hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04223.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MFN2 | Mitofusin-2 (EC 3.6.5.-) (Transmembrane GTPase MFN2) | 5 | UniProt NCBI |
| MFN1 | Mitofusin-1 (EC 3.6.5.-) (Fzo homolog) (Transmembrane GTPase MFN1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9013419 | 3.58839967947e-05 | 1.0 | MFN2 MFN1 | RHOT2 GTPase cycle |
| REAC:R-HSA-9715370 | 4.78453290596e-05 | 1.0 | MFN2 MFN1 | Miro GTPase Cycle |
| REAC:R-HSA-5205685 | 0.000358839967947 | 1.0 | MFN2 MFN1 | PINK1-PRKN Mediated Mitophagy |
| REAC:R-HSA-5205647 | 0.000555347569442 | 1.0 | MFN2 MFN1 | Mitophagy |
| KEGG:04137 | 0.000772693757832 | 1.0 | MFN2 MFN1 | Mitophagy - animal |
| KEGG:04621 | 0.001720800216 | 1.0 | MFN2 MFN1 | NOD-like receptor signaling pathway |
| KEGG:05012 | 0.00458495309323 | 1.0 | MFN2 MFN1 | Parkinson disease |
| REAC:R-HSA-9663891 | 0.00474181386216 | 1.0 | MFN2 MFN1 | Selective autophagy |
| REAC:R-HSA-1632852 | 0.013456498798 | 1.0 | MFN2 MFN1 | Macroautophagy |
| KEGG:05022 | 0.0138982457502 | 1.0 | MFN2 MFN1 | Pathways of neurodegeneration - multiple diseases |
| REAC:R-HSA-9612973 | 0.0168654784935 | 1.0 | MFN2 MFN1 | Autophagy |
| REAC:R-HSA-983231 | 0.0209254964166 | 1.0 | MFN2 MFN1 | Factors involved in megakaryocyte development and platelet production |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| MFN1 | MFN2 | 0.994 | 0.286 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes