synthesome complex (17 subunits) |
| GO:0034061 | 4.78403287084e-10 | 1.0 | POLE POLE4 POLE3 POLE2 CHRAC1 | DNA polymerase activity |
| WP:WP531 | 1.46203490319e-09 | 0.8 | POLE POLE4 POLE2 POLE3 | DNA mismatch repair |
| REAC:R-HSA-5651801 | 2.55413169334e-09 | 0.8 | POLE POLE4 POLE2 POLE3 | PCNA-Dependent Long Patch Base Excision Repair |
| WP:WP4752 | 4.52305973006e-09 | 0.8 | POLE POLE4 POLE2 POLE3 | Base excision repair |
| REAC:R-HSA-5696397 | 5.39727369539e-09 | 0.8 | POLE POLE4 POLE2 POLE3 | Gap-filling DNA repair synthesis and ligation in GG-NER |
| REAC:R-HSA-110373 | 5.39727369539e-09 | 0.8 | POLE POLE4 POLE2 POLE3 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway |
| KEGG:03030 | 7.51082457735e-09 | 0.8 | POLE POLE4 POLE2 POLE3 | DNA replication |
| REAC:R-HSA-110314 | 1.16894660556e-08 | 0.8 | POLE POLE4 POLE2 POLE3 | Recognition of DNA damage by PCNA-containing replication complex |
| REAC:R-HSA-5656169 | 1.34205029003e-08 | 0.8 | POLE POLE4 POLE2 POLE3 | Termination of translesion DNA synthesis |
| KEGG:03410 | 1.57296490579e-08 | 0.8 | POLE POLE4 POLE2 POLE3 | Base excision repair |
| REAC:R-HSA-68962 | 1.74513507793e-08 | 0.8 | POLE POLE4 POLE2 POLE3 | Activation of the pre-replicative complex |
| WP:WP4753 | 2.03536916201e-08 | 0.8 | POLE POLE4 POLE2 POLE3 | Nucleotide excision repair |
| REAC:R-HSA-73933 | 2.23277738459e-08 | 0.8 | POLE POLE4 POLE2 POLE3 | Resolution of Abasic Sites (AP sites) |
| REAC:R-HSA-110313 | 3.1471608967e-08 | 0.8 | POLE POLE4 POLE2 POLE3 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template |
| REAC:R-HSA-5696400 | 4.31701598099e-08 | 0.8 | POLE POLE4 POLE2 POLE3 | Dual Incision in GG-NER |
| KEGG:03420 | 5.40322943081e-08 | 0.8 | POLE POLE4 POLE2 POLE3 | Nucleotide excision repair |
| REAC:R-HSA-73893 | 7.60097837806e-08 | 0.8 | POLE POLE4 POLE2 POLE3 | DNA Damage Bypass |
| WP:WP5114 | 1.79216443484e-07 | 0.8 | POLE POLE4 POLE2 POLE3 | Nucleotide excision repair in xeroderma pigmentosum |
| REAC:R-HSA-6782210 | 2.53618197426e-07 | 0.8 | POLE POLE4 POLE2 POLE3 | Gap-filling DNA repair synthesis and ligation in TC-NER |
| REAC:R-HSA-6782135 | 2.70511217063e-07 | 0.8 | POLE POLE4 POLE2 POLE3 | Dual incision in TC-NER |
| REAC:R-HSA-5685942 | 3.06812697185e-07 | 0.8 | POLE POLE4 POLE2 POLE3 | HDR through Homologous Recombination (HRR) |
| REAC:R-HSA-73884 | 5.45866299098e-07 | 0.8 | POLE POLE4 POLE2 POLE3 | Base Excision Repair |
| REAC:R-HSA-6781827 | 5.75745130806e-07 | 0.8 | POLE POLE4 POLE2 POLE3 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| GO:0016779 | 6.11495963981e-07 | 1.0 | POLE POLE4 POLE3 POLE2 CHRAC1 | nucleotidyltransferase activity |
| REAC:R-HSA-5696399 | 7.8154979472e-07 | 0.8 | POLE POLE4 POLE2 POLE3 | Global Genome Nucleotide Excision Repair (GG-NER) |
| WP:WP4946 | 1.05784593025e-06 | 0.8 | POLE POLE4 POLE2 POLE3 | DNA repair pathways full network |
| REAC:R-HSA-5696398 | 2.27611882554e-06 | 0.8 | POLE POLE4 POLE2 POLE3 | Nucleotide Excision Repair |
| REAC:R-HSA-69239 | 3.37055878382e-06 | 0.8 | POLE POLE4 POLE2 POLE3 | Synthesis of DNA |
| REAC:R-HSA-5693567 | 3.85269753617e-06 | 0.8 | POLE POLE4 POLE2 POLE3 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| GO:0006261 | 3.89255444008e-06 | 1.0 | POLE POLE4 POLE3 POLE2 CHRAC1 | DNA-templated DNA replication |
| REAC:R-HSA-5693538 | 4.67050314665e-06 | 0.8 | POLE POLE4 POLE2 POLE3 | Homology Directed Repair |
| REAC:R-HSA-69206 | 4.81850742601e-06 | 0.8 | POLE POLE4 POLE2 POLE3 | G1/S Transition |
| REAC:R-HSA-453279 | 7.91332898893e-06 | 0.8 | POLE POLE4 POLE2 POLE3 | Mitotic G1 phase and G1/S transition |
