hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04301.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PLCD3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-3) (Phospholipase C-delta-3) (PLC-delta-3) | 5 | UniProt NCBI |
| PIP4K2C | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC 2.7.1.149) (Phosphatidylinositol 5-phosphate 4-kinase type II gamma) (PI(5)P 4-kinase type II gamma) (PIP4KII-gamma) | 5 | UniProt NCBI |
| PIP4K2B | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-beta) (PtdIns(5)P-4-kinase isoform 2-beta) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP5411 | 8.89885541579e-07 | 1.0 | PLCD3 PIP4K2C PIP4K2B | Phosphatidyl inositol phosphate pathway |
| WP:WP4971 | 8.89885541579e-07 | 1.0 | PLCD3 PIP4K2C PIP4K2B | Phosphoinositides metabolism |
| KEGG:00562 | 2.28180619251e-06 | 1.0 | PLCD3 PIP4K2C PIP4K2B | Inositol phosphate metabolism |
| KEGG:04070 | 5.159661118e-06 | 1.0 | PLCD3 PIP4K2C PIP4K2B | Phosphatidylinositol signaling system |
| REAC:R-HSA-8847453 | 4.09070097144e-05 | 0.666666666667 | PIP4K2B PIP4K2C | Synthesis of PIPs in the nucleus |
| REAC:R-HSA-6811555 | 0.00024538606603 | 0.666666666667 | PIP4K2B PIP4K2C | PI5P Regulates TP53 Acetylation |
| REAC:R-HSA-6804758 | 0.00296224002415 | 0.666666666667 | PIP4K2B PIP4K2C | Regulation of TP53 Activity through Acetylation |
| GO:0016309 | 0.00421361424067 | 0.666666666667 | PIP4K2B PIP4K2C | 1-phosphatidylinositol-5-phosphate 4-kinase activity |
| GO:1902633 | 0.00421361424067 | 0.666666666667 | PIP4K2B PIP4K2C | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process |
| GO:1902635 | 0.00421361424067 | 0.666666666667 | PIP4K2B PIP4K2C | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process |
| REAC:R-HSA-1660499 | 0.00735562020533 | 0.666666666667 | PIP4K2B PIP4K2C | Synthesis of PIPs at the plasma membrane |
| WP:WP51 | 0.00915401629696 | 0.666666666667 | PIP4K2B PIP4K2C | Regulation of actin cytoskeleton |
| KEGG:04810 | 0.01431202154 | 0.666666666667 | PIP4K2B PIP4K2C | Regulation of actin cytoskeleton |
| REAC:R-HSA-1483255 | 0.017372320015 | 0.666666666667 | PIP4K2B PIP4K2C | PI Metabolism |
| REAC:R-HSA-6811558 | 0.0183561585619 | 0.666666666667 | PIP4K2B PIP4K2C | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| KEGG:01100 | 0.0189521995452 | 1.0 | PLCD3 PIP4K2C PIP4K2B | Metabolic pathways |
| REAC:R-HSA-199418 | 0.0220121799777 | 0.666666666667 | PIP4K2B PIP4K2C | Negative regulation of the PI3K/AKT network |
| GO:0016308 | 0.0393180950424 | 0.666666666667 | PIP4K2B PIP4K2C | 1-phosphatidylinositol-4-phosphate 5-kinase activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PIP4K2B | PIP4K2C | 1.0 | 0.014 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM |
| PLCD3 | PIP4K2C | 0.994 | 0.15 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| PIP4K2B | PLCD3 | 0.95 | 0.068 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes