hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04241.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PRDX4 | Peroxiredoxin-4 (EC 1.11.1.24) (Antioxidant enzyme AOE372) (AOE37-2) (Peroxiredoxin IV) (Prx-IV) (Thioredoxin peroxidase AO372) (Thioredoxin-dependent peroxide reductase A0372) (Thioredoxin-dependent peroxiredoxin 4) | 5 | UniProt NCBI |
| PRDX1 | Peroxiredoxin-1 (EC 1.11.1.24) (Natural killer cell-enhancing factor A) (NKEF-A) (Proliferation-associated gene protein) (PAG) (Thioredoxin peroxidase 2) (Thioredoxin-dependent peroxide reductase 2) (Thioredoxin-dependent peroxiredoxin 1) | 5 | UniProt NCBI |
| PRDX2 | Peroxiredoxin-2 (EC 1.11.1.24) (Natural killer cell-enhancing factor B) (NKEF-B) (PRP) (Thiol-specific antioxidant protein) (TSA) (Thioredoxin peroxidase 1) (Thioredoxin-dependent peroxide reductase 1) (Thioredoxin-dependent peroxiredoxin 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0008379 | 3.84480164306e-07 | 1.0 | PRDX1 PRDX4 PRDX2 | thioredoxin peroxidase activity |
| GO:0051920 | 3.84480164306e-07 | 1.0 | PRDX1 PRDX4 PRDX2 | peroxiredoxin activity |
| GO:0140824 | 3.84480164306e-07 | 1.0 | PRDX1 PRDX4 PRDX2 | thioredoxin-dependent peroxiredoxin activity |
| WP:WP15 | 3.88479998273e-06 | 1.0 | PRDX1 PRDX4 PRDX2 | Selenium micronutrient network |
| GO:0042744 | 0.000170228592746 | 1.0 | PRDX1 PRDX4 PRDX2 | hydrogen peroxide catabolic process |
| GO:0045454 | 0.000575182325801 | 1.0 | PRDX1 PRDX4 PRDX2 | cell redox homeostasis |
| GO:0042743 | 0.000746852719164 | 1.0 | PRDX1 PRDX4 PRDX2 | hydrogen peroxide metabolic process |
| GO:0004601 | 0.00118621742692 | 1.0 | PRDX1 PRDX4 PRDX2 | peroxidase activity |
| GO:0016684 | 0.00136394338287 | 1.0 | PRDX1 PRDX4 PRDX2 | oxidoreductase activity, acting on peroxide as acceptor |
| REAC:R-HSA-8862803 | 0.00143063482691 | 0.666666666667 | PRDX1 PRDX2 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
| REAC:R-HSA-8863678 | 0.00143063482691 | 0.666666666667 | PRDX1 PRDX2 | Neurodegenerative Diseases |
| REAC:R-HSA-9734009 | 0.00188000535098 | 0.666666666667 | PRDX1 PRDX2 | Defective Intrinsic Pathway for Apoptosis |
| REAC:R-HSA-3299685 | 0.00257431960226 | 0.666666666667 | PRDX1 PRDX2 | Detoxification of Reactive Oxygen Species |
| GO:0016209 | 0.00419852339422 | 1.0 | PRDX1 PRDX4 PRDX2 | antioxidant activity |
| REAC:R-HSA-5628897 | 0.0209338694285 | 0.666666666667 | PRDX1 PRDX2 | TP53 Regulates Metabolic Genes |
| REAC:R-HSA-9645723 | 0.0278082114556 | 0.666666666667 | PRDX1 PRDX2 | Diseases of programmed cell death |
| GO:0072593 | 0.0411908979227 | 1.0 | PRDX1 PRDX4 PRDX2 | reactive oxygen species metabolic process |
| WP:WP4873 | 0.0496447587094 | 0.333333333333 | PRDX2 | Peroxiredoxin 2 induced ovarian failure |
| CORUM:6675 | 0.0499402709677 | 0.333333333333 | PRDX1 | PI4K2A-PRDX1 complex |
| CORUM:3151 | 0.0499402709677 | 0.333333333333 | PRDX1 | Sulphiredoxin-peroxiredoxin complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PRDX1 | PRDX2 | 0.994 | 0.482 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt hein () Malo bioplex3_HCT116 fraction boldt_WMM treiber_WMM |
| PRDX4 | PRDX1 | 0.976 | 0.258 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt boldt_WMM treiber_WMM WMM_only |
| PRDX4 | PRDX2 | 0.12 | 0.194 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM WMM_only |
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