hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_04180.1
Complex Portal: CPX-21138
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DYNLL2 | Dynein light chain 2, cytoplasmic (8 kDa dynein light chain b) (DLC8b) (Dynein light chain LC8-type 2) | 5 | UniProt NCBI |
| DYNLL1 | Dynein light chain 1, cytoplasmic (8 kDa dynein light chain) (DLC8) (Dynein light chain LC8-type 1) (Protein inhibitor of neuronal nitric oxide synthase) (PIN) | 5 | UniProt NCBI |
| TP53BP1 | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | 5 | UniProt NCBI |
| ZNF710 | Zinc finger protein 710 | 3 | UniProt NCBI |
| MORC3 | MORC family CW-type zinc finger protein 3 (Nuclear matrix protein 2) (Zinc finger CW-type coiled-coil domain protein 3) | 5 | UniProt NCBI |
| ZNF608 | Zinc finger protein 608 (Renal carcinoma antigen NY-REN-36) | 3 | UniProt NCBI |
| ATMIN | ATM interactor (ATM/ATR-substrate CHK2-interacting zinc finger protein) (ASCIZ) (Zinc finger protein 822) | 5 | UniProt NCBI |
| BCL2L11 | Bcl-2-like protein 11 (Bcl2-L-11) (Bcl2-interacting mediator of cell death) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-114452 | 9.23525641109e-05 | 0.375 | DYNLL2 DYNLL1 BCL2L11 | Activation of BH3-only proteins |
| REAC:R-HSA-111446 | 0.000167311042734 | 0.25 | DYNLL1 BCL2L11 | Activation of BIM and translocation to mitochondria |
| REAC:R-HSA-109606 | 0.000499872649354 | 0.375 | DYNLL2 DYNLL1 BCL2L11 | Intrinsic Pathway for Apoptosis |
| CORUM:6236 | 0.00157457895347 | 0.25 | DYNLL2 DYNLL1 | Dynein-2 complex, cytoplasmic |
| WP:WP4532 | 0.00833957037235 | 0.25 | DYNLL2 DYNLL1 | Intraflagellar transport proteins binding to dynein |
| KEGG:04962 | 0.0100194502952 | 0.25 | DYNLL2 DYNLL1 | Vasopressin-regulated water reabsorption |
| REAC:R-HSA-109581 | 0.0164434726177 | 0.375 | DYNLL2 DYNLL1 BCL2L11 | Apoptosis |
| WP:WP5085 | 0.0184665051061 | 0.25 | DYNLL2 DYNLL1 | Vasopressin regulated water reabsorption |
| WP:WP3878 | 0.0194081878965 | 0.25 | TP53BP1 ATMIN | ATM signaling in development and disease |
| REAC:R-HSA-5357801 | 0.0261261838654 | 0.375 | DYNLL2 DYNLL1 BCL2L11 | Programmed Cell Death |
| WP:WP4906 | 0.0376097283422 | 0.25 | DYNLL2 DYNLL1 | 3q29 copy number variation syndrome |
| REAC:R-HSA-9646399 | 0.0452582424141 | 0.25 | DYNLL2 DYNLL1 | Aggrephagy |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| DYNLL1 | MORC3 | 0.995 | 0.222 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM hein () boldt_WMM | |
| DYNLL2 | DYNLL1 | 0.99 | 0.214 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only |
| BCL2L11 | DYNLL2 | 0.982 | 0.116 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| DYNLL2 | MORC3 | 0.979 | 0.088 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| BCL2L11 | DYNLL1 | 0.973 | 0.144 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM | |
| DYNLL1 | TP53BP1 | 0.972 | 0.112 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () boldt_WMM | |
| DYNLL1 | ZNF710 | 0.959 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| DYNLL1 | ATMIN | 0.958 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt_WMM | ||
| DYNLL1 | ZNF608 | 0.954 | 0.342 | bioplex3_HEK293 bioplex3_WMM youn_WMM WMM_only | |
| DYNLL2 | ZNF608 | 0.897 | 0.142 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| DYNLL2 | ZNF710 | 0.89 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| DYNLL2 | ATMIN | 0.776 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt_WMM | ||
| DYNLL2 | TP53BP1 | 0.494 | 0.09 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM boldt_WMM WMM_only | |
| ZNF710 | ZNF608 | 0.391 | bioplex3_WMM WMM_only | ||
| ZNF710 | ATMIN | 0.391 | bioplex3_WMM WMM_only | ||
| MORC3 | ATMIN | 0.196 | bioplex3_WMM WMM_only boldt_WMM | ||
| ZNF710 | MORC3 | 0.135 | bioplex3_WMM WMM_only | ||
| ZNF608 | ATMIN | 0.135 | bioplex3_WMM WMM_only | ||
| MORC3 | ZNF608 | 0.114 | 0.152 | bioplex3_WMM youn_WMM WMM_only | |
| TP53BP1 | ATMIN | 0.108 | bioplex3_WMM WMM_only boldt_WMM | ||
| TP53BP1 | ZNF710 | 0.095 | bioplex3_WMM WMM_only | ||
| TP53BP1 | ZNF608 | 0.089 | 0.124 | bioplex3_WMM youn_WMM WMM_only | |
| TP53BP1 | MORC3 | 0.081 | 0.042 | bioplex3_WMM youn_WMM WMM_only boldt_WMM | |
| BCL2L11 | MORC3 | 0.079 | 0.086 | bioplex3_WMM WMM_only | |
| BCL2L11 | ZNF710 | 0.079 | bioplex3_WMM WMM_only | ||
| BCL2L11 | ATMIN | 0.079 | bioplex3_WMM WMM_only | ||
| BCL2L11 | ZNF608 | 0.079 | 0.086 | bioplex3_WMM WMM_only | |
| BCL2L11 | TP53BP1 | 0.07 | 0.076 | bioplex3_WMM WMM_only |
Related Complexes