hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_04293.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| H1-2 | Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1) | 5 | UniProt NCBI |
| H2BC12 | Histone H2B type 1-K (H2B K) (HIRA-interacting protein 1) | 5 | UniProt NCBI |
| RPS10 | Small ribosomal subunit protein eS10 (40S ribosomal protein S10) | 5 | UniProt NCBI |
| FARS2 | Phenylalanine--tRNA ligase, mitochondrial (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase) (PheRS) | 5 | UniProt NCBI |
| RPS20 | Small ribosomal subunit protein uS10 (40S ribosomal protein S20) | 5 | UniProt NCBI |
| BMS1 | Ribosome biogenesis protein BMS1 homolog (Ribosome assembly protein BMS1 homolog) | 5 | UniProt NCBI |
| PURB | Transcriptional regulator protein Pur-beta (Purine-rich element-binding protein B) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-6791226 | 0.00657332630655 | 0.5 | RPS10 BMS1 RPS20 | Major pathway of rRNA processing in the nucleolus and cytosol |
| CORUM:338 | 0.00690345882544 | 0.333333333333 | RPS10 RPS20 | 40S ribosomal subunit, cytoplasmic |
| REAC:R-HSA-8868773 | 0.00772571498835 | 0.5 | RPS10 BMS1 RPS20 | rRNA processing in the nucleus and cytosol |
| CORUM:305 | 0.00790378311242 | 0.333333333333 | RPS10 RPS20 | 40S ribosomal subunit, cytoplasmic |
| REAC:R-HSA-72312 | 0.00900407624294 | 0.5 | RPS10 BMS1 RPS20 | rRNA processing |
| REAC:R-HSA-9735869 | 0.0170865043842 | 0.333333333333 | RPS10 RPS20 | SARS-CoV-1 modulates host translation machinery |
| REAC:R-HSA-72766 | 0.0266429590673 | 0.5 | RPS10 FARS2 RPS20 | Translation |
| REAC:R-HSA-9754678 | 0.0326270815028 | 0.333333333333 | RPS10 RPS20 | SARS-CoV-2 modulates host translation machinery |
| REAC:R-HSA-72695 | 0.0339259639772 | 0.333333333333 | RPS10 RPS20 | Formation of the ternary complex, and subsequently, the 43S complex |
| HP:0031640 | 0.0349615340576 | 0.333333333333 | RPS10 RPS20 | Abnormal radial artery morphology |
| HP:0030270 | 0.0349615340576 | 0.333333333333 | RPS10 RPS20 | Elevated red cell adenosine deaminase activity |
| HP:0020118 | 0.0349615340576 | 0.333333333333 | RPS10 RPS20 | Radial artery aplasia |
| WP:WP477 | 0.0371136030036 | 0.333333333333 | RPS10 RPS20 | Cytoplasmic ribosomal proteins |
| HP:4000209 | 0.037751561683 | 0.333333333333 | RPS10 RPS20 | Abnormal erythrocyte adenosine deaminase activity |
| HP:0005532 | 0.0406481036194 | 0.333333333333 | RPS10 RPS20 | Macrocytic dyserythropoietic anemia |
| HP:0012410 | 0.0406481036194 | 0.333333333333 | RPS10 RPS20 | Pure red cell aplasia |
| REAC:R-HSA-72649 | 0.0437202891307 | 0.333333333333 | RPS10 RPS20 | Translation initiation complex formation |
| REAC:R-HSA-72702 | 0.0437202891307 | 0.333333333333 | RPS10 RPS20 | Ribosomal scanning and start codon recognition |
| CORUM:306 | 0.0443275587237 | 0.333333333333 | RPS10 RPS20 | Ribosome, cytoplasmic |
| REAC:R-HSA-72662 | 0.0452196184553 | 0.333333333333 | RPS10 RPS20 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| HP:0012133 | 0.0499762286031 | 0.333333333333 | RPS10 RPS20 | Erythroid hypoplasia |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RPS10 | RPS20 | 0.997 | 0.998 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| PURB | RPS10 | 0.997 | 0.128 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction treiber_WMM |
| H2BC12 | RPS10 | 0.991 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM treiber_WMM WMM_only | |
| H1-2 | RPS10 | 0.986 | 0.168 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM WMM_only |
| RPS10 | FARS2 | 0.979 | 0.158 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| BMS1 | RPS10 | 0.977 | 0.458 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 treiber_WMM WMM_only |
| BMS1 | PURB | 0.835 | 0.042 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only treiber_WMM |
| PURB | FARS2 | 0.831 | 0.034 | bioplex_WMM bioplex3_WMM WMM_only |
| FARS2 | RPS20 | 0.813 | 0.244 | bioplex_WMM bioplex3_WMM WMM_only |
| BMS1 | H1-2 | 0.753 | 0.3 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM treiber_WMM WMM_only |
| PURB | H1-2 | 0.752 | 0.168 | bioplex3_HEK293 bioplex3_WMM youn_WMM gupta_WMM treiber_WMM WMM_only |
| PURB | RPS20 | 0.734 | 0.118 | bioplex_WMM bioplex3_WMM gupta_WMM fraction treiber_WMM |
| BMS1 | FARS2 | 0.669 | 0.062 | bioplex_WMM bioplex3_WMM WMM_only |
| H1-2 | FARS2 | 0.562 | 0.26 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| BMS1 | RPS20 | 0.326 | 0.69 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only treiber_WMM |
| PURB | H2BC12 | 0.235 | bioplex_WMM bioplex3_WMM WMM_only | |
| H1-2 | RPS20 | 0.212 | 0.19 | hein_WMM bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM treiber_WMM WMM_only |
| H1-2 | H2BC12 | 0.183 | bioplex_WMM bioplex3_WMM WMM_only treiber_WMM | |
| BMS1 | H2BC12 | 0.136 | bioplex_WMM bioplex3_WMM WMM_only treiber_WMM | |
| H2BC12 | FARS2 | 0.11 | bioplex_WMM bioplex3_WMM WMM_only | |
| H2BC12 | RPS20 | 0.03 | bioplex_WMM bioplex3_WMM boldt boldt_WMM treiber_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| H1-2 | huMAP3_04293.1 huMAP3_15331.1 |
| H2BC12 | huMAP3_04293.1 |
| RPS10 | huMAP3_04293.1 |
| FARS2 | huMAP3_04293.1 |
| RPS20 | huMAP3_04293.1 huMAP3_11724.1 |
| BMS1 | huMAP3_00778.1 huMAP3_04293.1 |
| PURB | huMAP3_02503.1 huMAP3_04293.1 huMAP3_10045.1 huMAP3_14083.1 |