hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_04277.1

Complex Portal: CPX-23539

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
PFKL	ATP-dependent 6-phosphofructokinase, liver type (ATP-PFK) (PFK-L) (EC 2.7.1.11) (6-phosphofructokinase type B) (Phosphofructo-1-kinase isozyme B) (PFK-B) (Phosphohexokinase)	5	UniProt NCBI
PFKM	ATP-dependent 6-phosphofructokinase, muscle type (ATP-PFK) (PFK-M) (EC 2.7.1.11) (6-phosphofructokinase type A) (Phosphofructo-1-kinase isozyme A) (PFK-A) (Phosphohexokinase)	5	UniProt NCBI
PFKP	ATP-dependent 6-phosphofructokinase, platelet type (ATP-PFK) (PFK-P) (EC 2.7.1.11) (6-phosphofructokinase type C) (Phosphofructo-1-kinase isozyme C) (PFK-C) (Phosphohexokinase)	5	UniProt NCBI
ABCF2	ATP-binding cassette sub-family F member 2 (Iron-inhibited ABC transporter 2)	3	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0003872	3.84480164306e-07	0.75	PFKM PFKL PFKP	6-phosphofructokinase activity
GO:0070095	3.84480164306e-07	0.75	PFKM PFKL PFKP	fructose-6-phosphate binding
GO:0005945	3.84480164306e-07	0.75	PFKM PFKL PFKP	6-phosphofructokinase complex
KEGG:00052	8.91489558656e-07	0.75	PFKM PFKL PFKP	Galactose metabolism
KEGG:00030	1.0028742148e-06	0.75	PFKM PFKL PFKP	Pentose phosphate pathway
KEGG:00051	2.05095399953e-06	0.75	PFKM PFKL PFKP	Fructose and mannose metabolism
WP:WP534	4.00454251624e-06	0.75	PFKM PFKL PFKP	Glycolysis and gluconeogenesis
KEGG:00010	1.2943754201e-05	0.75	PFKM PFKL PFKP	Glycolysis / Gluconeogenesis
GO:0008443	1.34540429244e-05	0.75	PFKM PFKL PFKP	phosphofructokinase activity
KEGG:05230	1.63910874597e-05	0.75	PFKM PFKL PFKP	Central carbon metabolism in cancer
KEGG:01230	1.63910874597e-05	0.75	PFKM PFKL PFKP	Biosynthesis of amino acids
KEGG:03018	2.12742945788e-05	0.75	PFKM PFKL PFKP	RNA degradation
WP:WP4018	2.35146163933e-05	0.75	PFKM PFKL PFKP	Clear cell renal cell carcinoma pathways
GO:0030388	3.22863876272e-05	0.75	PFKM PFKL PFKP	fructose 1,6-bisphosphate metabolic process
WP:WP5355	3.5618246416e-05	0.75	PFKM PFKL PFKP	Metabolic Epileptic Disorders
KEGG:04922	4.29129056473e-05	0.75	PFKM PFKL PFKP	Glucagon signaling pathway
GO:0006002	4.61210427592e-05	0.75	PFKM PFKL PFKP	fructose 6-phosphate metabolic process
KEGG:04066	5.35787298046e-05	0.75	PFKM PFKL PFKP	HIF-1 signaling pathway
REAC:R-HSA-70171	6.1097260824e-05	0.75	PFKM PFKL PFKP	Glycolysis
KEGG:01200	6.21896513057e-05	0.75	PFKM PFKL PFKP	Carbon metabolism
GO:0016208	6.34131776058e-05	0.75	PFKM PFKL PFKP	AMP binding
KEGG:04919	6.40154556396e-05	0.75	PFKM PFKL PFKP	Thyroid hormone signaling pathway
KEGG:04152	7.99217742683e-05	0.75	PFKM PFKL PFKP	AMPK signaling pathway
REAC:R-HSA-70326	0.000110531761496	0.75	PFKM PFKL PFKP	Glucose metabolism
GO:0061718	0.000215165225046	0.75	PFKM PFKL PFKP	glucose catabolic process to pyruvate
GO:0061621	0.000215165225046	0.75	PFKM PFKL PFKP	canonical glycolysis
GO:0006735	0.000215165225046	0.75	PFKM PFKL PFKP	NADH regeneration
GO:0061615	0.000261258639543	0.75	PFKM PFKL PFKP	glycolytic process through fructose-6-phosphate
GO:0061620	0.000261258639543	0.75	PFKM PFKL PFKP	glycolytic process through glucose-6-phosphate
GO:0019677	0.000313494264121	0.75	PFKM PFKL PFKP	NAD catabolic process
GO:0006007	0.000372255315939	0.75	PFKM PFKL PFKP	glucose catabolic process
GO:0019200	0.000437924933217	0.75	PFKM PFKL PFKP	carbohydrate kinase activity
CORUM:1335	0.000537621686958	0.5	PFKL ABCF2	SNW1 complex
GO:0006734	0.000883305813556	0.75	PFKM PFKL PFKP	NADH metabolic process
GO:0019320	0.00140301566648	0.75	PFKM PFKL PFKP	hexose catabolic process
GO:0046365	0.00172575455775	0.75	PFKM PFKL PFKP	monosaccharide catabolic process
GO:0048029	0.00229706847948	0.75	PFKM PFKL PFKP	monosaccharide binding
REAC:R-HSA-71387	0.00382744839761	0.75	PFKM PFKL PFKP	Metabolism of carbohydrates
GO:0005524	0.00404764913615	1.0	ABCF2 PFKM PFKL PFKP	ATP binding
GO:0019674	0.00582352741409	0.75	PFKM PFKL PFKP	NAD metabolic process
GO:0032559	0.00780772871207	1.0	ABCF2 PFKM PFKL PFKP	adenyl ribonucleotide binding
GO:0030554	0.0165461243948	1.0	ABCF2 PFKM PFKL PFKP	adenyl nucleotide binding
GO:0006096	0.0167406494658	0.75	PFKM PFKL PFKP	glycolytic process
GO:0046032	0.0167406494658	0.75	PFKM PFKL PFKP	ADP catabolic process
GO:0046031	0.0175369202004	0.75	PFKM PFKL PFKP	ADP metabolic process
GO:0009181	0.0183580179548	0.75	PFKM PFKL PFKP	purine ribonucleoside diphosphate catabolic process
GO:0009137	0.0183580179548	0.75	PFKM PFKL PFKP	purine nucleoside diphosphate catabolic process
GO:0019364	0.0192043220783	0.75	PFKM PFKL PFKP	pyridine nucleotide catabolic process
GO:0009179	0.0192043220783	0.75	PFKM PFKL PFKP	purine ribonucleoside diphosphate metabolic process
GO:0009135	0.0200762118412	0.75	PFKM PFKL PFKP	purine nucleoside diphosphate metabolic process
GO:0009191	0.0209740664347	0.75	PFKM PFKL PFKP	ribonucleoside diphosphate catabolic process
GO:0072526	0.0218982649712	0.75	PFKM PFKL PFKP	pyridine-containing compound catabolic process
GO:0009134	0.0228491864842	0.75	PFKM PFKL PFKP	nucleoside diphosphate catabolic process
WP:WP481	0.0255965717397	0.5	PFKM PFKL	Insulin signaling
GO:0009185	0.0269276802074	0.75	PFKM PFKL PFKP	ribonucleoside diphosphate metabolic process
GO:0009132	0.0314640437065	0.75	PFKM PFKL PFKP	nucleoside diphosphate metabolic process
GO:0035639	0.0326761482103	1.0	ABCF2 PFKM PFKL PFKP	purine ribonucleoside triphosphate binding
GO:0030246	0.0364824972322	0.75	PFKM PFKL PFKP	carbohydrate binding
GO:0006090	0.0420072408269	0.75	PFKM PFKL PFKP	pyruvate metabolic process
GO:0070061	0.042122686785	0.5	PFKM PFKL	fructose binding
GO:0009154	0.048062454325	0.75	PFKM PFKL PFKP	purine ribonucleotide catabolic process

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
PFKL	PFKP	0.999	0.312	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM
PFKM	PFKL	0.985	0.136	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM Malo gupta_WMM fraction treiber_WMM
PFKM	PFKP	0.97	0.322	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM treiber_WMM
PFKP	ABCF2	0.97	0.164	hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
PFKL	ABCF2	0.958	0.032	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM treiber_WMM
PFKM	ABCF2	0.712	0.106	bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only treiber_WMM

Related Complexes

Genename	Complexes
PFKL	huMAP3_04277.1 huMAP3_06522.1 huMAP3_07672.1 huMAP3_09007.1 huMAP3_09189.1 huMAP3_09824.1
PFKM	huMAP3_02135.1 huMAP3_04277.1 huMAP3_04695.1 huMAP3_09436.1 huMAP3_09730.1 huMAP3_09750.1 huMAP3_10153.1
PFKP	huMAP3_04277.1
ABCF2	huMAP3_04277.1 huMAP3_06981.1 huMAP3_08152.1 huMAP3_09056.1 huMAP3_11037.1 huMAP3_11129.1 huMAP3_12301.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_04277.1

Complex Portal: CPX-23539