hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04302.1
Complex Portal: CPX-23517
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| STK40 | Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase) (Sugen kinase 495) (SgK495) | 5 | UniProt NCBI |
| ETV5 | ETS translocation variant 5 (Ets-related protein ERM) | 5 | UniProt NCBI |
| FOSB | Protein FosB (FosB proto-oncogene, AP-1 transcription factor subunit) (G0/G1 switch regulatory protein 3) (Transcription factor AP-1 subunit FosB) | 5 | UniProt NCBI |
| DET1 | DET1 homolog (De-etiolated-1 homolog) | 5 | UniProt NCBI |
| ETV1 | ETS translocation variant 1 (Ets-related protein 81) | 5 | UniProt NCBI |
| FOS | Protein c-Fos (Cellular oncogene fos) (Fos proto-oncogene, AP-1 transcription factor subunit) (G0/G1 switch regulatory protein 7) (Proto-oncogene c-Fos) (Transcription factor AP-1 subunit c-Fos) | 5 | UniProt NCBI |
| TRIB2 | Tribbles homolog 2 (TRB-2) | 5 | UniProt NCBI |
| COP1 | E3 ubiquitin-protein ligase COP1 (EC 2.3.2.27) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1) (RING finger and WD repeat domain protein 2) (RING finger protein 200) (RING-type E3 ubiquitin transferase RFWD2) | 5 | UniProt NCBI |
| TRIB1 | Tribbles homolog 1 (TRB-1) (G-protein-coupled receptor-induced gene 2 protein) (GIG-2) (SKIP1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9031628 | 0.000188109751173 | 0.333333333333 | FOSB FOS TRIB1 | NGF-stimulated transcription |
| CORUM:1214 | 0.000273361732609 | 0.222222222222 | COP1 DET1 | Ubiquitin E3 ligase (DET1, DDB1, CUL4A, RBX1, COP1) |
| REAC:R-HSA-198725 | 0.000934338987799 | 0.333333333333 | FOSB FOS TRIB1 | Nuclear Events (kinase and transcription factor activation) |
| GO:0032436 | 0.00298534559142 | 0.444444444444 | COP1 TRIB1 DET1 TRIB2 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| REAC:R-HSA-187037 | 0.00548064743149 | 0.333333333333 | FOSB FOS TRIB1 | Signaling by NTRK1 (TRKA) |
| GO:2000060 | 0.00625820430729 | 0.444444444444 | COP1 TRIB1 DET1 TRIB2 | positive regulation of ubiquitin-dependent protein catabolic process |
| GO:1901800 | 0.00827392856677 | 0.444444444444 | COP1 TRIB1 DET1 TRIB2 | positive regulation of proteasomal protein catabolic process |
| REAC:R-HSA-166520 | 0.00889169623462 | 0.333333333333 | FOSB FOS TRIB1 | Signaling by NTRKs |
| GO:1903052 | 0.0154150912184 | 0.444444444444 | COP1 TRIB1 DET1 TRIB2 | positive regulation of proteolysis involved in protein catabolic process |
| GO:0032434 | 0.0172675356747 | 0.444444444444 | COP1 TRIB1 DET1 TRIB2 | regulation of proteasomal ubiquitin-dependent protein catabolic process |
| WP:WP2849 | 0.0191680266266 | 0.222222222222 | FOSB FOS | Hematopoietic stem cell differentiation |
| WP:WP5373 | 0.0225236492456 | 0.222222222222 | FOSB FOS | Role of hypoxia angiogenesis and FGF pathway in OA chondrocyte hypertrophy |
| KEGG:05031 | 0.0267263448961 | 0.222222222222 | FOSB FOS | Amphetamine addiction |
| GO:2000058 | 0.041079120868 | 0.444444444444 | COP1 TRIB1 DET1 TRIB2 | regulation of ubiquitin-dependent protein catabolic process |
| KEGG:04657 | 0.0486860700236 | 0.222222222222 | FOSB FOS | IL-17 signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| COP1 | TRIB1 | 1.0 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| DET1 | TRIB1 | 1.0 |
structurally_consistent (Q92519)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| STK40 | DET1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| DET1 | COP1 | 0.999 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ETV5 | COP1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| ETV1 | COP1 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| STK40 | TRIB1 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| TRIB2 | TRIB1 | 0.998 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| DET1 | TRIB2 | 0.998 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TRIB2 | COP1 | 0.998 |
structurally_consistent (Q96RU8)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| STK40 | TRIB2 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| STK40 | ETV5 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ETV5 | DET1 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| STK40 | ETV1 | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| TRIB1 | FOS | 0.992 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| STK40 | COP1 | 0.991 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| STK40 | FOS | 0.991 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| COP1 | FOS | 0.99 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | ||
| DET1 | ETV1 | 0.988 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| DET1 | FOS | 0.975 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| FOSB | TRIB1 | 0.96 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| FOSB | COP1 | 0.954 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| FOSB | STK40 | 0.943 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ETV5 | ETV1 | 0.902 | bioplex3_WMM WMM_only | ||
| ETV5 | TRIB1 | 0.418 | bioplex3_WMM WMM_only | ||
| ETV1 | TRIB1 | 0.418 | bioplex3_WMM WMM_only | ||
| FOSB | DET1 | 0.172 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes