hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04314.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| STAT1 | Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84) | 5 | UniProt NCBI |
| STAT2 | Signal transducer and activator of transcription 2 (p113) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:60 | 5.12628525639e-06 | 1.0 | STAT1 STAT2 | Interferon-stimulated gene factor 3 transcription complex ISGF3 |
| WP:WP2113 | 1.91536658216e-05 | 1.0 | STAT1 STAT2 | Type III interferon signaling |
| WP:WP4495 | 1.91536658216e-05 | 1.0 | STAT1 STAT2 | IL 10 anti inflammatory signaling pathway |
| WP:WP4197 | 8.08710334689e-05 | 1.0 | STAT1 STAT2 | Immune response to tuberculosis |
| WP:WP4868 | 0.000107686165619 | 1.0 | STAT1 STAT2 | Type I interferon induction and signaling during SARS CoV 2 infection |
| WP:WP619 | 0.000149398593408 | 1.0 | STAT1 STAT2 | Type II interferon signaling |
| WP:WP4880 | 0.000172808629413 | 1.0 | STAT1 STAT2 | Host pathogen interaction of human coronaviruses interferon induction |
| WP:WP4912 | 0.000185152102942 | 1.0 | STAT1 STAT2 | SARS coronavirus and innate immunity |
| WP:WP4558 | 0.000253254025863 | 1.0 | STAT1 STAT2 | Overview of interferons mediated signaling pathway |
| REAC:R-HSA-8854691 | 0.000394723964742 | 1.0 | STAT1 STAT2 | Interleukin-20 family signaling |
| HP:0020085 | 0.000410102820511 | 1.0 | STAT1 STAT2 | Infection following live vaccination |
| WP:WP585 | 0.000542687198278 | 1.0 | STAT1 STAT2 | Interferon type I signaling pathways |
| WP:WP5039 | 0.00056439468621 | 1.0 | STAT1 STAT2 | SARS CoV 2 innate immunity evasion and cell specific immune response |
| KEGG:04625 | 0.00058037380927 | 1.0 | STAT1 STAT2 | C-type lectin receptor signaling pathway |
| KEGG:04620 | 0.000608173227025 | 1.0 | STAT1 STAT2 | Toll-like receptor signaling pathway |
| WP:WP4341 | 0.000831269096657 | 1.0 | STAT1 STAT2 | Non genomic actions of 1 25 dihydroxyvitamin D3 |
| KEGG:04380 | 0.00106564434727 | 1.0 | STAT1 STAT2 | Osteoclast differentiation |
| KEGG:05162 | 0.00123975649005 | 1.0 | STAT1 STAT2 | Measles |
| KEGG:04630 | 0.00138428094844 | 1.0 | STAT1 STAT2 | JAK-STAT signaling pathway |
| KEGG:05160 | 0.00138428094844 | 1.0 | STAT1 STAT2 | Hepatitis C |
| GO:0070721 | 0.00140460216025 | 1.0 | STAT1 STAT2 | ISGF3 complex |
| KEGG:04217 | 0.00151449927371 | 1.0 | STAT1 STAT2 | Necroptosis |
| KEGG:04062 | 0.00155920593969 | 1.0 | STAT1 STAT2 | Chemokine signaling pathway |
| KEGG:05164 | 0.0016738175743 | 1.0 | STAT1 STAT2 | Influenza A |
| KEGG:04621 | 0.001720800216 | 1.0 | STAT1 STAT2 | NOD-like receptor signaling pathway |
| KEGG:05161 | 0.00176843313648 | 1.0 | STAT1 STAT2 | Hepatitis B |
| KEGG:05167 | 0.00228052767407 | 1.0 | STAT1 STAT2 | Kaposi sarcoma-associated herpesvirus infection |
| WP:WP236 | 0.00241378753054 | 1.0 | STAT1 STAT2 | Adipogenesis |
| KEGG:05169 | 0.00261899777797 | 1.0 | STAT1 STAT2 | Epstein-Barr virus infection |
| WP:WP3929 | 0.00309012475255 | 1.0 | STAT1 STAT2 | Chemokine signaling pathway |
| REAC:R-HSA-909733 | 0.0031270340064 | 1.0 | STAT1 STAT2 | Interferon alpha/beta signaling |
| WP:WP4630 | 0.00319355454799 | 1.0 | STAT1 STAT2 | Measles virus infection |
| KEGG:05171 | 0.0033003273675 | 1.0 | STAT1 STAT2 | Coronavirus disease - COVID-19 |
| WP:WP4666 | 0.00396523446209 | 1.0 | STAT1 STAT2 | Hepatitis B infection |
| HP:0032169 | 0.00526298619656 | 1.0 | STAT1 STAT2 | Severe infection |
| KEGG:05165 | 0.00700203931066 | 1.0 | STAT1 STAT2 | Human papillomavirus infection |
| REAC:R-HSA-9705671 | 0.0106216630512 | 1.0 | STAT1 STAT2 | SARS-CoV-2 activates/modulates innate and adaptive immune responses |
| KEGG:05168 | 0.0109183432505 | 1.0 | STAT1 STAT2 | Herpes simplex virus 1 infection |
| KEGG:05200 | 0.0161326036311 | 1.0 | STAT1 STAT2 | Pathways in cancer |
| REAC:R-HSA-913531 | 0.0260158976762 | 1.0 | STAT1 STAT2 | Interferon Signaling |
| REAC:R-HSA-9705683 | 0.0300366140789 | 1.0 | STAT1 STAT2 | SARS-CoV-2-host interactions |
| HP:0001888 | 0.0376816141579 | 1.0 | STAT1 STAT2 | Lymphopenia |
| CORUM:5573 | 0.0499419797295 | 0.5 | STAT1 | Stat1-alpha-dimer-CBP DNA-protein complex |
| HP:0033608 | 0.0499436884913 | 0.5 | STAT1 | Pulmonary nodule |
| HP:0032257 | 0.0499436884913 | 0.5 | STAT1 | Disseminated histoplasmosis |
| HP:0012204 | 0.0499436884913 | 0.5 | STAT1 | Recurrent vulvovaginal candidiasis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| STAT1 | STAT2 | 1.0 | 0.272 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| STAT1 | huMAP3_04314.1 |
| STAT2 | huMAP3_04314.1 huMAP3_14273.1 |