| REAC:R-HSA-69002 | 7.91332898893e-06 | 0.8 | POLE POLE4 POLE2 POLE3 | DNA Replication Pre-Initiation |
| REAC:R-HSA-5693532 | 1.05854142603e-05 | 0.8 | POLE POLE4 POLE2 POLE3 | DNA Double-Strand Break Repair |
| REAC:R-HSA-69242 | 1.08579866423e-05 | 0.8 | POLE POLE4 POLE2 POLE3 | S Phase |
| GO:0000228 | 1.09693117519e-05 | 1.0 | POLE POLE4 POLE3 POLE2 CHRAC1 | nuclear chromosome |
| REAC:R-HSA-69306 | 1.56110049701e-05 | 0.8 | POLE POLE4 POLE2 POLE3 | DNA Replication |
| GO:0140097 | 1.90713046234e-05 | 1.0 | POLE POLE4 POLE3 POLE2 CHRAC1 | catalytic activity, acting on DNA |
| GO:0006260 | 3.28944967066e-05 | 1.0 | POLE POLE4 POLE3 POLE2 CHRAC1 | DNA replication |
| CORUM:234 | 8.18785830799e-05 | 0.4 | CHRAC1 POLE3 | HuCHRAC complex |
| GO:0061695 | 0.000115876930584 | 1.0 | POLE POLE4 POLE3 POLE2 CHRAC1 | transferase complex, transferring phosphorus-containing groups |
| REAC:R-HSA-73894 | 0.000150476434856 | 0.8 | POLE POLE4 POLE2 POLE3 | DNA Repair |
| CORUM:6665 | 0.00124012622854 | 0.4 | POLE4 POLE3 | ATAC complex, YEATS2-linked |
| REAC:R-HSA-69278 | 0.00130844914147 | 0.8 | POLE POLE4 POLE2 POLE3 | Cell Cycle, Mitotic |
| GO:0140640 | 0.00216316494388 | 1.0 | POLE POLE4 POLE3 POLE2 CHRAC1 | catalytic activity, acting on a nucleic acid |
| REAC:R-HSA-1640170 | 0.00298118644627 | 0.8 | POLE POLE4 POLE2 POLE3 | Cell Cycle |
| WP:WP466 | 0.00503666229327 | 0.4 | POLE POLE2 | DNA replication |
| WP:WP45 | 0.0117576408425 | 0.4 | POLE POLE2 | G1 to S cell cycle control |
| GO:0016772 | 0.0119931908441 | 1.0 | POLE POLE4 POLE3 POLE2 CHRAC1 | transferase activity, transferring phosphorus-containing groups |
| GO:0006259 | 0.0192772113985 | 1.0 | POLE POLE4 POLE3 POLE2 CHRAC1 | DNA metabolic process |
| GO:1990234 | 0.0209786718727 | 1.0 | POLE POLE4 POLE3 POLE2 CHRAC1 | transferase complex |
| WP:WP2446 | 0.0212523049113 | 0.4 | POLE POLE2 | Retinoblastoma gene in cancer |
| KEGG:03082 | 0.024008315736 | 0.4 | CHRAC1 POLE3 | ATP-dependent chromatin remodeling |
| GO:0140535 | 0.0279888888248 | 1.0 | POLE POLE4 POLE3 POLE2 CHRAC1 | intracellular protein-containing complex |
| GO:0006272 | 0.0280843539964 | 0.4 | POLE3 POLE | leading strand elongation |
| GO:0008623 | 0.0280843539964 | 0.4 | CHRAC1 POLE3 | CHRAC |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| POLE2 | POLE | 1.0 | 0.358 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM Malo bioplex3_HCT116 fraction | |
| POLE4 | POLE2 | 1.0 | 0.124 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| POLE4 | POLE3 | 0.999 | 0.326 |
mutually_exclusive (Q9NRG0)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM Malo bioplex3_HCT116 fraction |
| CHRAC1 | POLE3 | 0.999 | 0.956 |
mutually_exclusive (Q9NR33)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM bioplex3_HCT116 fraction |
| POLE3 | POLE | 0.999 | 0.108 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM Malo bioplex3_HCT116 fraction | |
| POLE2 | POLE3 | 0.998 | 0.112 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| POLE4 | POLE | 0.995 | 0.112 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM Malo bioplex3_HCT116 fraction | |
| POLE4 | CHRAC1 | 0.274 | 0.19 |
structurally_consistent (dimer)
|
bioplex3_WMM WMM_only |
| CHRAC1 | POLE2 | 0.167 | 0.116 | bioplex3_WMM WMM_only | |
| CHRAC1 | POLE | 0.146 | 0.02 | bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| POLE4 | huMAP3_04178.1 huMAP3_06746.1 huMAP3_14197.1 |
| CHRAC1 | huMAP3_04178.1 huMAP3_06403.1 huMAP3_06746.1 huMAP3_13332.1 huMAP3_15153.1 |
| POLE2 | huMAP3_04178.1 huMAP3_06746.1 huMAP3_14197.1 |
| POLE3 | huMAP3_04178.1 huMAP3_06403.1 huMAP3_06746.1 huMAP3_14197.1 |
| POLE | huMAP3_04178.1 huMAP3_06746.1 huMAP3_14197.1 |