hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04276.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RABGGTB | Geranylgeranyl transferase type-2 subunit beta (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit beta) (GGTase-II-beta) (Rab geranyl-geranyltransferase subunit beta) (Rab GG transferase beta) (Rab GGTase beta) (Rab geranylgeranyltransferase subunit beta) (Type II protein geranyl-geranyltransferase subunit beta) | 5 | UniProt NCBI |
| PPP1R16A | Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase-targeting subunit 3) | 5 | UniProt NCBI |
| RABGGTA | Geranylgeranyl transferase type-2 subunit alpha (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit alpha) (Rab geranyl-geranyltransferase subunit alpha) (Rab GG transferase alpha) (Rab GGTase alpha) (Rab geranylgeranyltransferase subunit alpha) | 5 | UniProt NCBI |
| INPP5A | Inositol polyphosphate-5-phosphatase A (EC 3.1.3.56) (43 kDa inositol polyphosphate 5-phosphatase) (Type I inositol 1,4,5-trisphosphate 5-phosphatase) (5PTase) | 5 | UniProt NCBI |
| PGBD5 | PiggyBac transposable element-derived protein 5 (EC 3.1.-.-) (PiggyBac domain-related protein 5) (PiggyBac transposase 5) | 5 | UniProt NCBI |
| RAB7B | Ras-related protein Rab-7b | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8873719 | 0.000264877822759 | 0.5 | RAB7B RABGGTB RABGGTA | RAB geranylgeranylation |
| REAC:R-HSA-6803205 | 0.00200991204249 | 0.333333333333 | RABGGTB RABGGTA | TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain |
| REAC:R-HSA-5633008 | 0.0180324600743 | 0.333333333333 | RABGGTB RABGGTA | TP53 Regulates Transcription of Cell Death Genes |
| GO:0004663 | 0.0210651876021 | 0.333333333333 | RABGGTB RABGGTA | Rab geranylgeranyltransferase activity |
| GO:0005968 | 0.042122686785 | 0.333333333333 | RABGGTB RABGGTA | Rab-protein geranylgeranyltransferase complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RABGGTB | RABGGTA | 1.0 | 0.182 | bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM bioplex3_HCT116 fraction |
| RABGGTB | INPP5A | 0.998 | 0.06 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RABGGTA | RAB7B | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RABGGTB | RAB7B | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PPP1R16A | RABGGTA | 0.996 | 0.064 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RABGGTB | PPP1R16A | 0.988 | 0.06 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| RABGGTA | INPP5A | 0.979 | 0.05 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RABGGTB | PGBD5 | 0.967 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PPP1R16A | INPP5A | 0.961 | 0.146 | bioplex_WMM bioplex3_WMM WMM_only |
| PPP1R16A | PGBD5 | 0.513 | bioplex_WMM bioplex3_WMM WMM_only | |
| INPP5A | PGBD5 | 0.363 | bioplex_WMM bioplex3_WMM WMM_only | |
| RABGGTA | PGBD5 | 0.217 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes