hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04280.1
Complex Portal: CPX-20695
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CFAP74 | Cilia- and flagella-associated protein 74 | 5 | UniProt NCBI |
| RNF34 | E3 ubiquitin-protein ligase RNF34 (EC 2.3.2.27) (Caspase regulator CARP1) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (RING finger protein 34) (RING finger protein RIFF) (RING-type E3 ubiquitin transferase RNF34) | 5 | UniProt NCBI |
| PDE9A | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35) | 5 | UniProt NCBI |
| PALD1 | Paladin | 4 | UniProt NCBI |
| UNC119 | Protein unc-119 homolog A (Retinal protein 4) (hRG4) | 5 | UniProt NCBI |
| UNC119B | Protein unc-119 homolog B | 5 | UniProt NCBI |
| PRKG2 | cGMP-dependent protein kinase 2 (cGK 2) (cGK2) (EC 2.7.11.12) (cGMP-dependent protein kinase II) (cGKII) | 5 | UniProt NCBI |
| RSPRY1 | RING finger and SPRY domain-containing protein 1 | 4 | UniProt NCBI |
| CYS1 | Cystin-1 (Cilia-associated protein) | 4 | UniProt NCBI |
| PSKH2 | Serine/threonine-protein kinase H2 (EC 2.7.11.1) (Protein serine kinase H2) (PSK-H2) | 5 | UniProt NCBI |
| LZTS1 | Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer-related gene-coding leucine-zipper motif) (Fez1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5624138 | 0.00133260792819 | 0.181818181818 | UNC119B CYS1 | Trafficking of myristoylated proteins to the cilium |
| HP:0004592 | 0.00714132578593 | 0.181818181818 | PRKG2 RSPRY1 | Thoracic platyspondyly |
| REAC:R-HSA-418457 | 0.00876996466453 | 0.181818181818 | PRKG2 PDE9A | cGMP effects |
| REAC:R-HSA-392154 | 0.0180343727667 | 0.181818181818 | PRKG2 PDE9A | Nitric oxide stimulates guanylate cyclase |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| UNC119 | UNC119B | 1.0 | 0.32 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM |
| PALD1 | UNC119 | 0.999 | 0.066 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM | |
| PDE9A | UNC119 | 0.999 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM | |
| UNC119 | LZTS1 | 0.998 | 0.036 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| UNC119 | PSKH2 | 0.998 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PALD1 | UNC119B | 0.997 | 0.014 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| PSKH2 | UNC119B | 0.997 |
structurally_consistent (Q13432)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RNF34 | UNC119 | 0.996 | 0.072 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM |
| RNF34 | UNC119B | 0.995 | 0.038 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CYS1 | UNC119B | 0.994 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| UNC119 | CYS1 | 0.985 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| UNC119 | RSPRY1 | 0.977 | 0.122 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM | |
| RSPRY1 | UNC119B | 0.977 | 0.068 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| UNC119 | PRKG2 | 0.966 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM | ||
| UNC119B | LZTS1 | 0.955 | 0.04 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| PDE9A | PALD1 | 0.918 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | ||
| PDE9A | LZTS1 | 0.916 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PDE9A | RSPRY1 | 0.693 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | ||
| PDE9A | PRKG2 | 0.65 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | ||
| PDE9A | UNC119B | 0.605 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PALD1 | LZTS1 | 0.582 | 0.072 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| PRKG2 | LZTS1 | 0.572 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PALD1 | PRKG2 | 0.495 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | ||
| PALD1 | RSPRY1 | 0.468 | 0.036 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| RNF34 | PDE9A | 0.46 |
structurally_consistent (Q13432)
|
bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| RNF34 | PRKG2 | 0.45 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | ||
| RSPRY1 | LZTS1 | 0.408 | 0.118 | bioplex_WMM bioplex3_WMM WMM_only | |
| RNF34 | PALD1 | 0.216 | 0.042 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| PRKG2 | RSPRY1 | 0.201 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | ||
| RNF34 | LZTS1 | 0.172 | 0.074 | bioplex_WMM bioplex3_WMM WMM_only | |
| PRKG2 | UNC119B | 0.165 | bioplex_WMM bioplex3_WMM WMM_only | ||
| RSPRY1 | CFAP74 | 0.063 | bioplex3_WMM WMM_only | ||
| RNF34 | RSPRY1 | 0.051 | 0.128 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
Related Complexes