hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04305.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| INCENP | Inner centromere protein | 5 | UniProt NCBI |
| CDCA8 | Borealin (Cell division cycle-associated protein 8) (Dasra-B) (hDasra-B) (Pluripotent embryonic stem cell-related gene 3 protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1120 | 5.12628525639e-06 | 1.0 | INCENP CDCA8 | Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5) |
| CORUM:1118 | 1.02525705128e-05 | 1.0 | INCENP CDCA8 | Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5, AURKB) |
| CORUM:1119 | 1.02525705128e-05 | 1.0 | INCENP CDCA8 | Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5, AURKB) |
| REAC:R-HSA-4615885 | 0.00147124386858 | 1.0 | INCENP CDCA8 | SUMOylation of DNA replication proteins |
| GO:0032133 | 0.00702301080125 | 1.0 | INCENP CDCA8 | chromosome passenger complex |
| REAC:R-HSA-141424 | 0.00715287669441 | 1.0 | INCENP CDCA8 | Amplification of signal from the kinetochores |
| REAC:R-HSA-141444 | 0.00715287669441 | 1.0 | INCENP CDCA8 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| GO:1903490 | 0.00983221512175 | 1.0 | INCENP CDCA8 | positive regulation of mitotic cytokinesis |
| REAC:R-HSA-69618 | 0.0098732254038 | 1.0 | INCENP CDCA8 | Mitotic Spindle Checkpoint |
| REAC:R-HSA-9648025 | 0.0108130443675 | 1.0 | INCENP CDCA8 | EML4 and NUDC in mitotic spindle formation |
| HPA:0030432 | 0.0115004058622 | 1.0 | INCENP CDCA8 | appendix; germinal center cells[>=Medium] |
| HPA:0031293 | 0.0116183587428 | 1.0 | INCENP CDCA8 | appendix; endocrine cells[High] |
| REAC:R-HSA-2500257 | 0.0124056103205 | 1.0 | INCENP CDCA8 | Resolution of Sister Chromatid Cohesion |
| GO:1902412 | 0.0131096201623 | 1.0 | INCENP CDCA8 | regulation of mitotic cytokinesis |
| GO:1902423 | 0.0131096201623 | 1.0 | INCENP CDCA8 | regulation of attachment of mitotic spindle microtubules to kinetochore |
| GO:1902425 | 0.0131096201623 | 1.0 | INCENP CDCA8 | positive regulation of attachment of mitotic spindle microtubules to kinetochore |
| HPA:0131293 | 0.014103794442 | 1.0 | INCENP CDCA8 | colon; endocrine cells[High] |
| REAC:R-HSA-5663220 | 0.0147739541089 | 1.0 | INCENP CDCA8 | RHO GTPases Activate Formins |
| HPA:0401293 | 0.0161258438244 | 1.0 | INCENP CDCA8 | rectum; endocrine cells[High] |
| HPA:0030431 | 0.0184319430009 | 1.0 | INCENP CDCA8 | appendix; germinal center cells[>=Low] |
| HPA:0151293 | 0.0201067535459 | 1.0 | INCENP CDCA8 | duodenum; endocrine cells[High] |
| REAC:R-HSA-3108232 | 0.0211937720117 | 1.0 | INCENP CDCA8 | SUMO E3 ligases SUMOylate target proteins |
| REAC:R-HSA-2990846 | 0.0225607814134 | 1.0 | INCENP CDCA8 | SUMOylation |
| HPA:0030441 | 0.0253929683598 | 1.0 | INCENP CDCA8 | appendix; non-germinal center cells[>=Low] |
| GO:0051256 | 0.0257510396046 | 1.0 | INCENP CDCA8 | mitotic spindle midzone assembly |
| GO:0051987 | 0.0257510396046 | 1.0 | INCENP CDCA8 | positive regulation of attachment of spindle microtubules to kinetochore |
| REAC:R-HSA-2467813 | 0.0287687128588 | 1.0 | INCENP CDCA8 | Separation of Sister Chromatids |
| HPA:0031292 | 0.0293847104887 | 1.0 | INCENP CDCA8 | appendix; endocrine cells[>=Medium] |
| HPA:0030891 | 0.0305239186675 | 1.0 | INCENP CDCA8 | appendix; goblet cells[>=Low] |
| GO:0000022 | 0.0309012475255 | 1.0 | INCENP CDCA8 | mitotic spindle elongation |
| GO:0090267 | 0.0309012475255 | 1.0 | INCENP CDCA8 | positive regulation of mitotic cell cycle spindle assembly checkpoint |
| GO:0090235 | 0.0309012475255 | 1.0 | INCENP CDCA8 | regulation of metaphase plate congression |
| GO:0051255 | 0.0309012475255 | 1.0 | INCENP CDCA8 | spindle midzone assembly |
| REAC:R-HSA-68877 | 0.0323212285415 | 1.0 | INCENP CDCA8 | Mitotic Prometaphase |
| HPA:0401332 | 0.0336677240168 | 1.0 | INCENP CDCA8 | rectum; mucosal lymphoid cells[>=Medium] |
| HPA:0150891 | 0.0342743388315 | 1.0 | INCENP CDCA8 | duodenum; goblet cells[>=Low] |
| HPA:0401292 | 0.03468175771 | 1.0 | INCENP CDCA8 | rectum; endocrine cells[>=Medium] |
| HPA:0400891 | 0.0348863698499 | 1.0 | INCENP CDCA8 | rectum; goblet cells[>=Low] |
| HPA:0131292 | 0.035503817072 | 1.0 | INCENP CDCA8 | colon; endocrine cells[>=Medium] |
| GO:0051231 | 0.0365196561665 | 1.0 | INCENP CDCA8 | spindle elongation |
| GO:0090232 | 0.0365196561665 | 1.0 | INCENP CDCA8 | positive regulation of spindle checkpoint |
| HPA:0031291 | 0.0367549601274 | 1.0 | INCENP CDCA8 | appendix; endocrine cells[>=Low] |
| HPA:0131291 | 0.0419761804968 | 1.0 | INCENP CDCA8 | colon; endocrine cells[>=Low] |
| HPA:0401291 | 0.0419761804968 | 1.0 | INCENP CDCA8 | rectum; endocrine cells[>=Low] |
| REAC:R-HSA-68882 | 0.0422969796504 | 1.0 | INCENP CDCA8 | Mitotic Anaphase |
| REAC:R-HSA-2555396 | 0.0426780335212 | 1.0 | INCENP CDCA8 | Mitotic Metaphase and Anaphase |
| HPA:0381192 | 0.0433356476262 | 1.0 | INCENP CDCA8 | placenta; cytotrophoblasts[>=Medium] |
| HPA:0151292 | 0.0440235054965 | 1.0 | INCENP CDCA8 | duodenum; endocrine cells[>=Medium] |
| HPA:0031301 | 0.0485057149607 | 1.0 | INCENP CDCA8 | appendix; enterocytes[>=Low] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CDCA8 | INCENP | 0.998 | 0.606 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () |
Related Complexes