hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_04213.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RMI2 | RecQ-mediated genome instability protein 2 (hRMI2) (BLM-associated protein of 18 kDa) (BLAP18) | 5 | UniProt NCBI |
| TOP3A | DNA topoisomerase 3-alpha (EC 5.6.2.1) (DNA topoisomerase III alpha) | 5 | UniProt NCBI |
| RMI1 | RecQ-mediated genome instability protein 1 (BLM-associated protein of 75 kDa) (BLAP75) (FAAP75) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0031422 | 3.84480164306e-07 | 1.0 | RMI1 RMI2 TOP3A | RecQ family helicase-topoisomerase III complex |
| REAC:R-HSA-9709603 | 9.44402733683e-07 | 1.0 | RMI1 RMI2 TOP3A | Impaired BRCA2 binding to PALB2 |
| KEGG:03460 | 9.62454150431e-07 | 1.0 | RMI1 RMI2 TOP3A | Fanconi anemia pathway |
| REAC:R-HSA-9704331 | 1.07318492464e-06 | 1.0 | RMI1 RMI2 TOP3A | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function |
| REAC:R-HSA-9704646 | 1.07318492464e-06 | 1.0 | RMI1 RMI2 TOP3A | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function |
| REAC:R-HSA-9701192 | 1.07318492464e-06 | 1.0 | RMI1 RMI2 TOP3A | Defective homologous recombination repair (HRR) due to BRCA1 loss of function |
| REAC:R-HSA-9701193 | 1.07318492464e-06 | 1.0 | RMI1 RMI2 TOP3A | Defective homologous recombination repair (HRR) due to PALB2 loss of function |
| REAC:R-HSA-5693554 | 1.36481126286e-06 | 1.0 | RMI1 RMI2 TOP3A | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) |
| GO:0071139 | 1.92240082153e-06 | 1.0 | RMI1 RMI2 TOP3A | resolution of DNA recombination intermediates |
| REAC:R-HSA-5693568 | 2.5457812821e-06 | 1.0 | RMI1 RMI2 TOP3A | Resolution of D-loop Structures through Holliday Junction Intermediates |
| REAC:R-HSA-5693537 | 2.79214721263e-06 | 1.0 | RMI1 RMI2 TOP3A | Resolution of D-Loop Structures |
| REAC:R-HSA-9709570 | 2.79214721263e-06 | 1.0 | RMI1 RMI2 TOP3A | Impaired BRCA2 binding to RAD51 |
| REAC:R-HSA-5685938 | 3.05391101381e-06 | 1.0 | RMI1 RMI2 TOP3A | HDR through Single Strand Annealing (SSA) |
| REAC:R-HSA-5693616 | 4.26427696795e-06 | 1.0 | RMI1 RMI2 TOP3A | Presynaptic phase of homologous DNA pairing and strand exchange |
| REAC:R-HSA-9701190 | 4.61002915454e-06 | 1.0 | RMI1 RMI2 TOP3A | Defective homologous recombination repair (HRR) due to BRCA2 loss of function |
| REAC:R-HSA-9675136 | 4.61002915454e-06 | 1.0 | RMI1 RMI2 TOP3A | Diseases of DNA Double-Strand Break Repair |
| REAC:R-HSA-5693579 | 5.35659258038e-06 | 1.0 | RMI1 RMI2 TOP3A | Homologous DNA Pairing and Strand Exchange |
| REAC:R-HSA-9675135 | 8.59667784851e-06 | 1.0 | RMI1 RMI2 TOP3A | Diseases of DNA repair |
| CORUM:246 | 2.05032700758e-05 | 0.666666666667 | TOP3A RMI1 | BLM complex III |
| REAC:R-HSA-5685942 | 2.13517139789e-05 | 1.0 | RMI1 RMI2 TOP3A | HDR through Homologous Recombination (HRR) |
| CORUM:2738 | 3.41705576683e-05 | 0.666666666667 | TOP3A RMI1 | BLM complex II |
| CORUM:2222 | 3.41705576683e-05 | 0.666666666667 | TOP3A RMI1 | BLM complex II |
| WP:WP5381 | 3.46946838589e-05 | 1.0 | RMI1 RMI2 TOP3A | Smith Magenis and Potocki Lupski syndrome copy number variation |
| REAC:R-HSA-69473 | 4.9457493951e-05 | 1.0 | RMI1 RMI2 TOP3A | G2/M DNA damage checkpoint |
| REAC:R-HSA-6804756 | 5.29892055573e-05 | 1.0 | RMI1 RMI2 TOP3A | Regulation of TP53 Activity through Phosphorylation |
| REAC:R-HSA-5693607 | 5.4816419542e-05 | 1.0 | RMI1 RMI2 TOP3A | Processing of DNA double-strand break ends |
| REAC:R-HSA-5693567 | 0.000141203606556 | 1.0 | RMI1 RMI2 TOP3A | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| CORUM:2739 | 0.0001537324292 | 0.666666666667 | TOP3A RMI1 | FA complex (Fanconi anemia complex) |
| REAC:R-HSA-5693538 | 0.00016307931474 | 1.0 | RMI1 RMI2 TOP3A | Homology Directed Repair |
| CORUM:244 | 0.000187886616059 | 0.666666666667 | TOP3A RMI1 | BRAFT complex |
| REAC:R-HSA-5633007 | 0.000267736308591 | 1.0 | RMI1 RMI2 TOP3A | Regulation of TP53 Activity |
| REAC:R-HSA-5693532 | 0.000300937850546 | 1.0 | RMI1 RMI2 TOP3A | DNA Double-Strand Break Repair |
| REAC:R-HSA-69481 | 0.000306725116903 | 1.0 | RMI1 RMI2 TOP3A | G2/M Checkpoints |
| REAC:R-HSA-69620 | 0.00167079914838 | 1.0 | RMI1 RMI2 TOP3A | Cell Cycle Checkpoints |
| REAC:R-HSA-73894 | 0.00220643087689 | 1.0 | RMI1 RMI2 TOP3A | DNA Repair |
| REAC:R-HSA-3700989 | 0.00297633187542 | 1.0 | RMI1 RMI2 TOP3A | Transcriptional Regulation by TP53 |
| WP:WP4016 | 0.0033030673862 | 0.666666666667 | TOP3A RMI1 | DNA IR damage and cellular response via ATR |
| REAC:R-HSA-1640170 | 0.0209648611427 | 1.0 | RMI1 RMI2 TOP3A | Cell Cycle |
| CORUM:2223 | 0.0499402709677 | 0.333333333333 | TOP3A | BLM-TOP3A complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RMI2 | TOP3A | 0.995 | 0.162 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| TOP3A | RMI1 | 0.994 | 0.346 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| RMI2 | RMI1 | 0.988 | 0.284 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| RMI2 | huMAP3_00733.1 huMAP3_01218.1 huMAP3_04213.1 huMAP3_07537.1 |
| TOP3A | huMAP3_00733.1 huMAP3_01218.1 huMAP3_04213.1 huMAP3_07537.1 |
| RMI1 | huMAP3_01218.1 huMAP3_04213.1 |