hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04256.1
Complex Portal: CPX-23414
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MPDZ | Multiple PDZ domain protein (Multi-PDZ domain protein 1) | 5 | UniProt NCBI |
| AMOTL2 | Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP) | 5 | UniProt NCBI |
| AMOT | Angiomotin | 5 | UniProt NCBI |
| PALS1 | Protein PALS1 (MAGUK p55 subfamily member 5) (Membrane protein, palmitoylated 5) (Protein associated with Lin-7 1) | 5 | UniProt NCBI |
| CRB3 | Protein crumbs homolog 3 | 5 | UniProt NCBI |
| AMOTL1 | Angiomotin-like protein 1 | 5 | UniProt NCBI |
| YAP1 | Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:848 | 2.20992482997e-14 | 0.714285714286 | MPDZ AMOTL1 PALS1 AMOT AMOTL2 | RICH1/AMOT polarity complex, Flag-Amot precipitated |
| KEGG:04530 | 2.4073823255e-10 | 0.857142857143 | MPDZ AMOT AMOTL1 PALS1 AMOTL2 CRB3 | Tight junction |
| GO:0043296 | 7.74476915066e-09 | 0.857142857143 | MPDZ AMOT AMOTL1 PALS1 AMOTL2 CRB3 | apical junction complex |
| GO:0005911 | 7.86865937855e-08 | 1.0 | MPDZ AMOT AMOTL1 PALS1 AMOTL2 CRB3 YAP1 | cell-cell junction |
| GO:0003365 | 3.36420143768e-06 | 0.428571428571 | AMOTL2 AMOT AMOTL1 | establishment of cell polarity involved in ameboidal cell migration |
| GO:0070161 | 1.11756958291e-05 | 1.0 | MPDZ AMOT AMOTL1 PALS1 AMOTL2 CRB3 YAP1 | anchoring junction |
| REAC:R-HSA-2028269 | 1.25938591632e-05 | 0.428571428571 | AMOTL2 YAP1 AMOTL1 | Signaling by Hippo |
| GO:0035329 | 0.000102438985779 | 0.571428571429 | AMOTL2 YAP1 AMOT AMOTL1 | hippo signaling |
| GO:0007163 | 0.00013411944099 | 0.714285714286 | CRB3 AMOTL2 AMOTL1 AMOT PALS1 | establishment or maintenance of cell polarity |
| REAC:R-HSA-9705677 | 0.000380832872101 | 0.285714285714 | PALS1 CRB3 | SARS-CoV-2 targets PDZ proteins in cell-cell junction |
| GO:0005923 | 0.000387272795324 | 0.571428571429 | MPDZ AMOTL1 AMOT AMOTL2 | bicellular tight junction |
| CORUM:846 | 0.000573957048441 | 0.285714285714 | PALS1 AMOT | RICH1/AMOT polarity complex, Flag-Rich1 precipitated |
| GO:0070160 | 0.000835286748042 | 0.571428571429 | MPDZ AMOTL1 AMOT AMOTL2 | tight junction |
| GO:0030054 | 0.000952363989281 | 1.0 | MPDZ AMOT AMOTL1 PALS1 AMOTL2 CRB3 YAP1 | cell junction |
| KEGG:04390 | 0.00173244468583 | 0.428571428571 | PALS1 AMOT YAP1 | Hippo signaling pathway |
| REAC:R-HSA-420029 | 0.00398963152505 | 0.285714285714 | PALS1 CRB3 | Tight junction interactions |
| REAC:R-HSA-421270 | 0.037359797124 | 0.285714285714 | PALS1 CRB3 | Cell-cell junction organization |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PALS1 | AMOTL1 | 0.999 | 0.094 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| CRB3 | PALS1 | 0.999 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| AMOTL2 | PALS1 | 0.999 | 0.04 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| YAP1 | AMOTL1 | 0.998 | 0.064 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| AMOTL2 | YAP1 | 0.997 | 0.068 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| PALS1 | MPDZ | 0.996 | 0.052 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM fraction |
| YAP1 | AMOT | 0.996 | 0.122 | hein_WMM bioplex_WMM bioplex3_WMM boldt hein () boldt_WMM | |
| YAP1 | PALS1 | 0.995 | 0.08 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () | |
| AMOT | AMOTL1 | 0.995 | 0.128 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM hein () boldt_WMM | |
| MPDZ | AMOTL1 | 0.991 | 0.078 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| AMOTL2 | MPDZ | 0.987 | 0.07 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| YAP1 | MPDZ | 0.984 | 0.022 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () | |
| AMOT | MPDZ | 0.983 | 0.0822222222222 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| AMOTL2 | AMOTL1 | 0.976 | 0.092 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| PALS1 | AMOT | 0.973 | 0.076 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM | |
| CRB3 | AMOTL1 | 0.611 |
mutually_exclusive (Q8N3R9)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| AMOTL2 | CRB3 | 0.603 |
mutually_exclusive (Q8N3R9)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| CRB3 | MPDZ | 0.303 |
structurally_consistent (Q8N3R9)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| AMOTL2 | AMOT | 0.268 | 0.206 | bioplex_WMM bioplex3_WMM WMM_only | |
| CRB3 | AMOT | 0.173 | bioplex_WMM bioplex3_WMM WMM_only | ||
| YAP1 | CRB3 | 0.05 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes