hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04265.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PLPP2 | Phospholipid phosphatase 2 (EC 3.1.3.-) (EC 3.1.3.4) (Lipid phosphate phosphohydrolase 2) (PAP2-gamma) (PAP2-G) (Phosphatidate phosphohydrolase type 2c) (Phosphatidic acid phosphatase 2c) (PAP-2c) (PAP2c) | 5 | UniProt NCBI |
| PLPP1 | Phospholipid phosphatase 1 (EC 3.1.3.-) (EC 3.1.3.106) (EC 3.1.3.4) (EC 3.6.1.75) (Lipid phosphate phosphohydrolase 1) (PAP2-alpha) (Phosphatidate phosphohydrolase type 2a) (Phosphatidic acid phosphatase 2a) (PAP-2a) (PAP2a) | 5 | UniProt NCBI |
| PLPP3 | Phospholipid phosphatase 3 (EC 3.1.3.-) (EC 3.1.3.4) (Lipid phosphate phosphohydrolase 3) (PAP2-beta) (Phosphatidate phosphohydrolase type 2b) (Phosphatidic acid phosphatase 2b) (PAP-2b) (PAP2b) (Vascular endothelial growth factor and type I collagen-inducible protein) (VCIP) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0106235 | 9.61200410764e-08 | 1.0 | PLPP2 PLPP1 PLPP3 | ceramide-1-phosphate phosphatase activity |
| WP:WP325 | 1.19374889724e-07 | 1.0 | PLPP2 PLPP1 PLPP3 | Triacylglyceride synthesis |
| WP:WP4726 | 1.37281123183e-07 | 1.0 | PLPP2 PLPP1 PLPP3 | Sphingolipid metabolism integrated pathway |
| KEGG:04975 | 2.12090960201e-07 | 1.0 | PLPP2 PLPP1 PLPP3 | Fat digestion and absorption |
| KEGG:00565 | 4.05898216937e-07 | 1.0 | PLPP2 PLPP1 PLPP3 | Ether lipid metabolism |
| KEGG:00600 | 8.47057861986e-07 | 1.0 | PLPP2 PLPP1 PLPP3 | Sphingolipid metabolism |
| KEGG:00561 | 1.22375439253e-06 | 1.0 | PLPP2 PLPP1 PLPP3 | Glycerolipid metabolism |
| GO:0042392 | 1.92240082153e-06 | 1.0 | PLPP2 PLPP1 PLPP3 | sphingosine-1-phosphate phosphatase activity |
| REAC:R-HSA-1660661 | 2.79214721263e-06 | 1.0 | PLPP2 PLPP1 PLPP3 | Sphingolipid de novo biosynthesis |
| KEGG:00564 | 4.13101996102e-06 | 1.0 | PLPP2 PLPP1 PLPP3 | Glycerophospholipid metabolism |
| KEGG:05231 | 4.79978559464e-06 | 1.0 | PLPP2 PLPP1 PLPP3 | Choline metabolism in cancer |
| KEGG:04666 | 6.13705566612e-06 | 1.0 | PLPP2 PLPP1 PLPP3 | Fc gamma R-mediated phagocytosis |
| KEGG:04072 | 1.32405356583e-05 | 1.0 | PLPP2 PLPP1 PLPP3 | Phospholipase D signaling pathway |
| GO:0008195 | 2.11464090368e-05 | 1.0 | PLPP2 PLPP1 PLPP3 | phosphatidate phosphatase activity |
| REAC:R-HSA-428157 | 2.90207867708e-05 | 1.0 | PLPP2 PLPP1 PLPP3 | Sphingolipid metabolism |
| GO:0006670 | 3.49876949518e-05 | 1.0 | PLPP2 PLPP1 PLPP3 | sphingosine metabolic process |
| GO:0046519 | 4.37346186898e-05 | 1.0 | PLPP2 PLPP1 PLPP3 | sphingoid metabolic process |
| GO:0042577 | 5.38272230028e-05 | 1.0 | PLPP2 PLPP1 PLPP3 | lipid phosphatase activity |
| GO:0034311 | 9.31403198031e-05 | 1.0 | PLPP2 PLPP1 PLPP3 | diol metabolic process |
| GO:0046839 | 0.000476755403739 | 1.0 | PLPP2 PLPP1 PLPP3 | phospholipid dephosphorylation |
| GO:0019751 | 0.00381702295119 | 1.0 | PLPP2 PLPP1 PLPP3 | polyol metabolic process |
| GO:0006672 | 0.00820096190464 | 1.0 | PLPP2 PLPP1 PLPP3 | ceramide metabolic process |
| GO:0030148 | 0.0105478288276 | 1.0 | PLPP2 PLPP1 PLPP3 | sphingolipid biosynthetic process |
| REAC:R-HSA-556833 | 0.0177385429708 | 1.0 | PLPP2 PLPP1 PLPP3 | Metabolism of lipids |
| KEGG:01100 | 0.0189521995452 | 1.0 | PLPP2 PLPP1 PLPP3 | Metabolic pathways |
| GO:0046467 | 0.0250037062852 | 1.0 | PLPP2 PLPP1 PLPP3 | membrane lipid biosynthetic process |
| GO:0006665 | 0.0269943523359 | 1.0 | PLPP2 PLPP1 PLPP3 | sphingolipid metabolic process |
| GO:0030258 | 0.0402954436201 | 1.0 | PLPP2 PLPP1 PLPP3 | lipid modification |
| CORUM:2366 | 0.0499402709677 | 0.333333333333 | PLPP3 | ITGAV-ITGB3-PPAP2b complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PLPP2 | PLPP3 | 0.999 | 0.116 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| PLPP1 | PLPP2 | 0.984 | 0.114 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| PLPP1 | PLPP3 | 0.904 | 0.15 | bioplex3_WMM WMM_only |
Related Complexes