hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_04291.1
Complex Portal: CPX-22676
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ATXN7L1 | Ataxin-7-like protein 1 (Ataxin-7-like protein 4) | 4 | UniProt NCBI |
| ENY2 | Transcription and mRNA export factor ENY2 (Enhancer of yellow 2 transcription factor homolog) | 5 | UniProt NCBI |
| TADA2B | Transcriptional adapter 2-beta (ADA2-like protein beta) (ADA2-beta) | 5 | UniProt NCBI |
| SUPT20H | Transcription factor SPT20 homolog (p38-interacting protein) (p38IP) | 5 | UniProt NCBI |
| TAF5L | TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L (TAF5L) (PCAF-associated factor 65 beta) (PAF65-beta) | 5 | UniProt NCBI |
| USP22 | Ubiquitin carboxyl-terminal hydrolase 22 (EC 3.4.19.12) (Deubiquitinating enzyme 22) (Ubiquitin thioesterase 22) (Ubiquitin-specific-processing protease 22) | 5 | UniProt NCBI |
| ATXN7L3 | Ataxin-7-like protein 3 (SAGA-associated factor 11 homolog) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6664 | 1.46510357715e-15 | 0.857142857143 | TADA2B USP22 ATXN7L3 ENY2 TAF5L SUPT20H | STAGA complex, SPT3-linked |
| CORUM:6643 | 1.46510357715e-15 | 0.857142857143 | TADA2B ATXN7L1 USP22 ATXN7L3 TAF5L SUPT20H | SAGA complex, GCN5-linked |
| GO:0000124 | 1.40340440006e-12 | 0.857142857143 | TADA2B USP22 ATXN7L3 ENY2 TAF5L SUPT20H | SAGA complex |
| GO:0070461 | 5.03304585028e-11 | 0.857142857143 | TADA2B USP22 ATXN7L3 ENY2 TAF5L SUPT20H | SAGA-type complex |
| REAC:R-HSA-3214847 | 5.66580110048e-10 | 0.857142857143 | TADA2B USP22 ATXN7L3 ENY2 TAF5L SUPT20H | HATs acetylate histones |
| GO:0000123 | 1.3960568699e-08 | 0.857142857143 | TADA2B USP22 ATXN7L3 ENY2 TAF5L SUPT20H | histone acetyltransferase complex |
| GO:0031248 | 2.71002790433e-08 | 0.857142857143 | TADA2B USP22 ATXN7L3 ENY2 TAF5L SUPT20H | protein acetyltransferase complex |
| GO:1902493 | 2.71002790433e-08 | 0.857142857143 | TADA2B USP22 ATXN7L3 ENY2 TAF5L SUPT20H | acetyltransferase complex |
| GO:1905368 | 3.06864686558e-08 | 0.857142857143 | TADA2B USP22 ATXN7L3 ENY2 TAF5L SUPT20H | peptidase complex |
| REAC:R-HSA-3247509 | 3.1566620346e-08 | 0.857142857143 | TADA2B USP22 ATXN7L3 ENY2 TAF5L SUPT20H | Chromatin modifying enzymes |
| REAC:R-HSA-4839726 | 3.1566620346e-08 | 0.857142857143 | TADA2B USP22 ATXN7L3 ENY2 TAF5L SUPT20H | Chromatin organization |
| CORUM:6641 | 3.92905941962e-07 | 0.428571428571 | TADA2B USP22 ATXN7L3 | USP22-SAGA complex |
| GO:0043484 | 4.65983809141e-07 | 0.857142857143 | TADA2B USP22 ATXN7L3 ENY2 TAF5L SUPT20H | regulation of RNA splicing |
| GO:0006282 | 1.86567783047e-06 | 0.857142857143 | TADA2B USP22 ATXN7L3 ENY2 TAF5L SUPT20H | regulation of DNA repair |
| GO:0033276 | 2.81160701714e-06 | 0.571428571429 | TAF5L ENY2 ATXN7L3 USP22 | transcription factor TFTC complex |
| GO:0008380 | 8.11796570198e-05 | 0.857142857143 | TADA2B USP22 ATXN7L3 ENY2 TAF5L SUPT20H | RNA splicing |
| GO:0080135 | 0.000130410250953 | 0.857142857143 | TADA2B USP22 ATXN7L3 ENY2 TAF5L SUPT20H | regulation of cellular response to stress |
| GO:0051052 | 0.000175378698208 | 0.857142857143 | TADA2B USP22 ATXN7L3 ENY2 TAF5L SUPT20H | regulation of DNA metabolic process |
| GO:0003712 | 0.000177928273763 | 0.857142857143 | TADA2B USP22 ATXN7L3 ENY2 TAF5L SUPT20H | transcription coregulator activity |
| GO:0006281 | 0.000435439962474 | 0.857142857143 | TADA2B USP22 ATXN7L3 ENY2 TAF5L SUPT20H | DNA repair |
| GO:0016591 | 0.000742145232605 | 0.571428571429 | TAF5L ENY2 ATXN7L3 USP22 | RNA polymerase II, holoenzyme |
| GO:0003713 | 0.00105381297027 | 0.714285714286 | TADA2B USP22 ENY2 ATXN7L3 TAF5L | transcription coactivator activity |
| GO:0055029 | 0.002536243155 | 0.571428571429 | TAF5L ENY2 ATXN7L3 USP22 | nuclear DNA-directed RNA polymerase complex |
| GO:0000428 | 0.0026497943547 | 0.571428571429 | TAF5L ENY2 ATXN7L3 USP22 | DNA-directed RNA polymerase complex |
| GO:0030880 | 0.00301333997974 | 0.571428571429 | TAF5L ENY2 ATXN7L3 USP22 | RNA polymerase complex |
| GO:0006974 | 0.00462209623318 | 0.857142857143 | TADA2B USP22 ATXN7L3 ENY2 TAF5L SUPT20H | DNA damage response |
| GO:0030674 | 0.00649171551793 | 0.857142857143 | TADA2B USP22 ATXN7L3 ENY2 TAF5L SUPT20H | protein-macromolecule adaptor activity |
| GO:0006259 | 0.00669848388987 | 0.857142857143 | TADA2B USP22 ATXN7L3 ENY2 TAF5L SUPT20H | DNA metabolic process |
| GO:0006396 | 0.00685712478237 | 0.857142857143 | TADA2B USP22 ATXN7L3 ENY2 TAF5L SUPT20H | RNA processing |
| GO:1990234 | 0.0074086488747 | 0.857142857143 | TADA2B USP22 ATXN7L3 ENY2 TAF5L SUPT20H | transferase complex |
| GO:0071819 | 0.00983221512175 | 0.285714285714 | ATXN7L3 ENY2 | DUBm complex |
| GO:0140535 | 0.0104436733939 | 0.857142857143 | TADA2B USP22 ATXN7L3 ENY2 TAF5L SUPT20H | intracellular protein-containing complex |
| GO:0060090 | 0.0165456942242 | 0.857142857143 | TADA2B USP22 ATXN7L3 ENY2 TAF5L SUPT20H | molecular adaptor activity |
| GO:0080134 | 0.0251950754491 | 0.857142857143 | TADA2B USP22 ATXN7L3 ENY2 TAF5L SUPT20H | regulation of response to stress |
| GO:0000785 | 0.0281620326922 | 0.857142857143 | TADA2B USP22 ATXN7L3 ENY2 TAF5L SUPT20H | chromatin |
| GO:0032993 | 0.0399950924513 | 0.857142857143 | TADA2B USP22 ATXN7L3 ENY2 TAF5L SUPT20H | protein-DNA complex |
| GO:0045893 | 0.0448382965284 | 0.857142857143 | TADA2B USP22 ATXN7L3 ENY2 TAF5L SUPT20H | positive regulation of DNA-templated transcription |
| GO:1902680 | 0.0456050287654 | 0.857142857143 | TADA2B USP22 ATXN7L3 ENY2 TAF5L SUPT20H | positive regulation of RNA biosynthetic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| USP22 | ATXN7L3 | 1.0 | 0.126 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TAF5L | SUPT20H | 1.0 | 0.32 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 boldt_WMM WMM_only | |
| ENY2 | ATXN7L3 | 1.0 | 0.154 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TADA2B | SUPT20H | 1.0 | 0.12 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 boldt_WMM | |
| ATXN7L3 | ATXN7L1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| TADA2B | ATXN7L3 | 0.999 | 0.084 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| USP22 | ATXN7L1 | 0.999 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TAF5L | ATXN7L3 | 0.998 | 0.226 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SUPT20H | ATXN7L3 | 0.998 | 0.228 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TAF5L | TADA2B | 0.998 | 0.238 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 boldt_WMM | |
| ENY2 | ATXN7L1 | 0.997 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| TAF5L | ENY2 | 0.989 | 0.144 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM | |
| SUPT20H | ENY2 | 0.978 | 0.152 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| TADA2B | ENY2 | 0.955 | 0.09 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| SUPT20H | ATXN7L1 | 0.95 | bioplex_WMM bioplex3_WMM WMM_only | ||
| TADA2B | ATXN7L1 | 0.948 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SUPT20H | USP22 | 0.942 | 0.11 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| TAF5L | ATXN7L1 | 0.932 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ENY2 | USP22 | 0.908 | 0.052 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| TADA2B | USP22 | 0.803 | 0.1 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| TAF5L | USP22 | 0.632 | 0.088 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes