hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04307.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SIRPG | Signal-regulatory protein gamma (SIRP-gamma) (CD172 antigen-like family member B) (Signal-regulatory protein beta-2) (SIRP-b2) (SIRP-beta-2) (CD antigen CD172g) | 5 | UniProt NCBI |
| SIRPA | Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (Macrophage fusion receptor) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (Signal-regulatory protein alpha-2) (Sirp-alpha-2) (Signal-regulatory protein alpha-3) (Sirp-alpha-3) (p84) (CD antigen CD172a) | 5 | UniProt NCBI |
| SH2D1B | SH2 domain-containing protein 1B (EWS/FLI1-activated transcript 2) (EAT-2) | 5 | UniProt NCBI |
| SIRPB1 | Signal-regulatory protein beta-1 isoform 3 (SIRP-beta-1 isoform 3) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-391160 | 2.31434954766e-07 | 0.75 | SIRPA SIRPG SIRPB1 | Signal regulatory protein family interactions |
| KEGG:04380 | 8.42717414951e-05 | 0.75 | SIRPA SIRPG SIRPB1 | Osteoclast differentiation |
| KEGG:04148 | 0.000105799991328 | 0.75 | SIRPA SIRPG SIRPB1 | Efferocytosis |
| REAC:R-HSA-1500931 | 0.000246885749652 | 0.75 | SIRPA SIRPG SIRPB1 | Cell-Cell communication |
| GO:0050766 | 0.00847564117007 | 0.75 | SIRPA SIRPG SIRPB1 | positive regulation of phagocytosis |
| WP:WP4673 | 0.017442995787 | 0.5 | SIRPA SIRPG | Male infertility |
| GO:0050764 | 0.0218982649712 | 0.75 | SIRPA SIRPG SIRPB1 | regulation of phagocytosis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SIRPG | SIRPA | 0.991 | 0.166 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| SIRPA | SIRPB1 | 0.99 | 0.382 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| SIRPA | SH2D1B | 0.981 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes