hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04225.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DYNC2LI1 | Cytoplasmic dynein 2 light intermediate chain 1 (Dynein 2 light intermediate chain) | 5 | UniProt NCBI |
| DYNC2H1 | Cytoplasmic dynein 2 heavy chain 1 (Cytoplasmic dynein 2 heavy chain) (Dynein cytoplasmic heavy chain 2) (Dynein heavy chain 11) (hDHC11) (Dynein heavy chain isotype 1B) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6236 | 0.000112778275641 | 1.0 | DYNC2LI1 DYNC2H1 | Dynein-2 complex, cytoplasmic |
| KEGG:04962 | 0.000126804361689 | 1.0 | DYNC2LI1 DYNC2H1 | Vasopressin-regulated water reabsorption |
| WP:WP4532 | 0.000149398593408 | 1.0 | DYNC2LI1 DYNC2H1 | Intraflagellar transport proteins binding to dynein |
| WP:WP5085 | 0.000331996874241 | 1.0 | DYNC2LI1 DYNC2H1 | Vasopressin regulated water reabsorption |
| HP:0000888 | 0.000358839967947 | 1.0 | DYNC2LI1 DYNC2H1 | Horizontal ribs |
| WP:WP4906 | 0.000679316681139 | 1.0 | DYNC2LI1 DYNC2H1 | 3q29 copy number variation syndrome |
| HP:0005483 | 0.000789447929484 | 1.0 | DYNC2LI1 DYNC2H1 | Abnormal epiglottis morphology |
| WP:WP5234 | 0.00121306550203 | 1.0 | DYNC2LI1 DYNC2H1 | Bardet Biedl syndrome |
| HP:0000090 | 0.00191723068589 | 1.0 | DYNC2LI1 DYNC2H1 | Nephronophthisis |
| WP:WP4536 | 0.00202305274778 | 1.0 | DYNC2LI1 DYNC2H1 | Genes related to primary cilium development based on CRISPR |
| KEGG:04814 | 0.00212007138563 | 1.0 | DYNC2LI1 DYNC2H1 | Motor proteins |
| REAC:R-HSA-5620924 | 0.00217867123396 | 1.0 | DYNC2LI1 DYNC2H1 | Intraflagellar transport |
| HP:0010306 | 0.00266566833332 | 1.0 | DYNC2LI1 DYNC2H1 | Short thorax |
| KEGG:05132 | 0.00406034068917 | 1.0 | DYNC2LI1 DYNC2H1 | Salmonella infection |
| HPA:0060873 | 0.00466395318849 | 1.0 | DYNC2LI1 DYNC2H1 | bronchus; ciliated cells (ciliary rootlets)[High] |
| HP:0100957 | 0.00489047613459 | 1.0 | DYNC2LI1 DYNC2H1 | Abnormal renal medulla morphology |
| WP:WP4803 | 0.00514595155073 | 1.0 | DYNC2LI1 DYNC2H1 | Ciliopathies |
| HP:0000773 | 0.00526298619656 | 1.0 | DYNC2LI1 DYNC2H1 | Short ribs |
| HP:0001830 | 0.00667442340382 | 1.0 | DYNC2LI1 DYNC2H1 | Postaxial foot polydactyly |
| HP:0010579 | 0.00825331926278 | 1.0 | DYNC2LI1 DYNC2H1 | Cone-shaped epiphysis |
| HPA:0320862 | 0.0095872823543 | 1.0 | DYNC2LI1 DYNC2H1 | nasopharynx; ciliated cells (cilia axoneme)[>=Medium] |
| HP:0002983 | 0.0107993742735 | 1.0 | DYNC2LI1 DYNC2H1 | Micromelia |
| HP:0010322 | 0.0110727761538 | 1.0 | DYNC2LI1 DYNC2H1 | Abnormal fifth toe morphology |
| HP:0001162 | 0.0110727761538 | 1.0 | DYNC2LI1 DYNC2H1 | Postaxial hand polydactyly |
| HP:0000112 | 0.0113495955576 | 1.0 | DYNC2LI1 DYNC2H1 | Nephropathy |
| HPA:0320861 | 0.0122171501522 | 1.0 | DYNC2LI1 DYNC2H1 | nasopharynx; ciliated cells (cilia axoneme)[>=Low] |
| HPA:0210873 | 0.0128309865718 | 1.0 | DYNC2LI1 DYNC2H1 | fallopian tube; ciliated cells (ciliary rootlets)[High] |
| HP:0008873 | 0.0146201655512 | 1.0 | DYNC2LI1 DYNC2H1 | Disproportionate short-limb short stature |
| HP:0000889 | 0.0146201655512 | 1.0 | DYNC2LI1 DYNC2H1 | Abnormal clavicle morphology |
| HP:0000142 | 0.0186596783332 | 1.0 | DYNC2LI1 DYNC2H1 | Abnormal vagina morphology |
| HPA:0320882 | 0.0188814879082 | 1.0 | DYNC2LI1 DYNC2H1 | nasopharynx; ciliated cells (tip of cilia)[>=Medium] |
| HP:0006712 | 0.0197464508076 | 1.0 | DYNC2LI1 DYNC2H1 | Aplasia/Hypoplasia of the ribs |
| HP:0000774 | 0.0201155433461 | 1.0 | DYNC2LI1 DYNC2H1 | Narrow chest |
| HPA:0060853 | 0.0215312151197 | 1.0 | DYNC2LI1 DYNC2H1 | bronchus; ciliated cells (cell body)[High] |
| HP:0003498 | 0.0220122688909 | 1.0 | DYNC2LI1 DYNC2H1 | Disproportionate short stature |
| HP:0001829 | 0.0231913144999 | 1.0 | DYNC2LI1 DYNC2H1 | Foot polydactyly |
| HP:0009136 | 0.0248112206409 | 1.0 | DYNC2LI1 DYNC2H1 | Duplication involving bones of the feet |
| HP:0001773 | 0.0252247409849 | 1.0 | DYNC2LI1 DYNC2H1 | Short foot |
| HPA:0320881 | 0.0259201455202 | 1.0 | DYNC2LI1 DYNC2H1 | nasopharynx; ciliated cells (tip of cilia)[>=Low] |
| HP:0100259 | 0.026912997596 | 1.0 | DYNC2LI1 DYNC2H1 | Postaxial polydactyly |
| HP:0005257 | 0.0282150740512 | 1.0 | DYNC2LI1 DYNC2H1 | Thoracic hypoplasia |
| REAC:R-HSA-5617833 | 0.0303578612883 | 1.0 | DYNC2LI1 DYNC2H1 | Cilium Assembly |
| HP:0006703 | 0.0304535519464 | 1.0 | DYNC2LI1 DYNC2H1 | Aplasia/Hypoplasia of the lungs |
| HP:0025423 | 0.0304535519464 | 1.0 | DYNC2LI1 DYNC2H1 | Abnormal larynx morphology |
| HPA:0060872 | 0.0332663231424 | 1.0 | DYNC2LI1 DYNC2H1 | bronchus; ciliated cells (ciliary rootlets)[>=Medium] |
| GO:0035721 | 0.0365196561665 | 1.0 | DYNC2LI1 DYNC2H1 | intraciliary retrograde transport |
| HP:0001161 | 0.0418509928331 | 1.0 | DYNC2LI1 DYNC2H1 | Hand polydactyly |
| HP:0002652 | 0.0423875440233 | 1.0 | DYNC2LI1 DYNC2H1 | Skeletal dysplasia |
| HP:0006711 | 0.042927512737 | 1.0 | DYNC2LI1 DYNC2H1 | Aplasia/Hypoplasia involving bones of the thorax |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| DYNC2LI1 | DYNC2H1 | 0.998 | 0.1 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM |
Related Complexes