hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04201.1
Complex Portal: CPX-11988
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GRIN3B | Glutamate receptor ionotropic, NMDA 3B (GluN3B) (N-methyl-D-aspartate receptor subtype 3B) (NMDAR3B) (NR3B) | 5 | UniProt NCBI |
| GRIN3A | Glutamate receptor ionotropic, NMDA 3A (GluN3A) (N-methyl-D-aspartate receptor subtype 3A) (NMDAR3A) (NR3A) (NMDAR-L) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP5398 | 3.87329686614e-05 | 1.0 | GRIN3B GRIN3A | NRXN1 deletion syndrome |
| KEGG:05033 | 4.48692356747e-05 | 1.0 | GRIN3B GRIN3A | Nicotine addiction |
| KEGG:05030 | 0.000133307149468 | 1.0 | GRIN3B GRIN3A | Cocaine addiction |
| KEGG:05031 | 0.00025946123238 | 1.0 | GRIN3B GRIN3A | Amphetamine addiction |
| WP:WP4539 | 0.000402652619272 | 1.0 | GRIN3B GRIN3A | Synaptic signaling pathways associated with autism spectrum disorder |
| KEGG:04724 | 0.000526725810094 | 1.0 | GRIN3B GRIN3A | Glutamatergic synapse |
| REAC:R-HSA-9609736 | 0.00120125951175 | 1.0 | GRIN3B GRIN3A | Assembly and cell surface presentation of NMDA receptors |
| KEGG:05017 | 0.00125991513217 | 1.0 | GRIN3B GRIN3A | Spinocerebellar ataxia |
| KEGG:05034 | 0.00179249345126 | 1.0 | GRIN3B GRIN3A | Alcoholism |
| KEGG:04024 | 0.00201635192055 | 1.0 | GRIN3B GRIN3A | cAMP signaling pathway |
| KEGG:04020 | 0.00239074992693 | 1.0 | GRIN3B GRIN3A | Calcium signaling pathway |
| WP:WP5083 | 0.00259851399646 | 1.0 | GRIN3B GRIN3A | Neuroinflammation and glutamatergic signaling |
| KEGG:04080 | 0.00282724955659 | 1.0 | GRIN3B GRIN3A | Neuroactive ligand-receptor interaction |
| GO:0017146 | 0.00468200720083 | 1.0 | GRIN3B GRIN3A | NMDA selective glutamate receptor complex |
| GO:0004972 | 0.00468200720083 | 1.0 | GRIN3B GRIN3A | NMDA glutamate receptor activity |
| KEGG:05020 | 0.00485920816781 | 1.0 | GRIN3B GRIN3A | Prion disease |
| REAC:R-HSA-442755 | 0.00539968713673 | 1.0 | GRIN3B GRIN3A | Activation of NMDA receptors and postsynaptic events |
| WP:WP5420 | 0.0144418640295 | 1.0 | GRIN3B GRIN3A | ADHD and autism ASD linked metabolic pathways and SNP |
| GO:0016594 | 0.016855225923 | 1.0 | GRIN3B GRIN3A | glycine binding |
| GO:0035235 | 0.0210690324038 | 1.0 | GRIN3B GRIN3A | ionotropic glutamate receptor signaling pathway |
| GO:1990806 | 0.0210690324038 | 1.0 | GRIN3B GRIN3A | ligand-gated ion channel signaling pathway |
| GO:0004970 | 0.0210690324038 | 1.0 | GRIN3B GRIN3A | glutamate-gated receptor activity |
| REAC:R-HSA-112314 | 0.0211937720117 | 1.0 | GRIN3B GRIN3A | Neurotransmitter receptors and postsynaptic signal transmission |
| REAC:R-HSA-112315 | 0.0350347422039 | 1.0 | GRIN3B GRIN3A | Transmission across Chemical Synapses |
| GO:0008066 | 0.0426062655276 | 1.0 | GRIN3B GRIN3A | glutamate receptor activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| GRIN3B | GRIN3A | 0.987 | bioplex3_HEK293 bioplex3_WMM WMM_only |
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