hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04185.1
Complex Portal: CPX-13020
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| IRGQ | Immunity-related GTPase family Q protein | 2 | UniProt NCBI |
| PNP | Purine nucleoside phosphorylase (PNP) (EC 2.4.2.1) (Inosine phosphorylase) (Inosine-guanosine phosphorylase) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9735763 | 0.0249718442457 | 0.5 | PNP | Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine |
| REAC:R-HSA-9735786 | 0.0249718442457 | 0.5 | PNP | Nucleotide catabolism defects |
| CORUM:6208 | 0.0249718442457 | 0.5 | PNP | PNP homotrimer complex |
| HP:0032166 | 0.0499436884913 | 0.5 | PNP | Unusual gastrointestinal infection |
| HP:0033339 | 0.0499436884913 | 0.5 | PNP | Increased circulating inosine concentration |
| HP:0033340 | 0.0499436884913 | 0.5 | PNP | Increased circulating guanosine concentration |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| IRGQ | PNP | 0.973 | 0.04 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| IRGQ | huMAP3_04185.1 huMAP3_14510.1 huMAP3_14713.1 |
| PNP | huMAP3_04185.1 |